485 related articles for article (PubMed ID: 12065438)
1. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
Luo G; Cunningham M; Kim S; Burn T; Lin J; Sinz M; Hamilton G; Rizzo C; Jolley S; Gilbert D; Downey A; Mudra D; Graham R; Carroll K; Xie J; Madan A; Parkinson A; Christ D; Selling B; LeCluyse E; Gan LS
Drug Metab Dispos; 2002 Jul; 30(7):795-804. PubMed ID: 12065438
[TBL] [Abstract][Full Text] [Related]
2. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.
Faucette SR; Wang H; Hamilton GA; Jolley SL; Gilbert D; Lindley C; Yan B; Negishi M; LeCluyse EL
Drug Metab Dispos; 2004 Mar; 32(3):348-58. PubMed ID: 14977870
[TBL] [Abstract][Full Text] [Related]
3. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.
Sahi J; Shord SS; Lindley C; Ferguson S; LeCluyse EL
J Biochem Mol Toxicol; 2009; 23(1):43-58. PubMed ID: 19202563
[TBL] [Abstract][Full Text] [Related]
4. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
[TBL] [Abstract][Full Text] [Related]
5. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Li T; Chiang JY
Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
[TBL] [Abstract][Full Text] [Related]
6. Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes.
Prueksaritanont T; Richards KM; Qiu Y; Strong-Basalyga K; Miller A; Li C; Eisenhandler R; Carlini EJ
Pharm Res; 2005 Jan; 22(1):71-8. PubMed ID: 15771232
[TBL] [Abstract][Full Text] [Related]
7. Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes.
Nallani SC; Goodwin B; Buckley AR; Buckley DJ; Desai PB
Cancer Chemother Pharmacol; 2004 Sep; 54(3):219-29. PubMed ID: 15175893
[TBL] [Abstract][Full Text] [Related]
8. Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells.
McGinnity DF; Zhang G; Kenny JR; Hamilton GA; Otmani S; Stams KR; Haney S; Brassil P; Stresser DM; Riley RJ
Drug Metab Dispos; 2009 Jun; 37(6):1259-68. PubMed ID: 19307295
[TBL] [Abstract][Full Text] [Related]
9. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
El-Sankary W; Bombail V; Gibson GG; Plant N
Drug Metab Dispos; 2002 Sep; 30(9):1029-34. PubMed ID: 12167569
[TBL] [Abstract][Full Text] [Related]
10. Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.
Moscovitz JE; Lin Z; Johnson N; Tu M; Goosen TC; Weng Y; Kalgutkar AS
Xenobiotica; 2018 Jul; 48(7):647-655. PubMed ID: 28685622
[TBL] [Abstract][Full Text] [Related]
11. Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers.
Cui X; Thomas A; Gerlach V; White RE; Morrison RA; Cheng KC
Biochem Pharmacol; 2008 Sep; 76(5):680-9. PubMed ID: 18647599
[TBL] [Abstract][Full Text] [Related]
12. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
Pascussi JM; Drocourt L; Fabre JM; Maurel P; Vilarem MJ
Mol Pharmacol; 2000 Aug; 58(2):361-72. PubMed ID: 10908304
[TBL] [Abstract][Full Text] [Related]
13. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Kim S; Dinchuk JE; Anthony MN; Orcutt T; Zoeckler ME; Sauer MB; Mosure KW; Vuppugalla R; Grace JE; Simmermacher J; Dulac HA; Pizzano J; Sinz M
Drug Metab Dispos; 2010 Jan; 38(1):16-24. PubMed ID: 19833845
[TBL] [Abstract][Full Text] [Related]
14. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.
Drocourt L; Pascussi JM; Assenat E; Fabre JM; Maurel P; Vilarem MJ
Drug Metab Dispos; 2001 Oct; 29(10):1325-31. PubMed ID: 11560876
[TBL] [Abstract][Full Text] [Related]
15. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
Rhodes SP; Otten JN; Hingorani GP; Hartley DP; Franklin RB
J Pharmacol Toxicol Methods; 2011; 63(3):223-6. PubMed ID: 21111054
[TBL] [Abstract][Full Text] [Related]
16. A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides.
Lemaire G; de Sousa G; Rahmani R
Biochem Pharmacol; 2004 Dec; 68(12):2347-58. PubMed ID: 15548381
[TBL] [Abstract][Full Text] [Related]
17. Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor.
Schmiedlin-Ren P; Thummel KE; Fisher JM; Paine MF; Watkins PB
Drug Metab Dispos; 2001 Nov; 29(11):1446-53. PubMed ID: 11602520
[TBL] [Abstract][Full Text] [Related]
18. Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate.
Nallani SC; Glauser TA; Hariparsad N; Setchell K; Buckley DJ; Buckley AR; Desai PB
Epilepsia; 2003 Dec; 44(12):1521-8. PubMed ID: 14636322
[TBL] [Abstract][Full Text] [Related]
19. Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor.
Yang J; Yan B
Toxicol Sci; 2007 Jan; 95(1):13-22. PubMed ID: 17003103
[TBL] [Abstract][Full Text] [Related]
20. A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction.
Vignati LA; Bogni A; Grossi P; Monshouwer M
Toxicology; 2004 Jun; 199(1):23-33. PubMed ID: 15125996
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
