BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1134 related articles for article (PubMed ID: 12149650)

  • 1. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
    Choi Y; Zhang J; Murga C; Yu H; Koller E; Monia BP; Gutkind JS; Li W
    Oncogene; 2002 Aug; 21(34):5289-300. PubMed ID: 12149650
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.
    Zhang J; Choi Y; Mavromatis B; Lichtenstein A; Li W
    Oncogene; 2003 Sep; 22(40):6289-95. PubMed ID: 13679867
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
    Tang X; Powelka AM; Soriano NA; Czech MP; Guilherme A
    J Biol Chem; 2005 Jun; 280(23):22523-9. PubMed ID: 15824124
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of PTEN expression leading to high Akt activation in human multiple myelomas.
    Hyun T; Yam A; Pece S; Xie X; Zhang J; Miki T; Gutkind JS; Li W
    Blood; 2000 Nov; 96(10):3560-8. PubMed ID: 11071655
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.
    Sasaoka T; Kikuchi K; Wada T; Sato A; Hori H; Murakami S; Fukui K; Ishihara H; Aota R; Kimura I; Kobayashi M
    Endocrinology; 2003 Sep; 144(9):4204-14. PubMed ID: 12933696
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo.
    Ge NL; Rudikoff S
    Oncogene; 2000 Aug; 19(36):4091-5. PubMed ID: 10962569
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.
    Murakami S; Sasaoka T; Wada T; Fukui K; Nagira K; Ishihara H; Usui I; Kobayashi M
    Endocrinology; 2004 Jul; 145(7):3215-23. PubMed ID: 15044364
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.
    Pene F; Claessens YE; Muller O; Viguié F; Mayeux P; Dreyfus F; Lacombe C; Bouscary D
    Oncogene; 2002 Sep; 21(43):6587-97. PubMed ID: 12242656
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
    Freeburn RW; Wright KL; Burgess SJ; Astoul E; Cantrell DA; Ward SG
    J Immunol; 2002 Nov; 169(10):5441-50. PubMed ID: 12421919
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins.
    Welsh N; Makeeva N; Welsh M
    Mol Med; 2002 Nov; 8(11):695-704. PubMed ID: 12520086
    [TBL] [Abstract][Full Text] [Related]  

  • 11. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.
    Weng LP; Smith WM; Dahia PL; Ziebold U; Gil E; Lees JA; Eng C
    Cancer Res; 1999 Nov; 59(22):5808-14. PubMed ID: 10582703
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells.
    Nielsen-Preiss SM; Silva SR; Gillette JM
    J Cell Biochem; 2003 Dec; 90(5):964-75. PubMed ID: 14624456
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.
    Kandasamy K; Srivastava RK
    Cancer Res; 2002 Sep; 62(17):4929-37. PubMed ID: 12208743
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
    Horn S; Endl E; Fehse B; Weck MM; Mayr GW; Jücker M
    Leukemia; 2004 Nov; 18(11):1839-49. PubMed ID: 15457186
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.
    Wada T; Sasaoka T; Funaki M; Hori H; Murakami S; Ishiki M; Haruta T; Asano T; Ogawa W; Ishihara H; Kobayashi M
    Mol Cell Biol; 2001 Mar; 21(5):1633-46. PubMed ID: 11238900
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.
    Ishihara H; Sasaoka T; Ishiki M; Wada T; Hori H; Kagawa S; Kobayashi M
    Mol Endocrinol; 2002 Oct; 16(10):2371-81. PubMed ID: 12351701
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
    Taylor V; Wong M; Brandts C; Reilly L; Dean NM; Cowsert LM; Moodie S; Stokoe D
    Mol Cell Biol; 2000 Sep; 20(18):6860-71. PubMed ID: 10958682
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
    Lu Y; Yu Q; Liu JH; Zhang J; Wang H; Koul D; McMurray JS; Fang X; Yung WK; Siminovitch KA; Mills GB
    J Biol Chem; 2003 Oct; 278(41):40057-66. PubMed ID: 12869565
    [TBL] [Abstract][Full Text] [Related]  

  • 19. SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.
    Sasaoka T; Hori H; Wada T; Ishiki M; Haruta T; Ishihara H; Kobayashi M
    Diabetologia; 2001 Oct; 44(10):1258-67. PubMed ID: 11692174
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
    Ono H; Katagiri H; Funaki M; Anai M; Inukai K; Fukushima Y; Sakoda H; Ogihara T; Onishi Y; Fujishiro M; Kikuchi M; Oka Y; Asano T
    Mol Endocrinol; 2001 Aug; 15(8):1411-22. PubMed ID: 11463863
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 57.