BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 12110684)

  • 1. Mutations in the nucleotide binding domain 1 signature motif region rescue processing and functional defects of cystic fibrosis transmembrane conductance regulator delta f508.
    DeCarvalho AC; Gansheroff LJ; Teem JL
    J Biol Chem; 2002 Sep; 277(39):35896-905. PubMed ID: 12110684
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR[delta]F508.
    deCarvalho AC; Ndi CP; Tsopmo A; Tane P; Ayafor J; Connolly JD; Teem JL
    Mol Med; 2002 Feb; 8(2):75-87. PubMed ID: 12080183
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of revertants for the cystic fibrosis delta F508 mutation using STE6-CFTR chimeras in yeast.
    Teem JL; Berger HA; Ostedgaard LS; Rich DP; Tsui LC; Welsh MJ
    Cell; 1993 Apr; 73(2):335-46. PubMed ID: 7682896
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain.
    Hoelen H; Kleizen B; Schmidt A; Richardson J; Charitou P; Thomas PJ; Braakman I
    PLoS One; 2010 Nov; 5(11):e15458. PubMed ID: 21152102
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels.
    Wang F; Zeltwanger S; Hu S; Hwang TC
    J Physiol; 2000 May; 524 Pt 3(Pt 3):637-48. PubMed ID: 10790148
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms.
    Roxo-Rosa M; Xu Z; Schmidt A; Neto M; Cai Z; Soares CM; Sheppard DN; Amaral MD
    Proc Natl Acad Sci U S A; 2006 Nov; 103(47):17891-6. PubMed ID: 17098864
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substitution of Yor1p NBD1 residues improves the thermal stability of Human Cystic Fibrosis Transmembrane Conductance Regulator.
    Xavier BM; Hildebrandt E; Jiang F; Ding H; Kappes JC; Urbatsch IL
    Protein Eng Des Sel; 2017 Oct; 30(10):729-741. PubMed ID: 29053845
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.
    Wei S; Roessler BC; Chauvet S; Guo J; Hartman JL; Kirk KL
    J Biol Chem; 2014 Jul; 289(29):19942-57. PubMed ID: 24876383
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.
    Melin P; Thoreau V; Norez C; Bilan F; Kitzis A; Becq F
    Biochem Pharmacol; 2004 Jun; 67(12):2187-96. PubMed ID: 15163550
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutation of R555 in CFTR-delta F508 enhances function and partially corrects defective processing.
    Teem JL; Carson MR; Welsh MJ
    Recept Channels; 1996; 4(1):63-72. PubMed ID: 8723647
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia.
    Dong Q; Ernst SE; Ostedgaard LS; Shah VS; Ver Heul AR; Welsh MJ; Randak CO
    J Biol Chem; 2015 May; 290(22):14140-53. PubMed ID: 25887396
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers.
    Bebok Z; Collawn JF; Wakefield J; Parker W; Li Y; Varga K; Sorscher EJ; Clancy JP
    J Physiol; 2005 Dec; 569(Pt 2):601-15. PubMed ID: 16210354
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B.
    Melin P; Norez C; Callebaut I; Becq F
    J Membr Biol; 2005 Dec; 208(3):203-12. PubMed ID: 16604470
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.
    Treharne KJ; Xu Z; Chen JH; Best OG; Cassidy DM; Gruenert DC; Hegyi P; Gray MA; Sheppard DN; Kunzelmann K; Mehta A
    Cell Physiol Biochem; 2009; 24(5-6):347-60. PubMed ID: 19910675
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR.
    Jih KY; Li M; Hwang TC; Bompadre SG
    J Physiol; 2011 Jun; 589(Pt 11):2719-31. PubMed ID: 21486785
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.
    Veit G; Oliver K; Apaja PM; Perdomo D; Bidaud-Meynard A; Lin ST; Guo J; Icyuz M; Sorscher EJ; Hartman JL; Lukacs GL
    PLoS Biol; 2016 May; 14(5):e1002462. PubMed ID: 27168400
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
    Hall JD; Wang H; Byrnes LJ; Shanker S; Wang K; Efremov IV; Chong PA; Forman-Kay JD; Aulabaugh AE
    Protein Sci; 2016 Feb; 25(2):360-73. PubMed ID: 26444971
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analysis of the localization of STE6/CFTR chimeras in a Saccharomyces cerevisiae model for the cystic fibrosis defect CFTR delta F508.
    Paddon C; Loayza D; Vangelista L; Solari R; Michaelis S
    Mol Microbiol; 1996 Mar; 19(5):1007-17. PubMed ID: 8830258
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.
    Yang H; Shelat AA; Guy RK; Gopinath VS; Ma T; Du K; Lukacs GL; Taddei A; Folli C; Pedemonte N; Galietta LJ; Verkman AS
    J Biol Chem; 2003 Sep; 278(37):35079-85. PubMed ID: 12832418
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect.
    Dong Q; Ostedgaard LS; Rogers C; Vermeer DW; Zhang Y; Welsh MJ
    Proc Natl Acad Sci U S A; 2012 Jan; 109(3):917-22. PubMed ID: 22210114
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.