These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
12. Quinone bioreductive prodrugs as delivery agents. Jaffar M; Abou-Zeid N; Bai L; Mrema I; Robinson I; Tanner R; Stratford IJ Curr Drug Deliv; 2004 Oct; 1(4):345-50. PubMed ID: 16305396 [TBL] [Abstract][Full Text] [Related]
13. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase. Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423 [TBL] [Abstract][Full Text] [Related]
14. The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells. Hasinoff BB; Begleiter A Free Radic Res; 2006 Sep; 40(9):974-8. PubMed ID: 17015278 [TBL] [Abstract][Full Text] [Related]
15. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9. Plumb JA; Gerritsen M; Workman P Br J Cancer; 1994 Dec; 70(6):1136-43. PubMed ID: 7526885 [TBL] [Abstract][Full Text] [Related]
16. The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions. Saunders MP; Jaffar M; Patterson AV; Nolan J; Naylor MA; Phillips RM; Harris AL; Stratford IJ Biochem Pharmacol; 2000 Apr; 59(8):993-6. PubMed ID: 10692564 [TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs. Dragovich PS; Broccatelli F; Chen J; Fan P; Le H; Mao W; Pillow TH; Polson AG; Wai J; Xu Z; Yao H; Zhang D Bioorg Med Chem Lett; 2017 Dec; 27(23):5300-5304. PubMed ID: 29079474 [TBL] [Abstract][Full Text] [Related]
18. Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs. Shen X; Laber CH; Sarkar U; Galazzi F; Johnson KM; Mahieu NG; Hillebrand R; Fuchs-Knotts T; Barnes CL; Baker GA; Gates KS J Org Chem; 2018 Mar; 83(6):3126-3131. PubMed ID: 29461834 [TBL] [Abstract][Full Text] [Related]
19. Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species. Bailey SM; Lewis AD; Patterson LH; Fisher GR; Knox RJ; Workman P Biochem Pharmacol; 2001 Aug; 62(4):461-8. PubMed ID: 11448456 [TBL] [Abstract][Full Text] [Related]
20. 1,2-benzisoxazole phosphorodiamidates as novel anticancer prodrugs requiring bioreductive activation. Jain M; Kwon CH J Med Chem; 2003 Dec; 46(25):5428-36. PubMed ID: 14640551 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]