BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

165 related articles for article (PubMed ID: 12145638)

  • 1. Presenilins are not required for A beta 42 production in the early secretory pathway.
    Wilson CA; Doms RW; Zheng H; Lee VM
    Nat Neurosci; 2002 Sep; 5(9):849-55. PubMed ID: 12145638
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F; Czech C; Esclaire F; Elyaman W; Yardin C; Baclet MC; Touchet N; Tremp G; Pradier L; Hugon J
    J Neurosci Res; 2002 Aug; 69(4):530-9. PubMed ID: 12210846
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
    Citron M; Eckman CB; Diehl TS; Corcoran C; Ostaszewski BL; Xia W; Levesque G; St George Hyslop P; Younkin SG; Selkoe DJ
    Neurobiol Dis; 1998 Aug; 5(2):107-16. PubMed ID: 9746908
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
    Wilson CA; Doms RW; Lee VM
    J Neurosci Res; 2003 Nov; 74(3):361-9. PubMed ID: 14598312
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Presenilin dependence of phospholipase C and protein kinase C signaling.
    Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Karlström H; Benedikz E; Cowburn RF
    J Neurochem; 2007 Aug; 102(3):848-57. PubMed ID: 17437536
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
    J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons.
    Yang Y; Cook DG
    Neuroscience; 2004; 124(3):501-5. PubMed ID: 14980721
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
    Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
    Réchards M; Xia W; Oorschot V; van Dijk S; Annaert W; Selkoe DJ; Klumperman J
    Traffic; 2006 Mar; 7(3):354-64. PubMed ID: 16497228
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells.
    Shin RW; Saido TC; Maeda M; Kitamoto T
    Neurosci Lett; 2005 Mar; 376(1):14-9. PubMed ID: 15694266
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.
    Armogida M; Petit A; Vincent B; Scarzello S; da Costa CA; Checler F
    Nat Cell Biol; 2001 Nov; 3(11):1030-3. PubMed ID: 11715026
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.