452 related articles for article (PubMed ID: 12130709)
1. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
Wang DS; Jonker JW; Kato Y; Kusuhara H; Schinkel AH; Sugiyama Y
J Pharmacol Exp Ther; 2002 Aug; 302(2):510-5. PubMed ID: 12130709
[TBL] [Abstract][Full Text] [Related]
2. A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes.
Sogame Y; Kitamura A; Yabuki M; Komuro S
Biopharm Drug Dispos; 2009 Nov; 30(8):476-84. PubMed ID: 19768675
[TBL] [Abstract][Full Text] [Related]
3. Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.
Jonker JW; Wagenaar E; Mol CA; Buitelaar M; Koepsell H; Smit JW; Schinkel AH
Mol Cell Biol; 2001 Aug; 21(16):5471-7. PubMed ID: 11463829
[TBL] [Abstract][Full Text] [Related]
4. Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.
Ishiguro N; Saito A; Yokoyama K; Morikawa M; Igarashi T; Tamai I
Drug Metab Dispos; 2005 Apr; 33(4):495-9. PubMed ID: 15640376
[TBL] [Abstract][Full Text] [Related]
5. Liver uptake of biguanides in rats.
Sogame Y; Kitamura A; Yabuki M; Komuro S
Biomed Pharmacother; 2011 Sep; 65(6):451-5. PubMed ID: 21880461
[TBL] [Abstract][Full Text] [Related]
6. Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.
Higgins JW; Bedwell DW; Zamek-Gliszczynski MJ
Drug Metab Dispos; 2012 Jun; 40(6):1170-7. PubMed ID: 22407892
[TBL] [Abstract][Full Text] [Related]
7. Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.
Kimura N; Masuda S; Tanihara Y; Ueo H; Okuda M; Katsura T; Inui K
Drug Metab Pharmacokinet; 2005 Oct; 20(5):379-86. PubMed ID: 16272756
[TBL] [Abstract][Full Text] [Related]
8. Identification of human metabolites of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel If channel inhibitor, and investigation of the transporter-mediated renal and hepatic excretion of these metabolites.
Umehara K; Shirai N; Iwatsubo T; Noguchi K; Usui T; Kamimura H
Drug Metab Dispos; 2009 Aug; 37(8):1646-57. PubMed ID: 19439489
[TBL] [Abstract][Full Text] [Related]
9. Functional mapping of rbOCT1 and rbOCT2 activity in the S2 segment of rabbit proximal tubule.
Kaewmokul S; Chatsudthipong V; Evans KK; Dantzler WH; Wright SH
Am J Physiol Renal Physiol; 2003 Dec; 285(6):F1149-59. PubMed ID: 12944320
[TBL] [Abstract][Full Text] [Related]
10. Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.
Maeda T; Oyabu M; Yotsumoto T; Higashi R; Nagata K; Yamazoe Y; Tamai I
Drug Metab Dispos; 2007 Sep; 35(9):1580-6. PubMed ID: 17553914
[TBL] [Abstract][Full Text] [Related]
11. Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.
Horie A; Sakata J; Nishimura M; Ishida K; Taguchi M; Hashimoto Y
Biopharm Drug Dispos; 2011 Jul; 32(5):253-60. PubMed ID: 21567399
[TBL] [Abstract][Full Text] [Related]
12. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis.
Denk GU; Soroka CJ; Mennone A; Koepsell H; Beuers U; Boyer JL
Hepatology; 2004 May; 39(5):1382-9. PubMed ID: 15122767
[TBL] [Abstract][Full Text] [Related]
13. Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats.
Umehara KI; Iwatsubo T; Noguchi K; Kamimura H
Xenobiotica; 2007 Aug; 37(8):818-31. PubMed ID: 17701831
[TBL] [Abstract][Full Text] [Related]
14. Relevance of the OCT1 transporter to the antineoplastic effect of biguanides.
Segal ED; Yasmeen A; Beauchamp MC; Rosenblatt J; Pollak M; Gotlieb WH
Biochem Biophys Res Commun; 2011 Nov; 414(4):694-9. PubMed ID: 21986525
[TBL] [Abstract][Full Text] [Related]
15. Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.
Zolk O; Solbach TF; König J; Fromm MF
Drug Metab Dispos; 2009 Jun; 37(6):1312-8. PubMed ID: 19251820
[TBL] [Abstract][Full Text] [Related]
16. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1).
Dresser MJ; Gray AT; Giacomini KM
J Pharmacol Exp Ther; 2000 Mar; 292(3):1146-52. PubMed ID: 10688634
[TBL] [Abstract][Full Text] [Related]
17. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.
Ahlin G; Chen L; Lazorova L; Chen Y; Ianculescu AG; Davis RL; Giacomini KM; Artursson P
Pharmacogenomics J; 2011 Dec; 11(6):400-11. PubMed ID: 20567254
[TBL] [Abstract][Full Text] [Related]
18. Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.
Umehara KI; Iwatsubo T; Noguchi K; Kamimura H
Xenobiotica; 2007 Jun; 37(6):618-34. PubMed ID: 17614008
[TBL] [Abstract][Full Text] [Related]
19. Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters.
Choi MK; Jin QR; Ahn SH; Bae MA; Song IS
Xenobiotica; 2010 Dec; 40(12):817-25. PubMed ID: 20863201
[TBL] [Abstract][Full Text] [Related]
20. Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.
Higgins JW; Ke AB; Zamek-Gliszczynski MJ
Drug Metab Dispos; 2014 Nov; 42(11):1780-4. PubMed ID: 25106415
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]