BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

250 related articles for article (PubMed ID: 12093355)

  • 1. Are chemically reactive metabolites responsible for adverse reactions to drugs?
    Williams DP; Kitteringham NR; Naisbitt DJ; Pirmohamed M; Smith DA; Park BK
    Curr Drug Metab; 2002 Aug; 3(4):351-66. PubMed ID: 12093355
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Selection of new chemical entities with decreased potential for adverse drug reactions.
    Park KB; Dalton-Brown E; Hirst C; Williams DP
    Eur J Pharmacol; 2006 Nov; 549(1-3):1-8. PubMed ID: 16979156
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolic activation in drug-induced liver injury.
    Leung L; Kalgutkar AS; Obach RS
    Drug Metab Rev; 2012 Feb; 44(1):18-33. PubMed ID: 21939431
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Toxicophores: investigations in drug safety.
    Williams DP
    Toxicology; 2006 Sep; 226(1):1-11. PubMed ID: 16860917
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multi-organ disease secondary to sulfonamide toxicity.
    Pickert CB; Belsha CW; Kearns GL
    Pediatrics; 1994 Aug; 94(2 Pt 1):237-9. PubMed ID: 8036081
    [No Abstract]   [Full Text] [Related]  

  • 6. [Hepatopathies and drugs].
    González Macias J; De Castro del Pozo S
    Rev Esp Enferm Apar Dig; 1974; 44(2):175-86. PubMed ID: 4418081
    [No Abstract]   [Full Text] [Related]  

  • 7. [Reactive metabolites of xenobiotics : their role in the hepatotoxicity of drugs].
    Pessayre D; Benhamou JP
    C R Seances Soc Biol Fil; 1979; 173(2):458-68. PubMed ID: 159767
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective.
    Tang W; Lu AY
    Drug Metab Rev; 2010 May; 42(2):225-49. PubMed ID: 19939207
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Idiosyncratic toxicity: the role of toxicophores and bioactivation.
    Williams DP; Park BK
    Drug Discov Today; 2003 Nov; 8(22):1044-50. PubMed ID: 14690635
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science.
    Antoine DJ; Williams DP; Park BK
    Expert Opin Drug Metab Toxicol; 2008 Nov; 4(11):1415-27. PubMed ID: 18950283
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bioactivation of drugs: risk and drug design.
    Walsh JS; Miwa GT
    Annu Rev Pharmacol Toxicol; 2011; 51():145-67. PubMed ID: 21210745
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of reactive metabolites in drug-induced hepatotoxicity.
    Srivastava A; Maggs JL; Antoine DJ; Williams DP; Smith DA; Park BK
    Handb Exp Pharmacol; 2010; (196):165-94. PubMed ID: 20020263
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Predicting toxicities of reactive metabolite-positive drug candidates.
    Kalgutkar AS; Dalvie D
    Annu Rev Pharmacol Toxicol; 2015; 55():35-54. PubMed ID: 25292426
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Role of metabolism in drug-induced idiosyncratic hepatotoxicity.
    Walgren JL; Mitchell MD; Thompson DC
    Crit Rev Toxicol; 2005; 35(4):325-61. PubMed ID: 15989140
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Drug-induced hepatotoxicity.
    Lee WM
    N Engl J Med; 1995 Oct; 333(17):1118-27. PubMed ID: 7565951
    [No Abstract]   [Full Text] [Related]  

  • 16. Extrahepatic targets and cellular reactivity of drug metabolites.
    Orhan H
    Curr Med Chem; 2015; 22(4):408-37. PubMed ID: 25174932
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In vitro evaluation of potential hepatotoxicity induced by drugs.
    Gómez-Lechón MJ; Lahoz A; Gombau L; Castell JV; Donato MT
    Curr Pharm Des; 2010 Jun; 16(17):1963-77. PubMed ID: 20236064
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.
    Thompson RA; Isin EM; Ogese MO; Mettetal JT; Williams DP
    Chem Res Toxicol; 2016 Apr; 29(4):505-33. PubMed ID: 26735163
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Drugs and the liver.
    Reidenberg MM; Breckenridge A
    Clin Pharmacol Ther; 1998 Oct; 64(4):353-4. PubMed ID: 9797790
    [No Abstract]   [Full Text] [Related]  

  • 20. Cytochromes P450 in the bioactivation of chemicals.
    Ioannides C; Lewis DF
    Curr Top Med Chem; 2004; 4(16):1767-88. PubMed ID: 15579107
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.