108 related articles for article (PubMed ID: 12127525)
1. Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding.
Chauret N; Guay D; Li C; Day S; Silva J; Blouin M; Ducharme Y; Yergey JA; Nicoll-Griffith DA
Bioorg Med Chem Lett; 2002 Aug; 12(16):2149-52. PubMed ID: 12127525
[TBL] [Abstract][Full Text] [Related]
2. Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.
Li C; Chauret N; Trimble LA; Nicoll-Griffith DA; Silva JM; MacDonald D; Perrier H; Yergey JA; Parton T; Alexander RP; Warrellow GJ
Drug Metab Dispos; 2001 Mar; 29(3):232-41. PubMed ID: 11181489
[TBL] [Abstract][Full Text] [Related]
3. Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.
Hulme C; Poli GB; Huang FC; Souness JE; Djuric SW
Bioorg Med Chem Lett; 1998 Jan; 8(2):175-8. PubMed ID: 9871649
[TBL] [Abstract][Full Text] [Related]
4. Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.
Napoletano M; Norcini G; Pellacini F; Marchini F; Morazzoni G; Ferlenga P; Pradella L
Bioorg Med Chem Lett; 2001 Jan; 11(1):33-7. PubMed ID: 11140727
[TBL] [Abstract][Full Text] [Related]
5. Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.
Guay D; Hamel P; Blouin M; Brideau C; Chan CC; Chauret N; Ducharme Y; Huang Z; Girard M; Jones TR; Laliberté F; Masson P; McAuliffe M; Piechuta H; Silva J; Young RN; Girard Y
Bioorg Med Chem Lett; 2002 Jun; 12(11):1457-61. PubMed ID: 12031319
[TBL] [Abstract][Full Text] [Related]
6. Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.
Frenette R; Blouin M; Brideau C; Chauret N; Ducharme Y; Friesen RW; Hamel P; Jones TR; Laliberté F; Li C; Masson P; McAuliffe M; Girard Y
Bioorg Med Chem Lett; 2002 Oct; 12(20):3009-13. PubMed ID: 12270195
[TBL] [Abstract][Full Text] [Related]
7. 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Buckley GM; Cooper N; Davenport RJ; Dyke HJ; Galleway FP; Gowers L; Haughan AF; Kendall HJ; Lowe C; Montana JG; Oxford J; Peake JC; Picken CL; Richard MD; Sabin V; Sharpe A; Warneck JB
Bioorg Med Chem Lett; 2002 Feb; 12(3):509-12. PubMed ID: 11814830
[TBL] [Abstract][Full Text] [Related]
8. The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I.
Napoletano M; Norcini G; Pellacini F; Marchini F; Morazzoni G; Ferlenga P; Pradella L
Bioorg Med Chem Lett; 2000 Oct; 10(19):2235-8. PubMed ID: 11012037
[TBL] [Abstract][Full Text] [Related]
9. Discovery of new orally active phosphodiesterase (PDE4) inhibitors.
Ochiai H; Ishida A; Ohtani T; Kusumi K; Kishikawa K; Yamamoto S; Takeda H; Obata T; Nakai H; Toda M
Chem Pharm Bull (Tokyo); 2004 Sep; 52(9):1098-104. PubMed ID: 15340197
[TBL] [Abstract][Full Text] [Related]
10. 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.
Whitehead JW; Lee GP; Gharagozloo P; Hofer P; Gehrig A; Wintergerst P; Smyth D; McCoull W; Hachicha M; Patel A; Kyle DJ
J Med Chem; 2005 Feb; 48(4):1237-43. PubMed ID: 15715490
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).
Woodring JL; Bland ND; Ochiana SO; Campbell RK; Pollastri MP
Bioorg Med Chem Lett; 2013 Nov; 23(21):5971-4. PubMed ID: 24042005
[TBL] [Abstract][Full Text] [Related]
12. 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Buckley GM; Cooper N; Dyke HJ; Galleway FP; Gowers L; Haughan AF; Kendall HJ; Lowe C; Maxey R; Montana JG; Naylor R; Oxford J; Peake JC; Picken CL; Runcie KA; Sabin V; Sharpe A; Warneck JB
Bioorg Med Chem Lett; 2002 Jun; 12(12):1613-5. PubMed ID: 12039574
[TBL] [Abstract][Full Text] [Related]
13. Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
Friesen RW; Ducharme Y; Ball RG; Blouin M; Boulet L; Côté B; Frenette R; Girard M; Guay D; Huang Z; Jones TR; Laliberté F; Lynch JJ; Mancini J; Martins E; Masson P; Muise E; Pon DJ; Siegl PK; Styhler A; Tsou NN; Turner MJ; Young RN; Girard Y
J Med Chem; 2003 Jun; 46(12):2413-26. PubMed ID: 12773045
[TBL] [Abstract][Full Text] [Related]
14. New orally active PDE4 inhibitors with therapeutic potential.
Ochiai H; Ishida A; Ohtani T; Kusumi K; Kishikawa K; Yamamoto S; Takeda H; Obata T; Nakai H; Toda M
Bioorg Med Chem; 2004 Aug; 12(15):4089-100. PubMed ID: 15246087
[TBL] [Abstract][Full Text] [Related]
15. N-arylrolipram derivatives as potent and selective PDE4 inhibitors.
Bacher E; Boer C; Bray-French K; Demnitz FW; Keller TH; Mazzoni L; Müller T; Walker C
Bioorg Med Chem Lett; 1998 Nov; 8(22):3229-34. PubMed ID: 9873708
[TBL] [Abstract][Full Text] [Related]
16. Substituted furans as inhibitors of the PDE4 enzyme.
Perrier H; Bayly C; Laliberté F; Huang Z; Rasori R; Robichaud A; Girard Y; Macdonald D
Bioorg Med Chem Lett; 1999 Feb; 9(3):323-6. PubMed ID: 10091677
[TBL] [Abstract][Full Text] [Related]
17. 7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.
Buckley G; Cooper N; Dyke HJ; Galleway F; Gowers L; Gregory JC; Hannah DR; Haughan AF; Hellewell PG; Kendall HJ; Lowe C; Maxey R; Montana JG; Naylor R; Picken CL; Runcie KA; Sabin V; Tuladhar BR; Warneck JB
Bioorg Med Chem Lett; 2000 Sep; 10(18):2137-40. PubMed ID: 10999488
[TBL] [Abstract][Full Text] [Related]
18. New orally active PDE4 inhibitors with therapeutic potential.
Ochiai H; Ishida A; Ohtani T; Kusumi K; Kishikawa K; Obata T; Nakai H; Toda M
Bioorg Med Chem Lett; 2004 Jan; 14(1):29-32. PubMed ID: 14684291
[TBL] [Abstract][Full Text] [Related]
19. Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.
Bateman KP; Trimble L; Chauret N; Silva J; Day S; Macdonald D; Dube D; Gallant M; Mastracchio A; Perrier H; Girard Y; Nicoll-Griffith D
J Mass Spectrom; 2006 Jun; 41(6):771-80. PubMed ID: 16705670
[TBL] [Abstract][Full Text] [Related]
20. Behavioural effects of selective PDE4 inhibitors in relation to inhibition of catalytic activity and competition for [3H]rolipram binding.
Kapui Z; Bence J; Boronkay E; Mikus E; Urbán Szabó K; Baranyi A; Arányi P
Neurobiology (Bp); 1999; 7(1):71-3. PubMed ID: 10746252
[No Abstract] [Full Text] [Related]
[Next] [New Search]