BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 12113812)

  • 1. Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents.
    Kamal A; Reddy BS; Reddy GS; Ramesh G
    Bioorg Med Chem Lett; 2002 Aug; 12(15):1933-5. PubMed ID: 12113812
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity.
    Kamal A; Ramu R; Khanna GB; Saxena AK; Shanmugavel M; Pandita RM
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4907-9. PubMed ID: 15341949
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.
    Kamal A; Shankaraiah N; Prabhakar S; Reddy ChR; Markandeya N; Reddy KL; Devaiah V
    Bioorg Med Chem Lett; 2008 Apr; 18(7):2434-9. PubMed ID: 18325766
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c]benzodiazepine hybrids.
    Kamal A; Ramesh G; Srinivas O; Ramulu P
    Bioorg Med Chem Lett; 2004 Jan; 14(2):471-4. PubMed ID: 14698184
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Kamal A; Srinivas O; Ramulu P; Ramesh G; Kumar PP; Kumar MS
    Bioorg Med Chem; 2004 Aug; 12(16):4337-50. PubMed ID: 15265486
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability.
    Kamal A; Reddy MK; Ramaiah MJ; Srikanth YV; Rajender ; Reddy VS; Kumar GB; Pushpavalli SN; Bag I; Juvekar A; Sen S; Zingde SM; Pal-Bhadra M
    ChemMedChem; 2011 Sep; 6(9):1665-79. PubMed ID: 21732540
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
    Kamal A; Khan MN; Reddy KS; Ahmed SK; Kumar MS; Juvekar A; Sen S; Zingde S
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5345-8. PubMed ID: 17723301
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of novel C2 and C2-C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents.
    Kamal A; Srinivas O; Ramulu P; Ramesh G; Kumar PP
    Bioorg Med Chem Lett; 2003 Oct; 13(20):3577-81. PubMed ID: 14505674
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents.
    Wang JJ; Shen YK; Hu WP; Hsieh MC; Lin FL; Hsu MK; Hsu MH
    J Med Chem; 2006 Feb; 49(4):1442-9. PubMed ID: 16480280
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.
    Berry JM; Howard PW; Kelland LR; Thurston DE
    Bioorg Med Chem Lett; 2002 May; 12(10):1413-6. PubMed ID: 11992788
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
    Kamal A; Ramulu P; Srinivas O; Ramesh G; Kumar PP
    Bioorg Med Chem Lett; 2004 Sep; 14(18):4791-4. PubMed ID: 15324909
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.
    Donnell AF; Zhang Y; Stang EM; Wei DD; Tebben AJ; Perez HL; Schroeder GM; Pan C; Rao C; Borzilleri RM; Vite GD; Gangwar S
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5267-5271. PubMed ID: 29102228
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines as DNA-binding and potential anticancer agents.
    Kamal A; Rajender ; Reddy MK; Reddy VS; Kumar GB
    Med Chem; 2013 Mar; 9(2):177-92. PubMed ID: 22931493
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs).
    Corcoran DB; Lewis T; Nahar KS; Jamshidi S; Fegan C; Pepper C; Thurston DE; Rahman KM
    J Med Chem; 2019 Feb; 62(4):2127-2139. PubMed ID: 30688457
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
    Antonow D; Kaliszczak M; Kang GD; Coffils M; Tiberghien AC; Cooper N; Barata T; Heidelberger S; James CH; Zloh M; Jenkins TC; Reszka AP; Neidle S; Guichard SM; Jodrell DI; Hartley JA; Howard PW; Thurston DE
    J Med Chem; 2010 Apr; 53(7):2927-41. PubMed ID: 20218628
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.
    Baraldi PG; Cacciari B; Guiotto A; Leoni A; Romagnoli R; Spalluto G; Mongelli N; Howard PW; Thurston DE; Bianchi N; Gambari R
    Bioorg Med Chem Lett; 1998 Nov; 8(21):3019-24. PubMed ID: 9873668
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
    Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
    J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents.
    Kamal A; Ramesh G; Ramulu P; Srinivas O; Rehana T; Sheelu G
    Bioorg Med Chem Lett; 2003 Oct; 13(20):3451-4. PubMed ID: 14505647
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents.
    Kamal A; Laxman N; Ramesh G; Srinivas O; Ramulu P
    Bioorg Med Chem Lett; 2002 Aug; 12(15):1917-9. PubMed ID: 12113808
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity.
    Kamal A; Ramesh G; Srinivas O; Ramulu P; Laxman N; Rehana T; Deepak M; Achary MS; Nagarajaram HA
    Bioorg Med Chem; 2004 Oct; 12(20):5427-36. PubMed ID: 15388169
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.