BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

348 related articles for article (PubMed ID: 12124303)

  • 1. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.
    Crewe HK; Notley LM; Wunsch RM; Lennard MS; Gillam EM
    Drug Metab Dispos; 2002 Aug; 30(8):869-74. PubMed ID: 12124303
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives.
    Notley LM; Crewe KH; Taylor PJ; Lennard MS; Gillam EM
    Chem Res Toxicol; 2005 Oct; 18(10):1611-8. PubMed ID: 16533026
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
    Dehal SS; Kupfer D
    Cancer Res; 1997 Aug; 57(16):3402-6. PubMed ID: 9270005
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes.
    Crewe HK; Ellis SW; Lennard MS; Tucker GT
    Biochem Pharmacol; 1997 Jan; 53(2):171-8. PubMed ID: 9037249
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.
    Kim SY; Suzuki N; Santosh Laxmi YR; Rieger R; Shibutani S
    Chem Res Toxicol; 2003 Sep; 16(9):1138-44. PubMed ID: 12971802
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.
    Avent KM; DeVoss JJ; Gillam EM
    Chem Res Toxicol; 2006 Jul; 19(7):914-20. PubMed ID: 16841959
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.
    Patten CJ; Smith TJ; Friesen MJ; Tynes RE; Yang CS; Murphy SE
    Carcinogenesis; 1997 Aug; 18(8):1623-30. PubMed ID: 9276639
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.
    Ono S; Hatanaka T; Miyazawa S; Tsutsui M; Aoyama T; Gonzalez FJ; Satoh T
    Xenobiotica; 1996 Nov; 26(11):1155-66. PubMed ID: 8948091
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Cytochrome P450 Enzyme Responsible for the Production of (Z)-Norendoxifen in vitro.
    Ma J; Chu Z; Lu JBL; Liu J; Zhang Q; Liu Z; Tang D
    Chem Biodivers; 2018 Jan; 15(1):. PubMed ID: 28834279
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9.
    Tracy TS; Marra C; Wrighton SA; Gonzalez FJ; Korzekwa KR
    Biochem Pharmacol; 1996 Oct; 52(8):1305-9. PubMed ID: 8937439
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biotransformation of tamoxifen in a human endometrial explant culture model.
    Sharma M; Shubert DE; Sharma M; Lewis J; McGarrigle BP; Bofinger DP; Olson JR
    Chem Biol Interact; 2003 Dec; 146(3):237-49. PubMed ID: 14642736
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
    Heyn H; White RB; Stevens JC
    Drug Metab Dispos; 1996 Sep; 24(9):948-54. PubMed ID: 8886603
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.
    Koehl W; Amin S; Staretz ME; Ueng YF; Yamazaki H; Tateishi T; Guengerich FP; Hecht SS
    Cancer Res; 1996 Jan; 56(2):316-24. PubMed ID: 8542586
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes.
    Yamazaki H; Inoue K; Hashimoto M; Shimada T
    Arch Toxicol; 1999 Mar; 73(2):65-70. PubMed ID: 10350185
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.
    Williams ML; Lennard MS; Martin IJ; Tucker GT
    Carcinogenesis; 1994 Dec; 15(12):2733-8. PubMed ID: 8001229
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
    Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In vitro metabolism and drug interaction potential of a new highly potent anti-cytomegalovirus molecule, CMV423 (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine I-carboxamide).
    Bournique B; Lambert N; Boukaiba R; Martinet M
    Br J Clin Pharmacol; 2001 Jul; 52(1):53-63. PubMed ID: 11453890
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs.
    Mancy A; Antignac M; Minoletti C; Dijols S; Mouries V; Duong NT; Battioni P; Dansette PM; Mansuy D
    Biochemistry; 1999 Oct; 38(43):14264-70. PubMed ID: 10572000
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
    Marill J; Cresteil T; Lanotte M; Chabot GG
    Mol Pharmacol; 2000 Dec; 58(6):1341-8. PubMed ID: 11093772
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Human cytochrome P-450 metabolism of retinals to retinoic acids.
    Zhang QY; Dunbar D; Kaminsky L
    Drug Metab Dispos; 2000 Mar; 28(3):292-7. PubMed ID: 10681373
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.