257 related articles for article (PubMed ID: 12119000)
1. Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Chen Q; Ngui JS; Doss GA; Wang RW; Cai X; DiNinno FP; Blizzard TA; Hammond ML; Stearns RA; Evans DC; Baillie TA; Tang W
Chem Res Toxicol; 2002 Jul; 15(7):907-14. PubMed ID: 12119000
[TBL] [Abstract][Full Text] [Related]
2. Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation.
Baer BR; Wienkers LC; Rock DA
Chem Res Toxicol; 2007 Jun; 20(6):954-64. PubMed ID: 17497897
[TBL] [Abstract][Full Text] [Related]
3. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
[TBL] [Abstract][Full Text] [Related]
4. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
[TBL] [Abstract][Full Text] [Related]
5. Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates.
Pearson JT; Wahlstrom JL; Dickmann LJ; Kumar S; Halpert JR; Wienkers LC; Foti RS; Rock DA
Chem Res Toxicol; 2007 Dec; 20(12):1778-86. PubMed ID: 18001057
[TBL] [Abstract][Full Text] [Related]
6. In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.
Zhang Z; Chen Q; Li Y; Doss GA; Dean BJ; Ngui JS; Silva Elipe M; Kim S; Wu JY; Dininno F; Hammond ML; Stearns RA; Evans DC; Baillie TA; Tang W
Chem Res Toxicol; 2005 Apr; 18(4):675-85. PubMed ID: 15833027
[TBL] [Abstract][Full Text] [Related]
7. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
[TBL] [Abstract][Full Text] [Related]
8. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Liu H; Qin Z; Thatcher GR; Bolton JL
Chem Res Toxicol; 2007 Nov; 20(11):1676-84. PubMed ID: 17630709
[TBL] [Abstract][Full Text] [Related]
9. Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
Wen B; Chen Y; Fitch WL
Drug Metab Dispos; 2009 Jul; 37(7):1557-62. PubMed ID: 19364830
[TBL] [Abstract][Full Text] [Related]
10. Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry.
Yukinaga H; Takami T; Shioyama SH; Tozuka Z; Masumoto H; Okazaki O; Sudo K
Chem Res Toxicol; 2007 Oct; 20(10):1373-8. PubMed ID: 17867646
[TBL] [Abstract][Full Text] [Related]
11. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
Tang C; Subramanian R; Kuo Y; Krymgold S; Lu P; Kuduk SD; Ng C; Feng DM; Elmore C; Soli E; Ho J; Bock MG; Baillie TA; Prueksaritanont T
Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
[TBL] [Abstract][Full Text] [Related]
12. Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib.
Amaya GM; Durandis R; Bourgeois DS; Perkins JA; Abouda AA; Wines KJ; Mohamud M; Starks SA; Daniels RN; Jackson KD
Chem Res Toxicol; 2018 Jul; 31(7):570-584. PubMed ID: 29847931
[TBL] [Abstract][Full Text] [Related]
13. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
He K; Talaat RE; Pool WF; Reily MD; Reed JE; Bridges AJ; Woolf TF
Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
[TBL] [Abstract][Full Text] [Related]
14. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.
Tang W; Stearns RA; Wang RW; Miller RR; Chen Q; Ngui J; Bakshi RK; Nargund RP; Dean DC; Baillie TA
Xenobiotica; 2008 Nov; 38(11):1437-51. PubMed ID: 18841517
[TBL] [Abstract][Full Text] [Related]
15. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
[TBL] [Abstract][Full Text] [Related]
16. In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct.
Stevens GJ; Hitchcock K; Wang YK; Coppola GM; Versace RW; Chin JA; Shapiro M; Suwanrumpha S; Mangold BL
Chem Res Toxicol; 1997 Jul; 10(7):733-41. PubMed ID: 9250406
[TBL] [Abstract][Full Text] [Related]
17. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
Shen S; Marchick MR; Davis MR; Doss GA; Pohl LR
Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
[TBL] [Abstract][Full Text] [Related]
18. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.
Gherezghiher TB; Michalsen B; Chandrasena RE; Qin Z; Sohn J; Thatcher GR; Bolton JL
Chem Biol Interact; 2012 Mar; 196(1-2):1-10. PubMed ID: 22290292
[TBL] [Abstract][Full Text] [Related]
19. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
Reilly CA; Ehlhardt WJ; Jackson DA; Kulanthaivel P; Mutlib AE; Espina RJ; Moody DE; Crouch DJ; Yost GS
Chem Res Toxicol; 2003 Mar; 16(3):336-49. PubMed ID: 12641434
[TBL] [Abstract][Full Text] [Related]
20. Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
Kassahun K; Skordos K; McIntosh I; Slaughter D; Doss GA; Baillie TA; Yost GS
Chem Res Toxicol; 2005 Sep; 18(9):1427-37. PubMed ID: 16167835
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]