BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

456 related articles for article (PubMed ID: 12021443)

  • 1. Role of water in the catalytic cycle of E. coli dihydrofolate reductase.
    Shrimpton P; Allemann RK
    Protein Sci; 2002 Jun; 11(6):1442-51. PubMed ID: 12021443
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Functional role for Tyr 31 in the catalytic cycle of chicken dihydrofolate reductase.
    Shrimpton P; Mullaney A; Allemann RK
    Proteins; 2003 May; 51(2):216-23. PubMed ID: 12660990
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase.
    Cummins PL; Gready JE
    J Am Chem Soc; 2001 Apr; 123(15):3418-28. PubMed ID: 11472112
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.
    Wan Q; Bennett BC; Wilson MA; Kovalevsky A; Langan P; Howell EE; Dealwis C
    Proc Natl Acad Sci U S A; 2014 Dec; 111(51):18225-30. PubMed ID: 25453083
    [TBL] [Abstract][Full Text] [Related]  

  • 5. How dihydrofolate reductase facilitates protonation of dihydrofolate.
    Rod TH; Brooks CL
    J Am Chem Soc; 2003 Jul; 125(29):8718-9. PubMed ID: 12862454
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.
    Lee H; Reyes VM; Kraut J
    Biochemistry; 1996 Jun; 35(22):7012-20. PubMed ID: 8679526
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
    Sawaya MR; Kraut J
    Biochemistry; 1997 Jan; 36(3):586-603. PubMed ID: 9012674
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.
    Venkitakrishnan RP; Zaborowski E; McElheny D; Benkovic SJ; Dyson HJ; Wright PE
    Biochemistry; 2004 Dec; 43(51):16046-55. PubMed ID: 15609999
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.
    McTigue MA; Davies JF; Kaufman BT; Kraut J
    Biochemistry; 1992 Aug; 31(32):7264-73. PubMed ID: 1510919
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of the Met
    Mhashal AR; Vardi-Kilshtain A; Kohen A; Major DT
    J Biol Chem; 2017 Aug; 292(34):14229-14239. PubMed ID: 28620051
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
    Reyes VM; Sawaya MR; Brown KA; Kraut J
    Biochemistry; 1995 Feb; 34(8):2710-23. PubMed ID: 7873554
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
    Cody V; Galitsky N; Rak D; Luft JR; Pangborn W; Queener SF
    Biochemistry; 1999 Apr; 38(14):4303-12. PubMed ID: 10194348
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pKa of the bound dihydrofolate.
    Khavrutskii IV; Price DJ; Lee J; Brooks CL
    Protein Sci; 2007 Jun; 16(6):1087-100. PubMed ID: 17473015
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications.
    Chen YQ; Kraut J; Blakley RL; Callender R
    Biochemistry; 1994 Jun; 33(23):7021-6. PubMed ID: 8003467
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Light activates reduction of methotrexate by NADPH in the ternary complex with Escherichia coli dihydrofolate reductase.
    Chen YQ; Gulotta M; Cheung HT; Callender R
    Photochem Photobiol; 1999 Jan; 69(1):77-85. PubMed ID: 10063803
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Vibrational structure of dihydrofolate bound to R67 dihydrofolate reductase.
    Deng H; Callender R; Howell E
    J Biol Chem; 2001 Dec; 276(52):48956-60. PubMed ID: 11679579
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism.
    Osborne MJ; Schnell J; Benkovic SJ; Dyson HJ; Wright PE
    Biochemistry; 2001 Aug; 40(33):9846-59. PubMed ID: 11502178
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase.
    Miller GP; Benkovic SJ
    Biochemistry; 1998 May; 37(18):6336-42. PubMed ID: 9572848
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Detection of long-lived bound water molecules in complexes of human dihydrofolate reductase with methotrexate and NADPH.
    Meiering EM; Wagner G
    J Mol Biol; 1995 Mar; 247(2):294-308. PubMed ID: 7707376
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase.
    Schnell JR; Dyson HJ; Wright PE
    Biochemistry; 2004 Jan; 43(2):374-83. PubMed ID: 14717591
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.