BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

462 related articles for article (PubMed ID: 12077343)

  • 1. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
    Rheinwald JG; Hahn WC; Ramsey MR; Wu JY; Guo Z; Tsao H; De Luca M; CatricalĂ  C; O'Toole KM
    Mol Cell Biol; 2002 Jul; 22(14):5157-72. PubMed ID: 12077343
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
    Dickson MA; Hahn WC; Ino Y; Ronfard V; Wu JY; Weinberg RA; Louis DN; Li FP; Rheinwald JG
    Mol Cell Biol; 2000 Feb; 20(4):1436-47. PubMed ID: 10648628
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells.
    Darbro BW; Lee KM; Nguyen NK; Domann FE; Klingelhutz AJ
    Oncogene; 2006 Nov; 25(56):7421-33. PubMed ID: 16767161
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
    Haga K; Ohno S; Yugawa T; Narisawa-Saito M; Fujita M; Sakamoto M; Galloway DA; Kiyono T
    Cancer Sci; 2007 Feb; 98(2):147-54. PubMed ID: 17233832
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Low p16
    Graham MK; Principessa L; Antony L; Meeker AK; Isaacs JT
    Prostate; 2017 Mar; 77(4):374-384. PubMed ID: 27859428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16(INK4a.).
    Sasaki M; Kajiya H; Ozeki S; Okabe K; Ikebe T
    Biochem Biophys Res Commun; 2014 Sep; 452(3):622-8. PubMed ID: 25181340
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
    Dabelsteen S; Hercule P; Barron P; Rice M; Dorsainville G; Rheinwald JG
    Stem Cells; 2009 Jun; 27(6):1388-99. PubMed ID: 19489101
    [TBL] [Abstract][Full Text] [Related]  

  • 8. CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
    Ruas M; Gregory F; Jones R; Poolman R; Starborg M; Rowe J; Brookes S; Peters G
    Mol Cell Biol; 2007 Jun; 27(12):4273-82. PubMed ID: 17420273
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Senescence research from historical theory to future clinical application.
    Kameda M; Mikawa T; Yokode M; Inagaki N; Kondoh H
    Geriatr Gerontol Int; 2021 Feb; 21(2):125-130. PubMed ID: 33372374
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.
    Ohashi S; Natsuizaka M; Wong GS; Michaylira CZ; Grugan KD; Stairs DB; Kalabis J; Vega ME; Kalman RA; Nakagawa M; Klein-Szanto AJ; Herlyn M; Diehl JA; Rustgi AK; Nakagawa H
    Cancer Res; 2010 May; 70(10):4174-84. PubMed ID: 20424117
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells.
    Yasaei H; Gilham E; Pickles JC; Roberts TP; O'Donovan M; Newbold RF
    Oncogene; 2013 Jan; 32(2):171-9. PubMed ID: 22410783
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
    Burnworth B; Arendt S; Muffler S; Steinkraus V; Bröcker EB; Birek C; Hartschuh W; Jauch A; Boukamp P
    Eur J Cell Biol; 2007 Dec; 86(11-12):763-80. PubMed ID: 17198740
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes.
    Darbro BW; Schneider GB; Klingelhutz AJ
    J Invest Dermatol; 2005 Sep; 125(3):499-509. PubMed ID: 16117791
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.
    Zhang D; Sun X; Liu J; Xie X; Cui W; Zhu Y
    Arterioscler Thromb Vasc Biol; 2015 Jan; 35(1):71-8. PubMed ID: 25359865
    [TBL] [Abstract][Full Text] [Related]  

  • 15. p16INK4a-induced senescence is disabled by melanoma-associated mutations.
    Haferkamp S; Becker TM; Scurr LL; Kefford RF; Rizos H
    Aging Cell; 2008 Oct; 7(5):733-45. PubMed ID: 18843795
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.
    Brookes S; Gagrica S; Sanij E; Rowe J; Gregory FJ; Hara E; Peters G
    Cell Cycle; 2015; 14(8):1164-73. PubMed ID: 25695870
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence.
    Natarajan E; Omobono JD; Guo Z; Hopkinson S; Lazar AJ; Brenn T; Jones JC; Rheinwald JG
    Am J Pathol; 2006 Jun; 168(6):1821-37. PubMed ID: 16723698
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.
    Haferkamp S; Tran SL; Becker TM; Scurr LL; Kefford RF; Rizos H
    Aging (Albany NY); 2009 May; 1(6):542-56. PubMed ID: 20157537
    [TBL] [Abstract][Full Text] [Related]  

  • 19. p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses.
    Wang Y; Sharpless N; Chang S
    J Clin Invest; 2013 Oct; 123(10):4489-501. PubMed ID: 24091330
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Immortalization of bovine mammary epithelial cells alone by human telomerase reverse transcriptase.
    Zhao CF; Hu HY; Meng L; Li QQ; Lin AX
    Cell Biol Int; 2010 Apr; 34(6):579-86. PubMed ID: 20175753
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.