These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 12130672)

  • 21. Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene.
    Zheng X; Chen X; Zhang T; Zhan M; Zhan CG; Zheng F
    Org Biomol Chem; 2020 Mar; 18(10):1968-1977. PubMed ID: 32101217
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
    Xue L; Ko MC; Tong M; Yang W; Hou S; Fang L; Liu J; Zheng F; Woods JH; Tai HH; Zhan CG
    Mol Pharmacol; 2011 Feb; 79(2):290-7. PubMed ID: 20971807
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Visualizing viral transduction of a cocaine-hydrolyzing, human butyrylcholinesterase in rats.
    Gao Y; Brimijoin S
    Chem Biol Interact; 2005 Dec; 157-158():97-103. PubMed ID: 16243302
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.
    Brimijoin S; Gao Y; Anker JJ; Gliddon LA; Lafleur D; Shah R; Zhao Q; Singh M; Carroll ME
    Neuropsychopharmacology; 2008 Oct; 33(11):2715-25. PubMed ID: 18199998
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Most efficient cocaine hydrolase designed by virtual screening of transition states.
    Zheng F; Yang W; Ko MC; Liu J; Cho H; Gao D; Tong M; Tai HH; Woods JH; Zhan CG
    J Am Chem Soc; 2008 Sep; 130(36):12148-55. PubMed ID: 18710224
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis.
    Yang W; Pan Y; Fang L; Gao D; Zheng F; Zhan CG
    J Phys Chem B; 2010 Aug; 114(33):10889-96. PubMed ID: 20677742
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase.
    Fang L; Hou S; Xue L; Zheng F; Zhan CG
    Chem Biol Interact; 2014 May; 214():18-25. PubMed ID: 24582612
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Potential anti-obesity effects of a long-acting cocaine hydrolase.
    Zheng X; Deng J; Zhang T; Yao J; Zheng F; Zhan CG
    Chem Biol Interact; 2016 Nov; 259(Pt B):99-103. PubMed ID: 27163854
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase.
    Millard CB; Lockridge O; Broomfield CA
    Biochemistry; 1998 Jan; 37(1):237-47. PubMed ID: 9425044
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.
    Murthy V; Geng L; Gao Y; Zhang B; Miller JD; Reyes S; Brimijoin S
    Cell Mol Neurobiol; 2015 Aug; 35(6):819-26. PubMed ID: 25814464
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Computational redesign of human butyrylcholinesterase for anticocaine medication.
    Pan Y; Gao D; Yang W; Cho H; Yang G; Tai HH; Zhan CG
    Proc Natl Acad Sci U S A; 2005 Nov; 102(46):16656-61. PubMed ID: 16275916
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.
    Duysen EG; Lockridge O
    Drug Metab Dispos; 2011 Aug; 39(8):1321-3. PubMed ID: 21540357
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.
    Gao D; Zhan CG
    Proteins; 2006 Jan; 62(1):99-110. PubMed ID: 16288482
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.
    Geng L; Gao Y; Chen X; Hou S; Zhan CG; Radic Z; Parks RJ; Russell SJ; Pham L; Brimijoin S
    PLoS One; 2013; 8(6):e67446. PubMed ID: 23840704
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice.
    Brimijoin S; Orson F; Kosten TR; Kinsey B; Shen XY; White SJ; Gao Y
    Chem Biol Interact; 2013 Mar; 203(1):212-6. PubMed ID: 22960160
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase.
    Carmona GN; Schindler CW; Shoaib M; Jufer R; Cone EJ; Goldberg SR; Greig NH; Yu QS; Gorelick DA
    Exp Clin Psychopharmacol; 1998 Aug; 6(3):274-9. PubMed ID: 9725111
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Rational design of an enzyme mutant for anti-cocaine therapeutics.
    Zheng F; Zhan CG
    J Comput Aided Mol Des; 2008 Sep; 22(9):661-71. PubMed ID: 17989928
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.
    Mikami LR; Wieseler S; Souza RL; Schopfer LM; Nachon F; Lockridge O; Chautard-Freire-Maia EA
    Pharmacogenet Genomics; 2008 Mar; 18(3):213-8. PubMed ID: 18300943
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Reaction pathway and free energy profile for prechemical reaction step of human butyrylcholinesterase-catalyzed hydrolysis of (-)-cocaine by combined targeted molecular dynamics and potential of mean force simulations.
    Huang X; Pan Y; Zheng F; Zhan CG
    J Phys Chem B; 2010 Oct; 114(42):13545-54. PubMed ID: 20883001
    [TBL] [Abstract][Full Text] [Related]  

  • 40. His-tag truncated butyrylcholinesterase as a useful construct for in vitro characterization of wild-type and variant butyrylcholinesterases.
    Ralph EC; Xiang L; Cashman JR; Zhang J
    Protein Expr Purif; 2011 Nov; 80(1):22-7. PubMed ID: 21802514
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.