These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 11956193)

  • 21. An aggrecanase and osteoarthritis.
    Karsenty G
    N Engl J Med; 2005 Aug; 353(5):522-3. PubMed ID: 16079379
    [No Abstract]   [Full Text] [Related]  

  • 22. Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
    Chockalingam PS; Zeng W; Morris EA; Flannery CR
    Arthritis Rheum; 2004 Sep; 50(9):2839-48. PubMed ID: 15457452
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression.
    Pattoli MA; MacMaster JF; Gregor KR; Burke JR
    J Pharmacol Exp Ther; 2005 Oct; 315(1):382-8. PubMed ID: 16009742
    [TBL] [Abstract][Full Text] [Related]  

  • 24. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
    Kashiwagi M; Tortorella M; Nagase H; Brew K
    J Biol Chem; 2001 Apr; 276(16):12501-4. PubMed ID: 11278243
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
    Stanton H; Ung L; Fosang AJ
    Biochem J; 2002 May; 364(Pt 1):181-90. PubMed ID: 11988091
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
    Clements KM; Price JS; Chambers MG; Visco DM; Poole AR; Mason RM
    Arthritis Rheum; 2003 Dec; 48(12):3452-63. PubMed ID: 14673996
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo.
    Madsen SH; Sumer EU; Bay-Jensen AC; Sondergaard BC; Qvist P; Karsdal MA
    Biomarkers; 2010 May; 15(3):266-76. PubMed ID: 20039789
    [TBL] [Abstract][Full Text] [Related]  

  • 28. MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.
    Struglics A; Hansson M
    Biochem J; 2012 Sep; 446(2):213-23. PubMed ID: 22670872
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.
    Song RH; Tortorella MD; Malfait AM; Alston JT; Yang Z; Arner EC; Griggs DW
    Arthritis Rheum; 2007 Feb; 56(2):575-85. PubMed ID: 17265492
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.
    Moulharat N; Lesur C; Thomas M; Rolland-Valognes G; Pastoureau P; Anract P; De Ceuninck F; Sabatini M
    Osteoarthritis Cartilage; 2004 Apr; 12(4):296-305. PubMed ID: 15023381
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis.
    Hughes CE; Little CB; Caterson B
    Methods Mol Biol; 2003; 225():89-98. PubMed ID: 12769477
    [No Abstract]   [Full Text] [Related]  

  • 32. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
    Tortorella MD; Burn TC; Pratta MA; Abbaszade I; Hollis JM; Liu R; Rosenfeld SA; Copeland RA; Decicco CP; Wynn R; Rockwell A; Yang F; Duke JL; Solomon K; George H; Bruckner R; Nagase H; Itoh Y; Ellis DM; Ross H; Wiswall BH; Murphy K; Hillman MC; Hollis GF; Newton RC; Magolda RL; Trzaskos JM; Arner EC
    Science; 1999 Jun; 284(5420):1664-6. PubMed ID: 10356395
    [TBL] [Abstract][Full Text] [Related]  

  • 33. ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.
    Verma P; Dalal K
    J Cell Biochem; 2011 Dec; 112(12):3507-14. PubMed ID: 21815191
    [TBL] [Abstract][Full Text] [Related]  

  • 34. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD; Pratta MA; Fox JW; Arner EC
    J Biol Chem; 1998 Mar; 273(10):5846-50. PubMed ID: 9488721
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Aggrecanases in the human synovial fluid at different stages of osteoarthritis.
    Zhang E; Yan X; Zhang M; Chang X; Bai Z; He Y; Yuan Z
    Clin Rheumatol; 2013 Jun; 32(6):797-803. PubMed ID: 23370724
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.
    Troeberg L; Fushimi K; Khokha R; Emonard H; Ghosh P; Nagase H
    FASEB J; 2008 Oct; 22(10):3515-24. PubMed ID: 18632849
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
    Sandy JD; Verscharen C
    Biochem J; 2001 Sep; 358(Pt 3):615-26. PubMed ID: 11535123
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Proprotein convertase activation of aggrecanases in cartilage in situ.
    Malfait AM; Arner EC; Song RH; Alston JT; Markosyan S; Staten N; Yang Z; Griggs DW; Tortorella MD
    Arch Biochem Biophys; 2008 Oct; 478(1):43-51. PubMed ID: 18671934
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice.
    Chambers MG; Cox L; Chong L; Suri N; Cover P; Bayliss MT; Mason RM
    Arthritis Rheum; 2001 Jun; 44(6):1455-65. PubMed ID: 11407708
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
    De Savi C; Pape A; Sawyer Y; Milne D; Davies C; Cumming JG; Ting A; Lamont S; Smith PD; Tart J; Page K; Moore P
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3301-6. PubMed ID: 21536437
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 15.