BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

350 related articles for article (PubMed ID: 11966461)

  • 1. Secretase as a target for Alzheimer's disease.
    Wolfe MS
    Curr Top Med Chem; 2002 Apr; 2(4):371-83. PubMed ID: 11966461
    [TBL] [Abstract][Full Text] [Related]  

  • 2. gamma-Secretase inhibitors as molecular probes of presenilin function.
    Wolfe MS
    J Mol Neurosci; 2001 Oct; 17(2):199-204. PubMed ID: 11816793
    [TBL] [Abstract][Full Text] [Related]  

  • 3. APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.
    Wolfe MS
    Int Immunopharmacol; 2002 Dec; 2(13-14):1919-29. PubMed ID: 12489805
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
    Esler WP; Kimberly WT; Ostaszewski BL; Diehl TS; Moore CL; Tsai JY; Rahmati T; Xia W; Selkoe DJ; Wolfe MS
    Nat Cell Biol; 2000 Jul; 2(7):428-34. PubMed ID: 10878808
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
    Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
    Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
    [TBL] [Abstract][Full Text] [Related]  

  • 7. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease.
    Tomita T; Iwatsubo T
    Drug News Perspect; 2004 Jun; 17(5):321-5. PubMed ID: 15334182
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A portrait of Alzheimer secretases--new features and familiar faces.
    Esler WP; Wolfe MS
    Science; 2001 Aug; 293(5534):1449-54. PubMed ID: 11520976
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
    Evin G; Sharples RA; Weidemann A; Reinhard FB; Carbone V; Culvenor JG; Holsinger RM; Sernee MF; Beyreuther K; Masters CL
    Biochemistry; 2001 Jul; 40(28):8359-68. PubMed ID: 11444983
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilins as therapeutic targets for the treatment of Alzheimer's disease.
    Golde TE; Younkin SG
    Trends Mol Med; 2001 Jun; 7(6):264-9. PubMed ID: 11378516
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T; Ma G; Cai H; Price DL; Wong PC
    J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Relationship between presenilinase and gamma-secretase.
    Xia W
    Drug News Perspect; 2003 Mar; 16(2):69-74. PubMed ID: 12792666
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
    Esler WP; Kimberly WT; Ostaszewski BL; Ye W; Diehl TS; Selkoe DJ; Wolfe MS
    Proc Natl Acad Sci U S A; 2002 Mar; 99(5):2720-5. PubMed ID: 11867728
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Gamma-secretase--intramembrane protease with a complex.
    Wolfe MS
    Sci Aging Knowledge Environ; 2003 Mar; 2003(11):PE7. PubMed ID: 12844518
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Toward the structure of presenilin/γ-secretase and presenilin homologs.
    Wolfe MS
    Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
    Pasternak SH; Bagshaw RD; Guiral M; Zhang S; Ackerley CA; Pak BJ; Callahan JW; Mahuran DJ
    J Biol Chem; 2003 Jul; 278(29):26687-94. PubMed ID: 12736250
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
    Selkoe DJ
    Proc Natl Acad Sci U S A; 2001 Sep; 98(20):11039-41. PubMed ID: 11572965
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W
    Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
    [TBL] [Abstract][Full Text] [Related]  

  • 20. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
    Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.