226 related articles for article (PubMed ID: 12084452)
1. Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents.
Schramm VL
Biochim Biophys Acta; 2002 Jul; 1587(2-3):107-17. PubMed ID: 12084452
[TBL] [Abstract][Full Text] [Related]
2. Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.
Kicska GA; Long L; Hörig H; Fairchild C; Tyler PC; Furneaux RH; Schramm VL; Kaufman HL
Proc Natl Acad Sci U S A; 2001 Apr; 98(8):4593-8. PubMed ID: 11287638
[TBL] [Abstract][Full Text] [Related]
3. Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.
Kicska GA; Tyler PC; Evans GB; Furneaux RH; Schramm VL; Kim K
J Biol Chem; 2002 Feb; 277(5):3226-31. PubMed ID: 11706018
[TBL] [Abstract][Full Text] [Related]
4. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent.
Bantia S; Miller PJ; Parker CD; Ananth SL; Horn LL; Kilpatrick JM; Morris PE; Hutchison TL; Montgomery JA; Sandhu JS
Int Immunopharmacol; 2001 Jun; 1(6):1199-210. PubMed ID: 11407314
[TBL] [Abstract][Full Text] [Related]
5. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.
Miles RW; Tyler PC; Furneaux RH; Bagdassarian CK; Schramm VL
Biochemistry; 1998 Jun; 37(24):8615-21. PubMed ID: 9628722
[TBL] [Abstract][Full Text] [Related]
6. A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
Gandhi V; Kilpatrick JM; Plunkett W; Ayres M; Harman L; Du M; Bantia S; Davisson J; Wierda WG; Faderl S; Kantarjian H; Thomas D
Blood; 2005 Dec; 106(13):4253-60. PubMed ID: 16131572
[TBL] [Abstract][Full Text] [Related]
7. Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.
Lewandowicz A; Ringia EA; Ting LM; Kim K; Tyler PC; Evans GB; Zubkova OV; Mee S; Painter GF; Lenz DH; Furneaux RH; Schramm VL
J Biol Chem; 2005 Aug; 280(34):30320-8. PubMed ID: 15961383
[TBL] [Abstract][Full Text] [Related]
8. Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma.
Ravandi F; Gandhi V
Expert Opin Investig Drugs; 2006 Dec; 15(12):1601-13. PubMed ID: 17107284
[TBL] [Abstract][Full Text] [Related]
9. Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.
Balakrishnan K; Nimmanapalli R; Ravandi F; Keating MJ; Gandhi V
Blood; 2006 Oct; 108(7):2392-8. PubMed ID: 16778146
[TBL] [Abstract][Full Text] [Related]
10. Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.
Kicska GA; Tyler PC; Evans GB; Furneaux RH; Shi W; Fedorov A; Lewandowicz A; Cahill SM; Almo SC; Schramm VL
Biochemistry; 2002 Dec; 41(49):14489-98. PubMed ID: 12463747
[TBL] [Abstract][Full Text] [Related]
11. Structural basis for inhibition of human PNP by immucillin-H.
Filgueira de Azevedo W; Canduri F; Marangoni dos Santos D; Pereira JH; Dias MV; Silva RG; Mendes MA; Basso LA; Palma MS; Santos DS
Biochem Biophys Res Commun; 2003 Oct; 309(4):917-22. PubMed ID: 13679061
[TBL] [Abstract][Full Text] [Related]
12. Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.
Evans GB; Furneaux RH; Lewandowicz A; Schramm VL; Tyler PC
J Med Chem; 2003 Jul; 46(15):3412-23. PubMed ID: 12852771
[TBL] [Abstract][Full Text] [Related]
13. Pharmacology and mechanism of action of forodesine, a T-cell targeted agent.
Gandhi V; Balakrishnan K
Semin Oncol; 2007 Dec; 34(6 Suppl 5):S8-12. PubMed ID: 18086347
[TBL] [Abstract][Full Text] [Related]
14. Forodesine (BCX-1777, Immucillin H)--a new purine nucleoside analogue: mechanism of action and potential clinical application.
Korycka A; Błoński JZ; Robak T
Mini Rev Med Chem; 2007 Sep; 7(9):976-83. PubMed ID: 17897085
[TBL] [Abstract][Full Text] [Related]
15. [Tight binding transition state analogues of purine nucleoside phosphorylase--meaning, design and properties].
Lewandowicz A
Postepy Biochem; 2004; 50(3):218-27. PubMed ID: 15822751
[No Abstract] [Full Text] [Related]
16. The transition state analog inhibitor of Purine Nucleoside Phosphorylase (PNP) Immucillin-H arrests bone loss in rat periodontal disease models.
Deves C; de Assunção TM; Ducati RG; Campos MM; Basso LA; Santos DS; Batista EL
Bone; 2013 Jan; 52(1):167-75. PubMed ID: 23026564
[TBL] [Abstract][Full Text] [Related]
17. Transition states and inhibitors of the purine nucleoside phosphorylase family.
Taylor Ringia EA; Schramm VL
Curr Top Med Chem; 2005; 5(13):1237-58. PubMed ID: 16305529
[TBL] [Abstract][Full Text] [Related]
18. New catalytic mechanism for human purine nucleoside phosphorylase.
Canduri F; Fadel V; Basso LA; Palma MS; Santos DS; de Azevedo WF
Biochem Biophys Res Commun; 2005 Feb; 327(3):646-9. PubMed ID: 15649395
[TBL] [Abstract][Full Text] [Related]
19. Purine nucleoside phosphorylase inhibitors in T-cell malignancies.
Bantia S; Kilpatrick JM
Curr Opin Drug Discov Devel; 2004 Mar; 7(2):243-7. PubMed ID: 15603259
[TBL] [Abstract][Full Text] [Related]
20. Intracellular rebinding of transition-state analogues provides extended
Gebre ST; Cameron SA; Li L; Babu YS; Schramm VL
J Biol Chem; 2017 Sep; 292(38):15907-15915. PubMed ID: 28794158
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]