138 related articles for article (PubMed ID: 12130724)
1. bis-Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides are highly selectively taken up by the liver.
Bijsterbosch MK; Manoharan M; Dorland R; Van Veghel R; Biessen EA; Van Berkel TJ
J Pharmacol Exp Ther; 2002 Aug; 302(2):619-26. PubMed ID: 12130724
[TBL] [Abstract][Full Text] [Related]
2. Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation.
Bijsterbosch MK; Rump ET; De Vrueh RL; Dorland R; van Veghel R; Tivel KL; Biessen EA; van Berkel TJ; Manoharan M
Nucleic Acids Res; 2000 Jul; 28(14):2717-25. PubMed ID: 10908328
[TBL] [Abstract][Full Text] [Related]
3. In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.
Bijsterbosch MK; Manoharan M; Rump ET; De Vrueh RL; van Veghel R; Tivel KL; Biessen EA; Bennett CF; Cook PD; van Berkel TJ
Nucleic Acids Res; 1997 Aug; 25(16):3290-6. PubMed ID: 9241243
[TBL] [Abstract][Full Text] [Related]
4. Delivery of cholesteryl-conjugated phosphorothioate oligodeoxynucleotides to Kupffer cells by lactosylated low-density lipoprotein.
Bijsterbosch MK; Manoharan M; Dorland R; Waarlo IH; Biessen EA; van Berkel TJ
Biochem Pharmacol; 2001 Sep; 62(5):627-33. PubMed ID: 11585059
[TBL] [Abstract][Full Text] [Related]
5. Modification of the plasma clearance and liver uptake of steroid ester-conjugated oligodeoxynucleotides by association with (lactosylated) low-density lipoprotein.
Rump ET; de Vrueh RL; Manoharan M; Waarlo IH; van Veghel R; Biessen EA; van Berkel TJ; Bijsterbosch MK
Biochem Pharmacol; 2000 Jun; 59(11):1407-16. PubMed ID: 10751550
[TBL] [Abstract][Full Text] [Related]
6. Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302).
Watanabe TA; Geary RS; Levin AA
Oligonucleotides; 2006; 16(2):169-80. PubMed ID: 16764540
[TBL] [Abstract][Full Text] [Related]
7. Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice.
Butler M; Crooke RM; Graham MJ; Lemonidis KM; Lougheed M; Murray SF; Witchell D; Steinbrecher U; Bennett CF
J Pharmacol Exp Ther; 2000 Feb; 292(2):489-96. PubMed ID: 10640284
[TBL] [Abstract][Full Text] [Related]
8. Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system.
Wu D; Boado RJ; Pardridge WM
J Pharmacol Exp Ther; 1996 Jan; 276(1):206-11. PubMed ID: 8558431
[TBL] [Abstract][Full Text] [Related]
9. Comparison of the pharmacokinetics of subcutaneous and intravenous administration of a phosphorothioate oligodeoxynucleotide in cynomolgus monkeys.
Leeds JM; Henry SP; Geary R; Burckin T; Levin AA
Antisense Nucleic Acid Drug Dev; 2000 Dec; 10(6):435-41. PubMed ID: 11198927
[TBL] [Abstract][Full Text] [Related]
10. Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with (18)F-incorporated oligodeoxynucleotides.
Mukai H; Ozaki D; Cui Y; Kuboyama T; Yamato-Nagata H; Onoe K; Takahashi M; Wada Y; Imanishi T; Kodama T; Obika S; Suzuki M; Doi H; Watanabe Y
J Control Release; 2014 Apr; 180():92-9. PubMed ID: 24566256
[TBL] [Abstract][Full Text] [Related]
11. Liver uptake of phosphodiester oligodeoxynucleotides is mediated by scavenger receptors.
Biessen EA; Vietsch H; Kuiper J; Bijsterbosch MK; Berkel TJ
Mol Pharmacol; 1998 Feb; 53(2):262-9. PubMed ID: 9463484
[TBL] [Abstract][Full Text] [Related]
12. Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice.
Rifai A; Brysch W; Fadden K; Clark J; Schlingensiepen KH
Am J Pathol; 1996 Aug; 149(2):717-25. PubMed ID: 8702009
[TBL] [Abstract][Full Text] [Related]
13. Pharmacokinetic properties of several novel oligonucleotide analogs in mice.
Crooke ST; Graham MJ; Zuckerman JE; Brooks D; Conklin BS; Cummins LL; Greig MJ; Guinosso CJ; Kornbrust D; Manoharan M; Sasmor HM; Schleich T; Tivel KL; Griffey RH
J Pharmacol Exp Ther; 1996 May; 277(2):923-37. PubMed ID: 8627575
[TBL] [Abstract][Full Text] [Related]
14. Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo.
Biessen EA; Vietsch H; Rump ET; Fluiter K; Kuiper J; Bijsterbosch MK; van Berkel TJ
Biochem J; 1999 Jun; 340 ( Pt 3)(Pt 3):783-92. PubMed ID: 10359665
[TBL] [Abstract][Full Text] [Related]
15. Biodistribution, stability, and antiviral efficacy of liposome-entrapped phosphorothioate antisense oligodeoxynucleotides in ducks for the treatment of chronic duck hepatitis B virus infection.
Soni PN; Brown D; Saffie R; Savage K; Moore D; Gregoriadis G; Dusheiko GM
Hepatology; 1998 Nov; 28(5):1402-10. PubMed ID: 9794928
[TBL] [Abstract][Full Text] [Related]
16. Quantitative analysis of the targeting of mannose-terminal glucocerebrosidase. Predominant uptake by liver endothelial cells.
Bijsterbosch MK; Donker W; van de Bilt H; van Weely S; van Berkel TJ; Aerts JM
Eur J Biochem; 1996 Apr; 237(2):344-9. PubMed ID: 8647071
[TBL] [Abstract][Full Text] [Related]
17. Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1.
Henry SP; Templin MV; Gillett N; Rojko J; Levin AA
Toxicol Pathol; 1999; 27(1):95-100. PubMed ID: 10367680
[TBL] [Abstract][Full Text] [Related]
18. Pharmacokinetics, tissue distribution, and stability of antisense oligodeoxynucleotide phosphorothioate ISIS 3466 in mice.
Saijo Y; Perlaky L; Wang H; Busch H
Oncol Res; 1994; 6(6):243-9. PubMed ID: 7865900
[TBL] [Abstract][Full Text] [Related]
19. Cellular distribution of phosphorothioate oligodeoxynucleotides in normal rodent tissues.
Butler M; Stecker K; Bennett CF
Lab Invest; 1997 Oct; 77(4):379-88. PubMed ID: 9354772
[TBL] [Abstract][Full Text] [Related]
20. Preclinical evaluation of the effects of a novel antisense compound targeting C-raf kinase in mice and monkeys.
Monteith DK; Geary RS; Leeds JM; Johnston J; Monia BP; Levin AA
Toxicol Sci; 1998 Dec; 46(2):365-75. PubMed ID: 10048140
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]