BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

226 related articles for article (PubMed ID: 12084452)

  • 1. Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents.
    Schramm VL
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):107-17. PubMed ID: 12084452
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.
    Kicska GA; Long L; Hörig H; Fairchild C; Tyler PC; Furneaux RH; Schramm VL; Kaufman HL
    Proc Natl Acad Sci U S A; 2001 Apr; 98(8):4593-8. PubMed ID: 11287638
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.
    Kicska GA; Tyler PC; Evans GB; Furneaux RH; Schramm VL; Kim K
    J Biol Chem; 2002 Feb; 277(5):3226-31. PubMed ID: 11706018
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent.
    Bantia S; Miller PJ; Parker CD; Ananth SL; Horn LL; Kilpatrick JM; Morris PE; Hutchison TL; Montgomery JA; Sandhu JS
    Int Immunopharmacol; 2001 Jun; 1(6):1199-210. PubMed ID: 11407314
    [TBL] [Abstract][Full Text] [Related]  

  • 5. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.
    Miles RW; Tyler PC; Furneaux RH; Bagdassarian CK; Schramm VL
    Biochemistry; 1998 Jun; 37(24):8615-21. PubMed ID: 9628722
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
    Gandhi V; Kilpatrick JM; Plunkett W; Ayres M; Harman L; Du M; Bantia S; Davisson J; Wierda WG; Faderl S; Kantarjian H; Thomas D
    Blood; 2005 Dec; 106(13):4253-60. PubMed ID: 16131572
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.
    Lewandowicz A; Ringia EA; Ting LM; Kim K; Tyler PC; Evans GB; Zubkova OV; Mee S; Painter GF; Lenz DH; Furneaux RH; Schramm VL
    J Biol Chem; 2005 Aug; 280(34):30320-8. PubMed ID: 15961383
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma.
    Ravandi F; Gandhi V
    Expert Opin Investig Drugs; 2006 Dec; 15(12):1601-13. PubMed ID: 17107284
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.
    Balakrishnan K; Nimmanapalli R; Ravandi F; Keating MJ; Gandhi V
    Blood; 2006 Oct; 108(7):2392-8. PubMed ID: 16778146
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.
    Kicska GA; Tyler PC; Evans GB; Furneaux RH; Shi W; Fedorov A; Lewandowicz A; Cahill SM; Almo SC; Schramm VL
    Biochemistry; 2002 Dec; 41(49):14489-98. PubMed ID: 12463747
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural basis for inhibition of human PNP by immucillin-H.
    Filgueira de Azevedo W; Canduri F; Marangoni dos Santos D; Pereira JH; Dias MV; Silva RG; Mendes MA; Basso LA; Palma MS; Santos DS
    Biochem Biophys Res Commun; 2003 Oct; 309(4):917-22. PubMed ID: 13679061
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.
    Evans GB; Furneaux RH; Lewandowicz A; Schramm VL; Tyler PC
    J Med Chem; 2003 Jul; 46(15):3412-23. PubMed ID: 12852771
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacology and mechanism of action of forodesine, a T-cell targeted agent.
    Gandhi V; Balakrishnan K
    Semin Oncol; 2007 Dec; 34(6 Suppl 5):S8-12. PubMed ID: 18086347
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Forodesine (BCX-1777, Immucillin H)--a new purine nucleoside analogue: mechanism of action and potential clinical application.
    Korycka A; Błoński JZ; Robak T
    Mini Rev Med Chem; 2007 Sep; 7(9):976-83. PubMed ID: 17897085
    [TBL] [Abstract][Full Text] [Related]  

  • 15. [Tight binding transition state analogues of purine nucleoside phosphorylase--meaning, design and properties].
    Lewandowicz A
    Postepy Biochem; 2004; 50(3):218-27. PubMed ID: 15822751
    [No Abstract]   [Full Text] [Related]  

  • 16. The transition state analog inhibitor of Purine Nucleoside Phosphorylase (PNP) Immucillin-H arrests bone loss in rat periodontal disease models.
    Deves C; de Assunção TM; Ducati RG; Campos MM; Basso LA; Santos DS; Batista EL
    Bone; 2013 Jan; 52(1):167-75. PubMed ID: 23026564
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Transition states and inhibitors of the purine nucleoside phosphorylase family.
    Taylor Ringia EA; Schramm VL
    Curr Top Med Chem; 2005; 5(13):1237-58. PubMed ID: 16305529
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New catalytic mechanism for human purine nucleoside phosphorylase.
    Canduri F; Fadel V; Basso LA; Palma MS; Santos DS; de Azevedo WF
    Biochem Biophys Res Commun; 2005 Feb; 327(3):646-9. PubMed ID: 15649395
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Purine nucleoside phosphorylase inhibitors in T-cell malignancies.
    Bantia S; Kilpatrick JM
    Curr Opin Drug Discov Devel; 2004 Mar; 7(2):243-7. PubMed ID: 15603259
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intracellular rebinding of transition-state analogues provides extended
    Gebre ST; Cameron SA; Li L; Babu YS; Schramm VL
    J Biol Chem; 2017 Sep; 292(38):15907-15915. PubMed ID: 28794158
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.