456 related articles for article (PubMed ID: 12021443)
1. Role of water in the catalytic cycle of E. coli dihydrofolate reductase.
Shrimpton P; Allemann RK
Protein Sci; 2002 Jun; 11(6):1442-51. PubMed ID: 12021443
[TBL] [Abstract][Full Text] [Related]
2. Functional role for Tyr 31 in the catalytic cycle of chicken dihydrofolate reductase.
Shrimpton P; Mullaney A; Allemann RK
Proteins; 2003 May; 51(2):216-23. PubMed ID: 12660990
[TBL] [Abstract][Full Text] [Related]
3. Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase.
Cummins PL; Gready JE
J Am Chem Soc; 2001 Apr; 123(15):3418-28. PubMed ID: 11472112
[TBL] [Abstract][Full Text] [Related]
4. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.
Wan Q; Bennett BC; Wilson MA; Kovalevsky A; Langan P; Howell EE; Dealwis C
Proc Natl Acad Sci U S A; 2014 Dec; 111(51):18225-30. PubMed ID: 25453083
[TBL] [Abstract][Full Text] [Related]
5. How dihydrofolate reductase facilitates protonation of dihydrofolate.
Rod TH; Brooks CL
J Am Chem Soc; 2003 Jul; 125(29):8718-9. PubMed ID: 12862454
[TBL] [Abstract][Full Text] [Related]
6. Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.
Lee H; Reyes VM; Kraut J
Biochemistry; 1996 Jun; 35(22):7012-20. PubMed ID: 8679526
[TBL] [Abstract][Full Text] [Related]
7. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Sawaya MR; Kraut J
Biochemistry; 1997 Jan; 36(3):586-603. PubMed ID: 9012674
[TBL] [Abstract][Full Text] [Related]
8. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.
Venkitakrishnan RP; Zaborowski E; McElheny D; Benkovic SJ; Dyson HJ; Wright PE
Biochemistry; 2004 Dec; 43(51):16046-55. PubMed ID: 15609999
[TBL] [Abstract][Full Text] [Related]
9. Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.
McTigue MA; Davies JF; Kaufman BT; Kraut J
Biochemistry; 1992 Aug; 31(32):7264-73. PubMed ID: 1510919
[TBL] [Abstract][Full Text] [Related]
10. The role of the Met
Mhashal AR; Vardi-Kilshtain A; Kohen A; Major DT
J Biol Chem; 2017 Aug; 292(34):14229-14239. PubMed ID: 28620051
[TBL] [Abstract][Full Text] [Related]
11. Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Reyes VM; Sawaya MR; Brown KA; Kraut J
Biochemistry; 1995 Feb; 34(8):2710-23. PubMed ID: 7873554
[TBL] [Abstract][Full Text] [Related]
12. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
Cody V; Galitsky N; Rak D; Luft JR; Pangborn W; Queener SF
Biochemistry; 1999 Apr; 38(14):4303-12. PubMed ID: 10194348
[TBL] [Abstract][Full Text] [Related]
13. Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pKa of the bound dihydrofolate.
Khavrutskii IV; Price DJ; Lee J; Brooks CL
Protein Sci; 2007 Jun; 16(6):1087-100. PubMed ID: 17473015
[TBL] [Abstract][Full Text] [Related]
14. Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications.
Chen YQ; Kraut J; Blakley RL; Callender R
Biochemistry; 1994 Jun; 33(23):7021-6. PubMed ID: 8003467
[TBL] [Abstract][Full Text] [Related]
15. Light activates reduction of methotrexate by NADPH in the ternary complex with Escherichia coli dihydrofolate reductase.
Chen YQ; Gulotta M; Cheung HT; Callender R
Photochem Photobiol; 1999 Jan; 69(1):77-85. PubMed ID: 10063803
[TBL] [Abstract][Full Text] [Related]
16. Vibrational structure of dihydrofolate bound to R67 dihydrofolate reductase.
Deng H; Callender R; Howell E
J Biol Chem; 2001 Dec; 276(52):48956-60. PubMed ID: 11679579
[TBL] [Abstract][Full Text] [Related]
17. Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism.
Osborne MJ; Schnell J; Benkovic SJ; Dyson HJ; Wright PE
Biochemistry; 2001 Aug; 40(33):9846-59. PubMed ID: 11502178
[TBL] [Abstract][Full Text] [Related]
18. Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase.
Miller GP; Benkovic SJ
Biochemistry; 1998 May; 37(18):6336-42. PubMed ID: 9572848
[TBL] [Abstract][Full Text] [Related]
19. Detection of long-lived bound water molecules in complexes of human dihydrofolate reductase with methotrexate and NADPH.
Meiering EM; Wagner G
J Mol Biol; 1995 Mar; 247(2):294-308. PubMed ID: 7707376
[TBL] [Abstract][Full Text] [Related]
20. Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase.
Schnell JR; Dyson HJ; Wright PE
Biochemistry; 2004 Jan; 43(2):374-83. PubMed ID: 14717591
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]