These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

193 related articles for article (PubMed ID: 12028664)

  • 1. Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure.
    Lewis DF
    Xenobiotica; 2002 Apr; 32(4):305-23. PubMed ID: 12028664
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
    Lewis DF
    Arch Biochem Biophys; 2003 Jan; 409(1):32-44. PubMed ID: 12464242
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Investigating human P450s involved in drug metabolism via homology with high-resolution P450 crystal structures of the CYP2C subfamily.
    Lewis DF; Ito Y; Goldfarb PS
    Curr Drug Metab; 2006 Aug; 7(6):589-98. PubMed ID: 16918314
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity.
    Lewis DF
    Exp Toxicol Pathol; 1999 Jul; 51(4-5):369-74. PubMed ID: 10445400
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular modelling of CYP2B6 based on homology with the CYP2C5 crystal structure: analysis of enzyme-substrate interactions.
    Lewis DF; Lake BG; Dickins M; Goldfarb PS
    Drug Metabol Drug Interact; 2002; 19(2):115-35. PubMed ID: 12751910
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substrates of human cytochromes P450 from families CYP1 and CYP2: analysis of enzyme selectivity and metabolism.
    Lewis DF; Lake BG; Dickins M
    Drug Metabol Drug Interact; 2004; 20(3):111-42. PubMed ID: 15508429
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.
    Lewis DF; Lake BG; Dickins M; Eddershaw PJ; Tarbit MH; Goldfarb PS
    Xenobiotica; 1999 Apr; 29(4):361-93. PubMed ID: 10375007
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.
    Marques-Soares C; Dijols S; Macherey AC; Wester MR; Johnson EF; Dansette PM; Mansuy D
    Biochemistry; 2003 Jun; 42(21):6363-9. PubMed ID: 12767217
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Investigation of enzyme selectivity in the human CYP2C subfamily: homology modelling of CYP2C8, CYP2C9 and CYP2C19 from the CYP2C5 crystallographic template.
    Lewis DF; Dickins M; Lake BG; Goldfarb PS
    Drug Metabol Drug Interact; 2003; 19(4):257-85. PubMed ID: 14768974
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure conservation in cytochromes P450.
    Mestres J
    Proteins; 2005 Feb; 58(3):596-609. PubMed ID: 15617063
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Homology modelling of CYP2A6 based on the CYP2C5 crystallographic template: enzyme-substrate interactions and QSARs for binding affinity and inhibition.
    Lewis DF; Lake BG; Dickins M; Goldfarb PS
    Toxicol In Vitro; 2003 Apr; 17(2):179-90. PubMed ID: 12650672
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Modelling human cytochromes P450 involved in drug metabolism from the CYP2C5 crystallographic template.
    Lewis DF
    J Inorg Biochem; 2002 Sep; 91(4):502-14. PubMed ID: 12237218
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily.
    Lewis DF; Dickins M; Weaver RJ; Eddershaw PJ; Goldfarb PS; Tarbit MH
    Xenobiotica; 1998 Mar; 28(3):235-68. PubMed ID: 9574814
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development of a combined protein and pharmacophore model for cytochrome P450 2C9.
    de Groot MJ; Alex AA; Jones BC
    J Med Chem; 2002 May; 45(10):1983-93. PubMed ID: 11985466
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A molecular model of CYP2D6 constructed by homology with the CYP2C5 crystallographic template: investigation of enzyme-substrate interactions.
    Lewis DF; Dickins M; Lake BG; Goldfarb PS
    Drug Metabol Drug Interact; 2003; 19(3):189-210. PubMed ID: 14682610
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
    Smith G; Modi S; Pillai I; Lian LY; Sutcliffe MJ; Pritchard MP; Friedberg T; Roberts GC; Wolf CR
    Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):783-92. PubMed ID: 9560305
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.
    Sahi J; Black CB; Hamilton GA; Zheng X; Jolley S; Rose KA; Gilbert D; LeCluyse EL; Sinz MW
    Drug Metab Dispos; 2003 Apr; 31(4):439-46. PubMed ID: 12642470
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analysis of selective regions in the active sites of human cytochromes P450, 2C8, 2C9, 2C18, and 2C19 homology models using GRID/CPCA.
    Ridderström M; Zamora I; Fjellström O; Andersson TB
    J Med Chem; 2001 Nov; 44(24):4072-81. PubMed ID: 11708911
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.
    Ring BJ; Eckstein JA; Gillespie JS; Binkley SN; VandenBranden M; Wrighton SA
    J Pharmacol Exp Ther; 2001 Jun; 297(3):1044-50. PubMed ID: 11356927
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions.
    Lewis DF; Lake BG; Dickins M; Goldfarb PS
    Xenobiotica; 2004 Jun; 34(6):549-69. PubMed ID: 15277015
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.