172 related articles for article (PubMed ID: 12052195)
1. Application of ligand SAR, receptor modeling and receptor mutagenesis to the discovery and development of a new class of 5-HT(2A) ligands.
Westkaemper RB; Glennon RA
Curr Top Med Chem; 2002 Jun; 2(6):575-98. PubMed ID: 12052195
[TBL] [Abstract][Full Text] [Related]
2. Spiro[9,10-dihydroanthracene]-9,3'-pyrrolidine-a structurally unique tetracyclic 5-HT2A receptor antagonist.
Peddi S; Roth BL; Glennon RA; Westkaemper RB
Eur J Pharmacol; 2003 Dec; 482(1-3):335-7. PubMed ID: 14660041
[TBL] [Abstract][Full Text] [Related]
3. 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist.
Westkaemper RB; Runyon SP; Bondarev ML; Savage JE; Roth BL; Glennon RA
Eur J Pharmacol; 1999 Sep; 380(1):R5-7. PubMed ID: 10513561
[TBL] [Abstract][Full Text] [Related]
4. Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.
Runyon SP; Savage JE; Taroua M; Roth BL; Glennon RA; Westkaemper RB
Bioorg Med Chem Lett; 2001 Mar; 11(5):655-8. PubMed ID: 11266163
[TBL] [Abstract][Full Text] [Related]
5. Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.
Runyon SP; Peddi S; Savage JE; Roth BL; Glennon RA; Westkaemper RB
J Med Chem; 2002 Apr; 45(8):1656-64. PubMed ID: 11931619
[TBL] [Abstract][Full Text] [Related]
6. Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.
Runyon SP; Mosier PD; Roth BL; Glennon RA; Westkaemper RB
J Med Chem; 2008 Nov; 51(21):6808-28. PubMed ID: 18847250
[TBL] [Abstract][Full Text] [Related]
7. Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists.
Glennon RA; Metwally K; Dukat M; Ismaiel AM; De los Angeles J; Herndon J; Teitler M; Khorana N
Curr Top Med Chem; 2002 Jun; 2(6):539-58. PubMed ID: 12052193
[TBL] [Abstract][Full Text] [Related]
8. Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.
Westkaemper RB; Runyon SP; Savage JE; Roth BL; Glennon RA
Bioorg Med Chem Lett; 2001 Feb; 11(4):563-6. PubMed ID: 11229772
[TBL] [Abstract][Full Text] [Related]
9. 5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions.
López-Rodriguez ML; Benhamú B; Morcillo MJ; Murcia M; Viso A; Campillo M; Pardob L
Curr Top Med Chem; 2002 Jun; 2(6):625-41. PubMed ID: 12052197
[TBL] [Abstract][Full Text] [Related]
10. 9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites.
Shah JR; Mosier PD; Peddi S; Roth BL; Westkaemper RB
Bioorg Med Chem Lett; 2010 Feb; 20(3):935-8. PubMed ID: 20045641
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.
Shah JR; Mosier PD; Roth BL; Kellogg GE; Westkaemper RB
Bioorg Med Chem; 2009 Sep; 17(18):6496-504. PubMed ID: 19700330
[TBL] [Abstract][Full Text] [Related]
12. New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
Brea J; Rodrigo J; Carrieri A; Sanz F; Cadavid MI; Enguix MJ; Villazón M; Mengod G; Caro Y; Masaguer CF; Raviña E; Centeno NB; Carotti A; Loza MI
J Med Chem; 2002 Jan; 45(1):54-71. PubMed ID: 11754579
[TBL] [Abstract][Full Text] [Related]
13. Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.
Campiani G; Butini S; Fattorusso C; Catalanotti B; Gemma S; Nacci V; Morelli E; Cagnotto A; Mereghetti I; Mennini T; Carli M; Minetti P; Di Cesare MA; Mastroianni D; Scafetta N; Galletti B; Stasi MA; Castorina M; Pacifici L; Vertechy M; Di Serio S; Ghirardi O; Tinti O; Carminati P
J Med Chem; 2004 Jan; 47(1):143-57. PubMed ID: 14695828
[TBL] [Abstract][Full Text] [Related]
14. Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling.
Rashid M; Manivet P; Nishio H; Pratuangdejkul J; Rajab M; Ishiguro M; Launay JM; Nagatomo T
Life Sci; 2003 May; 73(2):193-207. PubMed ID: 12738034
[TBL] [Abstract][Full Text] [Related]
15. 1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character.
Rangisetty JB; Dukat M; Dowd CS; Herrick-Davis K; DuPre A; Gadepalli S; Teitler M; Kelley CR; Sharif NA; Glennon RA
J Med Chem; 2001 Sep; 44(20):3283-91. PubMed ID: 11563927
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.
López-Rodríguez ML; Morcillo MJ; Fernández E; Rosado ML; Pardo L; Schaper K
J Med Chem; 2001 Jan; 44(2):198-207. PubMed ID: 11170629
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.
Asproni B; Pau A; Bitti M; Melosu M; Cerri R; Dazzi L; Seu E; Maciocco E; Sanna E; Busonero F; Talani G; Pusceddu L; Altomare C; Trapani G; Biggio G
J Med Chem; 2002 Oct; 45(21):4655-68. PubMed ID: 12361392
[TBL] [Abstract][Full Text] [Related]
18. 2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands.
Wilson KJ; van Niel MB; Cooper L; Bloomfield D; O'Connor D; Fish LR; MacLeod AM
Bioorg Med Chem Lett; 2007 May; 17(9):2643-8. PubMed ID: 17314044
[TBL] [Abstract][Full Text] [Related]
19. 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.
Chłoń-Rzepa G; Zmudzki P; Zajdel P; Bojarski AJ; Duszyńska B; Nikiforuk A; Tatarczyńska E; Pawłowski M
Bioorg Med Chem; 2007 Aug; 15(15):5239-50. PubMed ID: 17517514
[TBL] [Abstract][Full Text] [Related]
20. 1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.
Dowd CS; Herrick-Davis K; Egan C; DuPre A; Smith C; Teitler M; Glennon RA
J Med Chem; 2000 Aug; 43(16):3074-84. PubMed ID: 10956215
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
