These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 11969426)

  • 1. Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces.
    Chang CK; Simplaceanu V; Ho C
    Biochemistry; 2002 Apr; 41(17):5644-55. PubMed ID: 11969426
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An additional H-bond in the alpha 1 beta 2 interface as the structural basis for the low oxygen affinity and high cooperativity of a novel recombinant hemoglobin (beta L105W).
    Fang TY; Simplaceanu V; Tsai CH; Ho NT; Ho C
    Biochemistry; 2000 Nov; 39(45):13708-18. PubMed ID: 11076510
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel recombinant hemoglobin, rHb (beta N108Q), with low oxygen affinity, high cooperativity, and stability against autoxidation.
    Tsai CH; Fang TY; Ho NT; Ho C
    Biochemistry; 2000 Nov; 39(45):13719-29. PubMed ID: 11076511
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteine.
    Cheng Y; Shen TJ; Simplaceanu V; Ho C
    Biochemistry; 2002 Oct; 41(39):11901-13. PubMed ID: 12269835
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effects of substitutions of lysine and aspartic acid for asparagine at beta 108 and of tryptophan for valine at alpha 96 on the structural and functional properties of human normal adult hemoglobin: roles of alpha 1 beta 1 and alpha 1 beta 2 subunit interfaces in the cooperative oxygenation process.
    Tsai CH; Shen TJ; Ho NT; Ho C
    Biochemistry; 1999 Jul; 38(27):8751-61. PubMed ID: 10393550
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Site mutations disrupt inter-helical H-bonds (alpha14W-alpha67T and beta15W-beta72S) involved in kinetic steps in the hemoglobin R-->T transition without altering the free energies of oxygenation.
    Tsai CH; Simplaceanu V; Ho NT; Shen TJ; Wang D; Spiro TG; Ho C
    Biophys Chem; 2003; 100(1-3):131-42. PubMed ID: 12646359
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Site-directed mutagenesis in hemoglobin: test of functional homology of the F9 amino acid residues of hemoglobin alpha and beta chains.
    Mawjood AH; Miyazaki G; Kaneko R; Wada Y; Imai K
    Protein Eng; 2000 Feb; 13(2):113-20. PubMed ID: 10708650
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A biophysical investigation of recombinant hemoglobins with aromatic B10 mutations in the distal heme pockets.
    Wiltrout ME; Giovannelli JL; Simplaceanu V; Lukin JA; Ho NT; Ho C
    Biochemistry; 2005 May; 44(19):7207-17. PubMed ID: 15882059
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Assessment of roles of surface histidyl residues in the molecular basis of the Bohr effect and of beta 143 histidine in the binding of 2,3-bisphosphoglycerate in human normal adult hemoglobin.
    Fang TY; Zou M; Simplaceanu V; Ho NT; Ho C
    Biochemistry; 1999 Oct; 38(40):13423-32. PubMed ID: 10529219
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Contributions of asparagine at alpha 97 to the cooperative oxygenation process of hemoglobin.
    Kim HW; Shen TJ; Ho NT; Zou M; Tam MF; Ho C
    Biochemistry; 1996 May; 35(21):6620-7. PubMed ID: 8639610
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Recombinant hemoglobin(alpha 29leucine --> phenylalanine, alpha 96valine --> tryptophan, beta 108asparagine --> lysine) exhibits low oxygen affinity and high cooperativity combined with resistance to autoxidation.
    Jeong ST; Ho NT; Hendrich MP; Ho C
    Biochemistry; 1999 Oct; 38(40):13433-42. PubMed ID: 10529220
    [TBL] [Abstract][Full Text] [Related]  

  • 12. NMR investigation of the dynamics of tryptophan side-chains in hemoglobins.
    Yuan Y; Simplaceanu V; Lukin JA; Ho C
    J Mol Biol; 2002 Aug; 321(5):863-78. PubMed ID: 12206767
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Contribution of surface histidyl residues in the alpha-chain to the Bohr effect of human normal adult hemoglobin: roles of global electrostatic effects.
    Sun DP; Zou M; Ho NT; Ho C
    Biochemistry; 1997 Jun; 36(22):6663-73. PubMed ID: 9184146
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mutational effects at the subunit interfaces of human hemoglobin: evidence for a unique sensitivity of the T quaternary state to changes in the hinge region of the alpha 1 beta 2 interface.
    Noble RW; Hui HL; Kwiatkowski LD; Paily P; DeYoung A; Wierzba A; Colby JE; Bruno S; Mozzarelli A
    Biochemistry; 2001 Oct; 40(41):12357-68. PubMed ID: 11591155
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Recombinant hemoglobins with low oxygen affinity and high cooperativity.
    Tsai CH; Ho C
    Biophys Chem; 2002 Jul; 98(1-2):15-25. PubMed ID: 12128186
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Significance of beta116 His (G18) at alpha1beta1 contact sites for alphabeta assembly and autoxidation of hemoglobin.
    Adachi K; Yang Y; Lakka V; Wehrli S; Reddy KS; Surrey S
    Biochemistry; 2003 Sep; 42(34):10252-9. PubMed ID: 12939154
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Site-directed mutagenesis in hemoglobin: functional and structural study of the intersubunit hydrogen bond of threonine-38(C3)alpha at the alpha 1-beta 2 interface in human hemoglobin.
    Hashimoto M; Ishimori K; Imai K; Miyazaki G; Morimoto H; Wada Y; Morishima I
    Biochemistry; 1993 Dec; 32(49):13688-95. PubMed ID: 8257703
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins.
    Barrick D; Ho NT; Simplaceanu V; Ho C
    Biochemistry; 2001 Apr; 40(13):3780-95. PubMed ID: 11300758
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Autoxidation and oxygen binding properties of recombinant hemoglobins with substitutions at the αVal-62 or βVal-67 position of the distal heme pocket.
    Tam MF; Rice NW; Maillett DH; Simplaceanu V; Ho NT; Tam TCS; Shen TJ; Ho C
    J Biol Chem; 2013 Aug; 288(35):25512-25521. PubMed ID: 23867463
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Preparation and kinetic characterization of a series of betaW37 variants of human hemoglobin A: evidence for high-affinity T quaternary structures.
    Kwiatkowski LD; Hui HL; Wierzba A; Noble RW; Walder RY; Peterson ES; Sligar SG; Sanders KE
    Biochemistry; 1998 Mar; 37(13):4325-35. PubMed ID: 9521753
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.