559 related articles for article (PubMed ID: 12048257)
1. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy.
Danesh FR; Sadeghi MM; Amro N; Philips C; Zeng L; Lin S; Sahai A; Kanwar YS
Proc Natl Acad Sci U S A; 2002 Jun; 99(12):8301-5. PubMed ID: 12048257
[TBL] [Abstract][Full Text] [Related]
2. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1).
Laufs U; Marra D; Node K; Liao JK
J Biol Chem; 1999 Jul; 274(31):21926-31. PubMed ID: 10419514
[TBL] [Abstract][Full Text] [Related]
3. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.
Park HJ; Kong D; Iruela-Arispe L; Begley U; Tang D; Galper JB
Circ Res; 2002 Jul; 91(2):143-50. PubMed ID: 12142347
[TBL] [Abstract][Full Text] [Related]
4. Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway.
Zhong WB; Hsu SP; Ho PY; Liang YC; Chang TC; Lee WS
Biochem Pharmacol; 2011 Dec; 82(11):1663-72. PubMed ID: 21907187
[TBL] [Abstract][Full Text] [Related]
5. Effect of simvastatin on proliferative nephritis and cell-cycle protein expression.
Yoshimura A; Nemoto T; Sugenoya Y; Inui K; Watanabe S; Inoue Y; Sharif S; Yokota N; Uda S; Morita H; Ideura T
Kidney Int Suppl; 1999 Jul; 71():S84-7. PubMed ID: 10412745
[TBL] [Abstract][Full Text] [Related]
6. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.
Ghittoni R; Patrussi L; Pirozzi K; Pellegrini M; Lazzerini PE; Capecchi PL; Pasini FL; Baldari CT
FASEB J; 2005 Apr; 19(6):605-7. PubMed ID: 15677697
[TBL] [Abstract][Full Text] [Related]
7. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
Lee MH; Cho YS; Han YM
Stem Cells; 2007 Jul; 25(7):1654-63. PubMed ID: 17464088
[TBL] [Abstract][Full Text] [Related]
8. Simvastatin alleviates hyperpermeability of glomerular endothelial cells in early-stage diabetic nephropathy by inhibition of RhoA/ROCK1.
Peng H; Luo P; Li Y; Wang C; Liu X; Ye Z; Li C; Lou T
PLoS One; 2013; 8(11):e80009. PubMed ID: 24244596
[TBL] [Abstract][Full Text] [Related]
9. HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway.
Fuchs D; Berges C; Opelz G; Daniel V; Naujokat C
Biochem Biophys Res Commun; 2008 Sep; 374(2):309-14. PubMed ID: 18625202
[TBL] [Abstract][Full Text] [Related]
10. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.
Takeda N; Kondo M; Ito S; Ito Y; Shimokata K; Kume H
Am J Respir Cell Mol Biol; 2006 Dec; 35(6):722-9. PubMed ID: 16858009
[TBL] [Abstract][Full Text] [Related]
11. HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways.
Rupérez M; Rodrigues-Díez R; Blanco-Colio LM; Sánchez-López E; Rodríguez-Vita J; Esteban V; Carvajal G; Plaza JJ; Egido J; Ruiz-Ortega M
Hypertension; 2007 Aug; 50(2):377-83. PubMed ID: 17592071
[TBL] [Abstract][Full Text] [Related]
12. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture.
Guijarro C; Blanco-Colio LM; Ortego M; Alonso C; Ortiz A; Plaza JJ; Díaz C; Hernández G; Egido J
Circ Res; 1998 Sep; 83(5):490-500. PubMed ID: 9734471
[TBL] [Abstract][Full Text] [Related]
13. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation.
Zeng L; Xu H; Chew TL; Eng E; Sadeghi MM; Adler S; Kanwar YS; Danesh FR
FASEB J; 2005 Nov; 19(13):1845-7. PubMed ID: 16160062
[TBL] [Abstract][Full Text] [Related]
14. RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.
Peng F; Wu D; Gao B; Ingram AJ; Zhang B; Chorneyko K; McKenzie R; Krepinsky JC
Diabetes; 2008 Jun; 57(6):1683-92. PubMed ID: 18356410
[TBL] [Abstract][Full Text] [Related]
15. Simvastatin inhibits cell cycle progression in glucose-stimulated proliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53.
Chan KC; Wang CJ; Ho HH; Chen HM; Huang CN
Pharmacol Res; 2008; 58(3-4):247-56. PubMed ID: 18804536
[TBL] [Abstract][Full Text] [Related]
16. Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Maeda T; Horiuchi N
J Biochem; 2009 Jun; 145(6):771-81. PubMed ID: 19254925
[TBL] [Abstract][Full Text] [Related]
17. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway.
Yamashita M; Otsuka F; Mukai T; Otani H; Inagaki K; Miyoshi T; Goto J; Yamamura M; Makino H
J Endocrinol; 2008 Mar; 196(3):601-13. PubMed ID: 18310456
[TBL] [Abstract][Full Text] [Related]
18. Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I.
Martin G; Duez H; Blanquart C; Berezowski V; Poulain P; Fruchart JC; Najib-Fruchart J; Glineur C; Staels B
J Clin Invest; 2001 Jun; 107(11):1423-32. PubMed ID: 11390424
[TBL] [Abstract][Full Text] [Related]
19. The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase.
Schmidmaier R; Baumann P; Simsek M; Dayyani F; Emmerich B; Meinhardt G
Blood; 2004 Sep; 104(6):1825-32. PubMed ID: 15161667
[TBL] [Abstract][Full Text] [Related]
20. Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27.
Zeng L; Xu H; Chew TL; Chisholm R; Sadeghi MM; Kanwar YS; Danesh FR
J Am Soc Nephrol; 2004 Jul; 15(7):1711-20. PubMed ID: 15213258
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]