BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

262 related articles for article (PubMed ID: 11948243)

  • 1. Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.
    Bodendorf U; Danner S; Fischer F; Stefani M; Sturchler-Pierrat C; Wiederhold KH; Staufenbiel M; Paganetti P
    J Neurochem; 2002 Mar; 80(5):799-806. PubMed ID: 11948243
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity.
    Fischer F; Molinari M; Bodendorf U; Paganetti P
    J Neurochem; 2002 Mar; 80(6):1079-88. PubMed ID: 11953458
    [TBL] [Abstract][Full Text] [Related]  

  • 4. BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
    Zhang S; Wang Z; Cai F; Zhang M; Wu Y; Zhang J; Song W
    J Neurosci; 2017 Jul; 37(29):6915-6925. PubMed ID: 28626014
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.
    Liu K; Doms RW; Lee VM
    Biochemistry; 2002 Mar; 41(9):3128-36. PubMed ID: 11863452
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology.
    Mohajeri MH; Saini KD; Nitsch RM
    J Neural Transm (Vienna); 2004 Mar; 111(3):413-25. PubMed ID: 14991462
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D; Kienlen-Campard P; Octave JN
    J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
    Chiocco MJ; Kulnane LS; Younkin L; Younkin S; Evin G; Lamb BT
    J Biol Chem; 2004 Dec; 279(50):52535-42. PubMed ID: 15452128
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
    Vassar R; Bennett BD; Babu-Khan S; Kahn S; Mendiaz EA; Denis P; Teplow DB; Ross S; Amarante P; Loeloff R; Luo Y; Fisher S; Fuller J; Edenson S; Lile J; Jarosinski MA; Biere AL; Curran E; Burgess T; Louis JC; Collins F; Treanor J; Rogers G; Citron M
    Science; 1999 Oct; 286(5440):735-41. PubMed ID: 10531052
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Degradation of BACE by the ubiquitin-proteasome pathway.
    Qing H; Zhou W; Christensen MA; Sun X; Tong Y; Song W
    FASEB J; 2004 Oct; 18(13):1571-3. PubMed ID: 15289451
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
    Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
    [TBL] [Abstract][Full Text] [Related]  

  • 14. MicroRNA-384 regulates both amyloid precursor protein and β-secretase expression and is a potential biomarker for Alzheimer's disease.
    Liu CG; Wang JL; Li L; Wang PC
    Int J Mol Med; 2014 Jul; 34(1):160-6. PubMed ID: 24827165
    [TBL] [Abstract][Full Text] [Related]  

  • 15. beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging.
    Irizarry MC; Locascio JJ; Hyman BT
    Am J Pathol; 2001 Jan; 158(1):173-7. PubMed ID: 11141490
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages.
    Devi L; Ohno M
    Neuroscience; 2015 Oct; 307():128-37. PubMed ID: 26314636
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fenofibrate reduces amyloidogenic processing of APP in APP/PS1 transgenic mice via PPAR-α/PI3-K pathway.
    Zhang H; Gao Y; Qiao PF; Zhao FL; Yan Y
    Int J Dev Neurosci; 2014 Nov; 38():223-31. PubMed ID: 25447788
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein.
    Cordy JM; Hussain I; Dingwall C; Hooper NM; Turner AJ
    Proc Natl Acad Sci U S A; 2003 Sep; 100(20):11735-40. PubMed ID: 14504402
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PPAR-α agonist regulates amyloid-β generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene.
    Zhang H; Gao Y; Qiao PF; Zhao FL; Yan Y
    Mol Cell Biochem; 2015 Oct; 408(1-2):37-46. PubMed ID: 26092426
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
    Gandhi S; Refolo LM; Sambamurti K
    J Mol Neurosci; 2004; 24(1):137-43. PubMed ID: 15314262
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.