697 related articles for article (PubMed ID: 12045208)
1. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.
Albuquerque C; Breukel C; van der Luijt R; Fidalgo P; Lage P; Slors FJ; Leitão CN; Fodde R; Smits R
Hum Mol Genet; 2002 Jun; 11(13):1549-60. PubMed ID: 12045208
[TBL] [Abstract][Full Text] [Related]
2. Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
Crabtree M; Sieber OM; Lipton L; Hodgson SV; Lamlum H; Thomas HJ; Neale K; Phillips RK; Heinimann K; Tomlinson IP
Oncogene; 2003 Jul; 22(27):4257-65. PubMed ID: 12833148
[TBL] [Abstract][Full Text] [Related]
3. APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.
Latchford A; Volikos E; Johnson V; Rogers P; Suraweera N; Tomlinson I; Phillips R; Silver A
Hum Mol Genet; 2007 Jan; 16(1):78-82. PubMed ID: 17135276
[TBL] [Abstract][Full Text] [Related]
4. [Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms].
Friedrich A; Kullmann F
Med Klin (Munich); 2003 Dec; 98(12):776-82. PubMed ID: 14685680
[TBL] [Abstract][Full Text] [Related]
5. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
Lamlum H; Ilyas M; Rowan A; Clark S; Johnson V; Bell J; Frayling I; Efstathiou J; Pack K; Payne S; Roylance R; Gorman P; Sheer D; Neale K; Phillips R; Talbot I; Bodmer W; Tomlinson I
Nat Med; 1999 Sep; 5(9):1071-5. PubMed ID: 10470088
[TBL] [Abstract][Full Text] [Related]
6. Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas.
Venesio T; Balsamo A; Scordamaglia A; Bertolaso M; Arrigoni A; Sprujevnik T; Rossini FP; Risio M
Mod Pathol; 2003 Jan; 16(1):57-65. PubMed ID: 12527714
[TBL] [Abstract][Full Text] [Related]
7. Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
Abraham SC; Wu TT; Klimstra DS; Finn LS; Lee JH; Yeo CJ; Cameron JL; Hruban RH
Am J Pathol; 2001 Nov; 159(5):1619-27. PubMed ID: 11696422
[TBL] [Abstract][Full Text] [Related]
8. Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours.
Kohler EM; Chandra SH; Behrens J; Schneikert J
Hum Mol Genet; 2009 Jan; 18(2):213-26. PubMed ID: 18854359
[TBL] [Abstract][Full Text] [Related]
9. The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells.
Yedid N; Kalma Y; Malcov M; Amit A; Kariv R; Caspi M; Rosin-Arbesfeld R; Ben-Yosef D
BMC Cancer; 2016 Dec; 16(1):952. PubMed ID: 28010732
[TBL] [Abstract][Full Text] [Related]
10. Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.
Groves C; Lamlum H; Crabtree M; Williamson J; Taylor C; Bass S; Cuthbert-Heavens D; Hodgson S; Phillips R; Tomlinson I
Am J Pathol; 2002 Jun; 160(6):2055-61. PubMed ID: 12057910
[TBL] [Abstract][Full Text] [Related]
11. Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
Su LK; Barnes CJ; Yao W; Qi Y; Lynch PM; Steinbach G
Am J Hum Genet; 2000 Sep; 67(3):582-90. PubMed ID: 10924409
[TBL] [Abstract][Full Text] [Related]
12. Somatic mutations in familial adenomatous polyps. Nuclear translocation of beta-catenin requires more than biallelic APC inactivation.
Bläker H; Scholten M; Sutter C; Otto HF; Penzel R
Am J Clin Pathol; 2003 Sep; 120(3):418-23. PubMed ID: 14502807
[TBL] [Abstract][Full Text] [Related]
13. different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli.
Schneikert J; Ruppert JG; Behrens J; Wenzel EM
PLoS One; 2014; 9(4):e94413. PubMed ID: 24722208
[TBL] [Abstract][Full Text] [Related]
14. Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis.
Hu PJ; Knoepp SM; Wu R; Cho KR
Genes Chromosomes Cancer; 2012 Mar; 51(3):283-9. PubMed ID: 22120905
[TBL] [Abstract][Full Text] [Related]
15. Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype.
Miyaki M; Yamaguchi T; Iijima T; Takahashi K; Matsumoto H; Yasutome M; Funata N; Mori T
Int J Cancer; 2008 Jun; 122(11):2491-7. PubMed ID: 18224684
[TBL] [Abstract][Full Text] [Related]
16. APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.
Schneikert J; Brauburger K; Behrens J
Hum Mol Genet; 2011 Sep; 20(18):3554-64. PubMed ID: 21665989
[TBL] [Abstract][Full Text] [Related]
17. Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.
Smits R; Hofland N; Edelmann W; Geugien M; Jagmohan-Changur S; Albuquerque C; Breukel C; Kucherlapati R; Kielman MF; Fodde R
Genes Chromosomes Cancer; 2000 Nov; 29(3):229-39. PubMed ID: 10992298
[TBL] [Abstract][Full Text] [Related]
18. Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients.
Kohler EM; Brauburger K; Behrens J; Schneikert J
Oncogene; 2010 Mar; 29(11):1663-71. PubMed ID: 19966865
[TBL] [Abstract][Full Text] [Related]
19. Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas.
Obrador-Hevia A; Chin SF; González S; Rees J; Vilardell F; Greenson JK; Cordero D; Moreno V; Caldas C; Capellá G
J Pathol; 2010 May; 221(1):57-67. PubMed ID: 20196079
[TBL] [Abstract][Full Text] [Related]
20. Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
Sieber OM; Segditsas S; Knudsen AL; Zhang J; Luz J; Rowan AJ; Spain SL; Thirlwell C; Howarth KM; Jaeger EE; Robinson J; Volikos E; Silver A; Kelly G; Aretz S; Frayling I; Hutter P; Dunlop M; Guenther T; Neale K; Phillips R; Heinimann K; Tomlinson IP
Gut; 2006 Oct; 55(10):1440-8. PubMed ID: 16461775
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
