These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 11960494)

  • 1. Rational design, synthesis, and biological activity of novel conformationally restricted vitamin D analogues, (22R)- and (22S)-22-ethyl-1,25-dihydroxy-23,24-didehydro-24a,24b-dihomo-20-epivitamin D(3).
    Masuno H; Yamamoto K; Wang X; Choi M; Ooizumi H; Shinki T; Yamada S
    J Med Chem; 2002 Apr; 45(9):1825-34. PubMed ID: 11960494
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs.
    Takayama H; Kittaka A; Fujishima T; Suhara Y
    Recent Results Cancer Res; 2003; 164():289-317. PubMed ID: 12899530
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological activity of 22-iodo- and (E)-20(22)-dehydro analogues of 1alpha,25-dihydroxyvitamin D3.
    Sicinski RR; DeLuca HF
    Bioorg Med Chem; 1999 Dec; 7(12):2877-89. PubMed ID: 10658592
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of 25-hydroxyl group orientation on biological activity and binding to the 1alpha,25-dihydroxy vitamin D3 receptor.
    Collins ED; Bishop JE; Bula CM; Acevedo A; Okamura WH; Norman AW
    J Steroid Biochem Mol Biol; 2005 Mar; 94(4):279-88. PubMed ID: 15857747
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D(3): transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells.
    Nakagawa K; Kurobe M; Ozono K; Konno K; Fujishima T; Takayama H; Okano T
    Biochem Pharmacol; 2000 Mar; 59(6):691-702. PubMed ID: 10677586
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, biological evaluation, and conformational analysis of A-ring diastereomers of 2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: unique activity profiles depending on the stereochemistry of the A-ring and at C-20.
    Konno K; Fujishima T; Maki S; Liu Z; Miura D; Chokki M; Ishizuka S; Yamaguchi K; Kan Y; Kurihara M; Miyata N; Smith C; DeLuca HF; Takayama H
    J Med Chem; 2000 Nov; 43(22):4247-65. PubMed ID: 11063621
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Highly potent cell differentiation-inducing analogues of 1alpha,25-dihydroxyvitamin D3: synthesis and biological activity of 2-methyl-1,25-dihydroxyvitamin D3 with side-chain modifications.
    Fujishima T; Zhaopeng L; Konno K; Nakagawa K; Okano T; Yamaguchi K; Takayama H
    Bioorg Med Chem; 2001 Feb; 9(2):525-35. PubMed ID: 11249144
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.
    Yamamoto K; Inaba Y; Yoshimoto N; Choi M; DeLuca HF; Yamada S
    J Med Chem; 2007 Mar; 50(5):932-9. PubMed ID: 17298045
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 20-epi-2-methyl-1alpha,25-dihydroxyvitamin D(3).
    Takayama H; Konno K; Fujishima T; Maki S; Liu Z; Miura D; Chokki M; Ishizuka S; Smith C; DeLuca HF; Nakagawa K; Kurobe M; Okano T
    Steroids; 2001; 66(3-5):277-85. PubMed ID: 11179735
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.
    Anami Y; Sakamaki Y; Itoh T; Inaba Y; Nakabayashi M; Ikura T; Ito N; Yamamoto K
    Bioorg Med Chem; 2015 Nov; 23(22):7274-81. PubMed ID: 26515040
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 13,13-Dimethyl-des-C,D analogues of (20S)-1α,25-dihydroxy-2-methylene-19-norvitamin D₃ (2MD): total synthesis, docking to the VDR, and biological evaluation.
    Plonska-Ocypa K; Sibilska I; Sicinski RR; Sicinska W; Plum LA; DeLuca HF
    Bioorg Med Chem; 2011 Dec; 19(23):7205-20. PubMed ID: 22018918
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Analogs of 1alpha,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs.
    Shimazaki M; Miyamoto Y; Yamamoto K; Yamada S; Takami M; Shinki T; Udagawa N; Shimizu M
    Bioorg Med Chem; 2006 Jul; 14(13):4645-56. PubMed ID: 16513359
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor.
    Inaba Y; Yoshimoto N; Sakamaki Y; Nakabayashi M; Ikura T; Tamamura H; Ito N; Shimizu M; Yamamoto K
    J Med Chem; 2009 Mar; 52(5):1438-49. PubMed ID: 19193059
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and biological properties of seco-d-ring modified 1α,25-dihydroxyvitamin D
    Szybinski M; Sektas K; Sicinski RR; Plum LA; Frelek J; DeLuca HF
    J Steroid Biochem Mol Biol; 2017 Jul; 171():144-154. PubMed ID: 28285018
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-based design of a superagonist ligand for the vitamin D nuclear receptor.
    Hourai S; Rodrigues LC; Antony P; Reina-San-Martin B; Ciesielski F; Magnier BC; Schoonjans K; Mouriño A; Rochel N; Moras D
    Chem Biol; 2008 Apr; 15(4):383-92. PubMed ID: 18420145
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptor.
    Fujishima T; Konno K; Nakagawa K; Tanaka M; Okano T; Kurihara M; Miyata N; Takayama H
    Chem Biol; 2001 Nov; 8(11):1011-24. PubMed ID: 11731293
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group.
    Anami Y; Itoh T; Egawa D; Yoshimoto N; Yamamoto K
    J Med Chem; 2014 May; 57(10):4351-67. PubMed ID: 24742174
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and in vitro evaluation of side chain-unsaturated analogs of 24a,24b-dihomo-1,25-dihydroxycholecalciferol.
    Chodyński M; Wojciechowska W; Halkes SJ; van de Velde JP; Kutner A
    Steroids; 1997 Jul; 62(7):546-53. PubMed ID: 9253795
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Potent antagonist for the vitamin D receptor: vitamin D analogues with simple side chain structure.
    Sakamaki Y; Inaba Y; Yoshimoto N; Yamamoto K
    J Med Chem; 2010 Aug; 53(15):5813-26. PubMed ID: 20608741
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains.
    Fraga R; Zacconi F; Sussman F; Ordóñez-Morán P; Muñoz A; Huet T; Molnár F; Moras D; Rochel N; Maestro M; Mouriño A
    Chemistry; 2012 Jan; 18(2):603-12. PubMed ID: 22162241
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.