These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

98 related articles for article (PubMed ID: 11979520)

  • 1. Surveying a local fitness landscape of a protein with epistatic sites for the study of directed evolution.
    Aita T; Hamamatsu N; Nomiya Y; Uchiyama H; Shibanaka Y; Husimi Y
    Biopolymers; 2002 Jul; 64(2):95-105. PubMed ID: 11979520
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: application to prolyl endopeptidase and thermolysin.
    Aita T; Uchiyama H; Inaoka T; Nakajima M; Kokubo T; Husimi Y
    Biopolymers; 2000 Jul; 54(1):64-79. PubMed ID: 10799982
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fitness spectrum among random mutants on Mt. Fuji-type fitness landscape.
    Aita T; Husimi Y
    J Theor Biol; 1996 Oct; 182(4):469-85. PubMed ID: 8944894
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biased mutation-assembling: an efficient method for rapid directed evolution through simultaneous mutation accumulation.
    Hamamatsu N; Aita T; Nomiya Y; Uchiyama H; Nakajima M; Husimi Y; Shibanaka Y
    Protein Eng Des Sel; 2005 Jun; 18(6):265-71. PubMed ID: 15928005
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Theory of evolutionary molecular engineering through simultaneous accumulation of advantageous mutations.
    Aita T; Husimi Y
    J Theor Biol; 2000 Dec; 207(4):543-56. PubMed ID: 11093838
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Constructing and analyzing the fitness landscape of an experimental evolutionary process.
    Reetz MT; Sanchis J
    Chembiochem; 2008 Sep; 9(14):2260-7. PubMed ID: 18712749
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Extracting characteristic properties of fitness landscape from in vitro molecular evolution: a case study on infectivity of fd phage to E.coli.
    Aita T; Hayashi Y; Toyota H; Husimi Y; Urabe I; Yomo T
    J Theor Biol; 2007 Jun; 246(3):538-50. PubMed ID: 17316695
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy.
    Heinis C; Alessi P; Neri D
    Biochemistry; 2004 May; 43(20):6293-303. PubMed ID: 15147213
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evolution of coadaptation in a two-locus epistatic system.
    Takahasi KR; Tajima F
    Evolution; 2005 Nov; 59(11):2324-32. PubMed ID: 16396173
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Adaptive Walks by the Fittest among Finite Random Mutants on a Mt. Fuji-type Fitness Landscape.
    Aita T; Husimi Y
    J Theor Biol; 1998 Aug; 193(3):383-405. PubMed ID: 9735268
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Directed evolution by accumulating tailored mutations: thermostabilization of lactate oxidase with less trade-off with catalytic activity.
    Hamamatsu N; Nomiya Y; Aita T; Nakajima M; Husimi Y; Shibanaka Y
    Protein Eng Des Sel; 2006 Nov; 19(11):483-9. PubMed ID: 16951411
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Directed molecular evolution by machine learning and the influence of nonlinear interactions.
    Fox R
    J Theor Biol; 2005 May; 234(2):187-99. PubMed ID: 15757678
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A theoretical model of restriction endonuclease NlaIV in complex with DNA, predicted by fold recognition and validated by site-directed mutagenesis and circular dichroism spectroscopy.
    Chmiel AA; Radlinska M; Pawlak SD; Krowarsch D; Bujnicki JM; Skowronek KJ
    Protein Eng Des Sel; 2005 Apr; 18(4):181-9. PubMed ID: 15849215
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Variable epistatic effects between mutations at host recognition sites in phiX174 bacteriophage.
    Pepin KM; Wichman HA
    Evolution; 2007 Jul; 61(7):1710-24. PubMed ID: 17598750
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The biochemical architecture of an ancient adaptive landscape.
    Lunzer M; Miller SP; Felsheim R; Dean AM
    Science; 2005 Oct; 310(5747):499-501. PubMed ID: 16239478
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization.
    Meadows SA; Edosada CY; Mayeda M; Tran T; Quan C; Raab H; Wiesmann C; Wolf BB
    Biochemistry; 2007 Apr; 46(15):4598-605. PubMed ID: 17381073
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Thermodynamical interpretation of evolutionary dynamics on a fitness landscape in an evolution reactor, II.
    Aita T; Morinaga S; Husimi Y
    Bull Math Biol; 2005 May; 67(3):613-35. PubMed ID: 15820744
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Population dynamics simulations of functional model proteins.
    Blackburne BP; Hirst JD
    J Chem Phys; 2005 Oct; 123(15):154907. PubMed ID: 16252972
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vivo molecular evolution reveals biophysical origins of organismal fitness.
    Couñago R; Chen S; Shamoo Y
    Mol Cell; 2006 May; 22(4):441-9. PubMed ID: 16713575
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The effects of mutations in the carboxyl-terminal region on the catalytic activity of Escherichia coli signal peptidase I.
    Kim YT; Yoshida H; Kojima M; Kurita R; Nishii W; Muramatsu T; Ito H; Park SJ; Takahashi K
    J Biochem; 2008 Feb; 143(2):237-42. PubMed ID: 18032415
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.