222 related articles for article (PubMed ID: 12086480)
1. Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.
Matter H; Kotsonis P; Klingler O; Strobel H; Fröhlich LG; Frey A; Pfleiderer W; Schmidt HH
J Med Chem; 2002 Jul; 45(14):2923-41. PubMed ID: 12086480
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: structure-activity relationship of antagonists of (6R)-5,6,7,8-tetrahydrobiopterin cofactor.
Fröhlich LG; Kotsonis P; Traub H; Taghavi-Moghadam S; Al-Masoudi N; Hofmann H; Strobel H; Matter H; Pfleiderer W; Schmidt HH
J Med Chem; 1999 Oct; 42(20):4108-21. PubMed ID: 10514281
[TBL] [Abstract][Full Text] [Related]
3. Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
Matter H; Kotsonis P
Med Res Rev; 2004 Sep; 24(5):662-84. PubMed ID: 15224385
[TBL] [Abstract][Full Text] [Related]
4. Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
Matter H; Kumar HS; Fedorov R; Frey A; Kotsonis P; Hartmann E; Fröhlich LG; Reif A; Pfleiderer W; Scheurer P; Ghosh DK; Schlichting I; Schmidt HH
J Med Chem; 2005 Jul; 48(15):4783-92. PubMed ID: 16033258
[TBL] [Abstract][Full Text] [Related]
5. Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin.
Kotsonis P; Fröhlich LG; Raman CS; Li H; Berg M; Gerwig R; Groehn V; Kang Y; Al-Masoudi N; Taghavi-Moghadam S; Mohr D; Münch U; Schnabel J; Martásek P; Masters BS; Strobel H; Poulos T; Matter H; Pfleiderer W; Schmidt HH
J Biol Chem; 2001 Dec; 276(52):49133-41. PubMed ID: 11590164
[TBL] [Abstract][Full Text] [Related]
6. Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.
Kotsonis P; Fröhlich LG; Shutenko ZV; Horejsi R; Pfleiderer W; Schmidt HH
Biochem J; 2000 Mar; 346 Pt 3(Pt 3):767-76. PubMed ID: 10698705
[TBL] [Abstract][Full Text] [Related]
7. Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase.
Reif A; Fröhlich LG; Kotsonis P; Frey A; Bömmel HM; Wink DA; Pfleiderer W; Schmidt HH
J Biol Chem; 1999 Aug; 274(35):24921-9. PubMed ID: 10455167
[TBL] [Abstract][Full Text] [Related]
8. Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.
Matter H; Defossa E; Heinelt U; Blohm PM; Schneider D; Müller A; Herok S; Schreuder H; Liesum A; Brachvogel V; Lönze P; Walser A; Al-Obeidi F; Wildgoose P
J Med Chem; 2002 Jun; 45(13):2749-69. PubMed ID: 12061878
[TBL] [Abstract][Full Text] [Related]
9. Structure-function studies on nitric oxide synthases.
Li H; Poulos TL
J Inorg Biochem; 2005 Jan; 99(1):293-305. PubMed ID: 15598508
[TBL] [Abstract][Full Text] [Related]
10. A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Wang ZQ; Wei CC; Santolini J; Panda K; Wang Q; Stuehr DJ
Biochemistry; 2005 Mar; 44(12):4676-90. PubMed ID: 15779894
[TBL] [Abstract][Full Text] [Related]
11. Nitric oxide synthases: structure, function and inhibition.
Alderton WK; Cooper CE; Knowles RG
Biochem J; 2001 Aug; 357(Pt 3):593-615. PubMed ID: 11463332
[TBL] [Abstract][Full Text] [Related]
12. Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
Flinspach M; Li H; Jamal J; Yang W; Huang H; Silverman RB; Poulos TL
Biochemistry; 2004 May; 43(18):5181-7. PubMed ID: 15122883
[TBL] [Abstract][Full Text] [Related]
13. Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design.
Fedorov R; Vasan R; Ghosh DK; Schlichting I
Proc Natl Acad Sci U S A; 2004 Apr; 101(16):5892-7. PubMed ID: 15071192
[TBL] [Abstract][Full Text] [Related]
14. Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.
Li H; Raman CS; Martásek P; Masters BS; Poulos TL
Biochemistry; 2001 May; 40(18):5399-406. PubMed ID: 11331003
[TBL] [Abstract][Full Text] [Related]
15. Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis.
Matter H; Schwab W; Barbier D; Billen G; Haase B; Neises B; Schudok M; Thorwart W; Schreuder H; Brachvogel V; Lönze P; Weithmann KU
J Med Chem; 1999 Jun; 42(11):1908-20. PubMed ID: 10354399
[TBL] [Abstract][Full Text] [Related]
16. Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions.
Paige JS; Jaffrey SR
Curr Top Med Chem; 2007; 7(1):97-114. PubMed ID: 17266598
[TBL] [Abstract][Full Text] [Related]
17. QSAR Studies of Nitric Oxide Synthase Inhibitors.
Tsopka IC; Hadjipavlou-Litina D
Curr Top Med Chem; 2023; 23(29):2723-2734. PubMed ID: 38093588
[TBL] [Abstract][Full Text] [Related]
18. 3D QSAR studies on protein tyrosine phosphatase 1B inhibitors: comparison of the quality and predictivity among 3D QSAR models obtained from different conformer-based alignments.
Pandey G; Saxena AK
J Chem Inf Model; 2006; 46(6):2579-90. PubMed ID: 17125198
[TBL] [Abstract][Full Text] [Related]
19. Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin.
Gorren AC; Schrammel A; Riethmüller C; Schmidt K; Koesling D; Werner ER; Mayer B
Biochem J; 2000 Apr; 347(Pt 2):475-84. PubMed ID: 10749677
[TBL] [Abstract][Full Text] [Related]
20. Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.
Sun G; Fan T; Zhang N; Ren T; Zhao L; Zhong R
Molecules; 2016 Jun; 21(7):. PubMed ID: 27347909
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]