BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

390 related articles for article (PubMed ID: 12145204)

  • 1. Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.
    Lin HK; Wang L; Hu YC; Altuwaijri S; Chang C
    EMBO J; 2002 Aug; 21(15):4037-48. PubMed ID: 12145204
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Artemisinin disrupts androgen responsiveness of human prostate cancer cells by stimulating the 26S proteasome-mediated degradation of the androgen receptor protein.
    Steely AM; Willoughby JA; Sundar SN; Aivaliotis VI; Firestone GL
    Anticancer Drugs; 2017 Oct; 28(9):1018-1031. PubMed ID: 28708672
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway.
    Deep G; Oberlies NH; Kroll DJ; Agarwal R
    Oncogene; 2008 Jun; 27(28):3986-98. PubMed ID: 18332867
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hypophosphorylation of Mdm2 augments p53 stability.
    Blattner C; Hay T; Meek DW; Lane DP
    Mol Cell Biol; 2002 Sep; 22(17):6170-82. PubMed ID: 12167711
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
    Milne D; Kampanis P; Nicol S; Dias S; Campbell DG; Fuller-Pace F; Meek D
    FEBS Lett; 2004 Nov; 577(1-2):270-6. PubMed ID: 15527798
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.
    Feng J; Tamaskovic R; Yang Z; Brazil DP; Merlo A; Hess D; Hemmings BA
    J Biol Chem; 2004 Aug; 279(34):35510-7. PubMed ID: 15169778
    [TBL] [Abstract][Full Text] [Related]  

  • 7. p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2).
    Liu T; Li Y; Gu H; Zhu G; Li J; Cao L; Li F
    J Biol Chem; 2013 Feb; 288(5):3359-69. PubMed ID: 23132866
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress.
    Saito A; Hayashi T; Okuno S; Nishi T; Chan PH
    J Cereb Blood Flow Metab; 2005 Feb; 25(2):267-80. PubMed ID: 15678128
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
    Ogawara Y; Kishishita S; Obata T; Isazawa Y; Suzuki T; Tanaka K; Masuyama N; Gotoh Y
    J Biol Chem; 2002 Jun; 277(24):21843-50. PubMed ID: 11923280
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation.
    Gaughan L; Logan IR; Neal DE; Robson CN
    Nucleic Acids Res; 2005; 33(1):13-26. PubMed ID: 15640443
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
    Linn DE; Yang X; Xie Y; Alfano A; Deshmukh D; Wang X; Shimelis H; Chen H; Li W; Xu K; Chen M; Qiu Y
    J Biol Chem; 2012 Jun; 287(27):22959-68. PubMed ID: 22584579
    [TBL] [Abstract][Full Text] [Related]  

  • 12. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
    Choy MK; Movassagh M; Bennett MR; Foo RS
    J Cell Physiol; 2010 Mar; 222(3):635-9. PubMed ID: 19950214
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.
    Girnita L; Girnita A; Larsson O
    Proc Natl Acad Sci U S A; 2003 Jul; 100(14):8247-52. PubMed ID: 12821780
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.
    Legube G; Linares LK; Lemercier C; Scheffner M; Khochbin S; Trouche D
    EMBO J; 2002 Apr; 21(7):1704-12. PubMed ID: 11927554
    [TBL] [Abstract][Full Text] [Related]  

  • 15. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
    Fu W; Ma Q; Chen L; Li P; Zhang M; Ramamoorthy S; Nawaz Z; Shimojima T; Wang H; Yang Y; Shen Z; Zhang Y; Zhang X; Nicosia SV; Zhang Y; Pledger JW; Chen J; Bai W
    J Biol Chem; 2009 May; 284(21):13987-4000. PubMed ID: 19321440
    [TBL] [Abstract][Full Text] [Related]  

  • 16. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
    Ito A; Kawaguchi Y; Lai CH; Kovacs JJ; Higashimoto Y; Appella E; Yao TP
    EMBO J; 2002 Nov; 21(22):6236-45. PubMed ID: 12426395
    [TBL] [Abstract][Full Text] [Related]  

  • 17. MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4.
    Marcar L; Ihrig B; Hourihan J; Bray SE; Quinlan PR; Jordan LB; Thompson AM; Hupp TR; Meek DW
    PLoS One; 2015; 10(5):e0127713. PubMed ID: 26001071
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.
    Li Q; Li Y; Gu B; Fang L; Zhou P; Bao S; Huang L; Dai X
    J Biol Chem; 2015 Aug; 290(35):21553-67. PubMed ID: 26170450
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers.
    Lin HK; Hu YC; Yang L; Altuwaijri S; Chen YT; Kang HY; Chang C
    J Biol Chem; 2003 Dec; 278(51):50902-7. PubMed ID: 14555644
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
    Cha TL; Qiu L; Chen CT; Wen Y; Hung MC
    Cancer Res; 2005 Mar; 65(6):2287-95. PubMed ID: 15781642
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.