BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

374 related articles for article (PubMed ID: 12021785)

  • 1. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
    Bulavin DV; Demidov ON; Saito S; Kauraniemi P; Phillips C; Amundson SA; Ambrosino C; Sauter G; Nebreda AR; Anderson CW; Kallioniemi A; Fornace AJ; Appella E
    Nat Genet; 2002 Jun; 31(2):210-5. PubMed ID: 12021785
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers.
    Yu E; Ahn YS; Jang SJ; Kim MJ; Yoon HS; Gong G; Choi J
    Breast Cancer Res Treat; 2007 Mar; 101(3):269-78. PubMed ID: 16897432
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PP2Cdelta (Ppm1d, WIP1), an endogenous inhibitor of p38 MAPK, is regulated along with Trp53 and Cdkn2a following p38 MAPK inhibition during mouse preimplantation development.
    Hickson JA; Fong B; Watson PH; Watson AJ
    Mol Reprod Dev; 2007 Jul; 74(7):821-34. PubMed ID: 17219434
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
    Nannenga B; Lu X; Dumble M; Van Maanen M; Nguyen TA; Sutton R; Kumar TR; Donehower LA
    Mol Carcinog; 2006 Aug; 45(8):594-604. PubMed ID: 16652371
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dual roles for the phosphatase PPM1D in regulating progesterone receptor function.
    Proia DA; Nannenga BW; Donehower LA; Weigel NL
    J Biol Chem; 2006 Mar; 281(11):7089-101. PubMed ID: 16352595
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
    Lu X; Nguyen TA; Donehower LA
    Cell Cycle; 2005 Aug; 4(8):1060-4. PubMed ID: 15970689
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours.
    Rauta J; Alarmo EL; Kauraniemi P; Karhu R; Kuukasjärvi T; Kallioniemi A
    Breast Cancer Res Treat; 2006 Feb; 95(3):257-63. PubMed ID: 16254685
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
    Bulavin DV; Phillips C; Nannenga B; Timofeev O; Donehower LA; Anderson CW; Appella E; Fornace AJ
    Nat Genet; 2004 Apr; 36(4):343-50. PubMed ID: 14991053
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
    Li J; Yang Y; Peng Y; Austin RJ; van Eyndhoven WG; Nguyen KC; Gabriele T; McCurrach ME; Marks JR; Hoey T; Lowe SW; Powers S
    Nat Genet; 2002 Jun; 31(2):133-4. PubMed ID: 12021784
    [TBL] [Abstract][Full Text] [Related]  

  • 10. PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53.
    Pärssinen J; Alarmo EL; Karhu R; Kallioniemi A
    Cancer Genet Cytogenet; 2008 Apr; 182(1):33-9. PubMed ID: 18328948
    [TBL] [Abstract][Full Text] [Related]  

  • 11. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.
    Zhang M; Xu E; Zhang J; Chen X
    Oncogene; 2015 Nov; 34(48):5900-11. PubMed ID: 25823026
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Silencing of PPM1D inhibits cell proliferation and invasion through the p38 MAPK and p53 signaling pathway in papillary thyroid carcinoma.
    Lu ZW; Wen D; Wei WJ; Han LT; Xiang J; Wang YL; Wang Y; Liao T; Ji QH
    Oncol Rep; 2020 Mar; 43(3):783-794. PubMed ID: 31922231
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation.
    Ali AY; Abedini MR; Tsang BK
    Oncogene; 2012 Apr; 31(17):2175-86. PubMed ID: 21927021
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of differentially expressed genes after PPM1D silencing in breast cancer.
    Pärssinen J; Alarmo EL; Khan S; Karhu R; Vihinen M; Kallioniemi A
    Cancer Lett; 2008 Jan; 259(1):61-70. PubMed ID: 17977650
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
    Lu X; Nannenga B; Donehower LA
    Genes Dev; 2005 May; 19(10):1162-74. PubMed ID: 15870257
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.
    Yagi H; Chuman Y; Kozakai Y; Imagawa T; Takahashi Y; Yoshimura F; Tanino K; Sakaguchi K
    Bioorg Med Chem Lett; 2012 Jan; 22(1):729-32. PubMed ID: 22115592
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PPM1D exerts its oncogenic properties in human pancreatic cancer through multiple mechanisms.
    Wu B; Guo BM; Kang J; Deng XZ; Fan YB; Zhang XP; Ai KX
    Apoptosis; 2016 Mar; 21(3):365-78. PubMed ID: 26714478
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression.
    Han HS; Yu E; Song JY; Park JY; Jang SJ; Choi J
    Mol Cancer Res; 2009 May; 7(5):713-23. PubMed ID: 19435816
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.
    Lu X; Nguyen TA; Appella E; Donehower LA
    Cell Cycle; 2004 Nov; 3(11):1363-6. PubMed ID: 15539943
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.
    Bulavin DV; Saito S; Hollander MC; Sakaguchi K; Anderson CW; Appella E; Fornace AJ
    EMBO J; 1999 Dec; 18(23):6845-54. PubMed ID: 10581258
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.