BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

165 related articles for article (PubMed ID: 12123750)

  • 21. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.
    Stiborová M; Černá V; Moserová M; Mrízová I; Arlt VM; Frei E
    Int J Mol Sci; 2014 Dec; 16(1):284-306. PubMed ID: 25547492
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.
    Stiborová M; Rupertová M; Frei E
    Biochim Biophys Acta; 2011 Jan; 1814(1):175-85. PubMed ID: 20576524
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Ellipticines as DNA-targeted chemotherapeutics.
    Stiborová M; Frei E
    Curr Med Chem; 2014; 21(5):575-91. PubMed ID: 24059226
    [TBL] [Abstract][Full Text] [Related]  

  • 24. DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells.
    Poljaková J; Frei E; Gomez JE; Aimová D; Eckschlager T; Hrabeta J; Stiborová M
    Cancer Lett; 2007 Jul; 252(2):270-9. PubMed ID: 17306925
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.
    Indra R; Černá T; Heger Z; Hraběta J; Wilhelm M; Dostálová S; Lengálová A; Martínková M; Adam V; Eckschlager T; Schmeiser HH; Arlt VM; Stiborová M
    Toxicology; 2019 May; 419():40-54. PubMed ID: 30914192
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.
    Stiborova M; Manhartova Z; Hodek P; Adam V; Kizek R; Eckschlager T; Frei E
    Neuro Endocrinol Lett; 2015; 36 Suppl 1():22-8. PubMed ID: 26757112
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Formation and persistence of DNA adducts of anticancer drug ellipticine in rats.
    Stiborová M; Rupertová M; Aimová D; Ryslavá H; Frei E
    Toxicology; 2007 Jul; 236(1-2):50-60. PubMed ID: 17482743
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice.
    Stiborova M; Cerna V; Moserova M; Arlt VM; Frei E
    Neuro Endocrinol Lett; 2013; 34 Suppl 2():43-54. PubMed ID: 24362092
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.
    Stiborova M; Moserova M; Mrazova B; Kotrbova V; Frei E
    Neuro Endocrinol Lett; 2010; 31 Suppl 2():26-35. PubMed ID: 21187821
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.
    Stiborová M; Indra R; Moserová M; Cerná V; Rupertová M; Martínek V; Eckschlager T; Kizek R; Frei E
    Chem Res Toxicol; 2012 May; 25(5):1075-85. PubMed ID: 22390216
    [TBL] [Abstract][Full Text] [Related]  

  • 31. DNA adduct formation by 7H-dibenzo[c,g]carbazole and its tissue- and organ-specific derivatives in Chinese hamster V79 cell lines stably expressing cytochrome P450 enzymes.
    Gábelová A; Binková B; Valovicová Z; Srám RJ
    Environ Mol Mutagen; 2004; 44(5):448-58. PubMed ID: 15534862
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Oxidation of an antitumor drug ellipticine by peroxidases.
    Poljaková J; Forsterová K; Sulc M; Frei E; Stiborová M
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2005 Dec; 149(2):449-53. PubMed ID: 16601808
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.
    Stiborová M; Borek-Dohalská L; Aimová D; Kotrbová V; Kukacková K; Janouchová K; Rupertová M; Ryslavá H; Hudecek J; Frei E
    Gen Physiol Biophys; 2006 Sep; 25(3):245-61. PubMed ID: 17197724
    [TBL] [Abstract][Full Text] [Related]  

  • 34. 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.
    Arlt VM; Hewer A; Sorg BL; Schmeiser HH; Phillips DH; Stiborova M
    Chem Res Toxicol; 2004 Aug; 17(8):1092-101. PubMed ID: 15310241
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
    Luch A; Coffing SL; Tang YM; Schneider A; Soballa V; Greim H; Jefcoate CR; Seidel A; Greenlee WF; Baird WM; Doehmer J
    Chem Res Toxicol; 1998 Jun; 11(6):686-95. PubMed ID: 9625737
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
    Multon E; Riou JF; LeFevre D; Ahomadegbe JC; Riou G
    Biochem Pharmacol; 1989 Jul; 38(13):2077-86. PubMed ID: 2544183
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Formation of DNA adducts from oil-derived products analyzed by 32P-HPLC.
    Akkineni LK; Zeisig M; Baranczewski P; Ekström LG; Möller L
    Arch Toxicol; 2001 Jan; 74(11):720-31. PubMed ID: 11218050
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Cytochrome
    Stiborová M; Indra R; Frei E; Kopečková K; Schmeiser HH; Eckschlager T; Adam V; Heger Z; Arlt VM; Martínek V
    Monatsh Chem; 2017; 148(11):1983-1991. PubMed ID: 29104319
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.
    Luch A; Kishiyama S; Seidel A; Doehmer J; Greim H; Baird WM
    Cancer Res; 1999 Sep; 59(18):4603-9. PubMed ID: 10493514
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.
    Arlt VM; Stiborova M; Hewer A; Schmeiser HH; Phillips DH
    Cancer Res; 2003 Jun; 63(11):2752-61. PubMed ID: 12782579
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.