BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 12161451)

  • 1. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.
    Pan YH; Yu BZ; Singer AG; Ghomashchi F; Lambeau G; Gelb MH; Jain MK; Bahnson BJ
    J Biol Chem; 2002 Aug; 277(32):29086-93. PubMed ID: 12161451
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tryptophan-containing mutant of human (group IIa) secreted phospholipase A2 has a dramatically increased ability to hydrolyze phosphatidylcholine vesicles and cell membranes.
    Baker SF; Othman R; Wilton DC
    Biochemistry; 1998 Sep; 37(38):13203-11. PubMed ID: 9748327
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2.
    Beers SA; Buckland AG; Giles N; Gelb MH; Wilton DC
    Biochemistry; 2003 Jun; 42(24):7326-38. PubMed ID: 12809488
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Thermodynamic and kinetic basis of interfacial activation: resolution of binding and allosteric effects on pancreatic phospholipase A2 at zwitterionic interfaces.
    Berg OG; Rogers J; Yu BZ; Yao J; Romsted LS; Jain MK
    Biochemistry; 1997 Nov; 36(47):14512-30. PubMed ID: 9398170
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface.
    Huang B; Yu BZ; Rogers J; Byeon IJ; Sekar K; Chen X; Sundaralingam M; Tsai MD; Jain MK
    Biochemistry; 1996 Sep; 35(37):12164-74. PubMed ID: 8810924
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells.
    Bezzine S; Koduri RS; Valentin E; Murakami M; Kudo I; Ghomashchi F; Sadilek M; Lambeau G; Gelb MH
    J Biol Chem; 2000 Feb; 275(5):3179-91. PubMed ID: 10652303
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural aspects of interfacial adsorption. A crystallographic and site-directed mutagenesis study of the phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus.
    Han SK; Yoon ET; Scott DL; Sigler PB; Cho W
    J Biol Chem; 1997 Feb; 272(6):3573-82. PubMed ID: 9013608
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential interfacial and substrate binding modes of mammalian pancreatic phospholipases A2: a comparison among human, bovine, and porcine enzymes.
    Snitko Y; Han SK; Lee BI; Cho W
    Biochemistry; 1999 Jun; 38(24):7803-10. PubMed ID: 10387020
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure, function and interfacial allosterism in phospholipase A2: insight from the anion-assisted dimer.
    Bahnson BJ
    Arch Biochem Biophys; 2005 Jan; 433(1):96-106. PubMed ID: 15581569
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2.
    Rogers J; Yu BZ; Tsai MD; Berg OG; Jain MK
    Biochemistry; 1998 Jun; 37(26):9549-56. PubMed ID: 9649338
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Roles of surface hydrophobic residues in the interfacial catalysis of bovine pancreatic phospholipase A2.
    Lee BI; Yoon ET; Cho W
    Biochemistry; 1996 Apr; 35(13):4231-40. PubMed ID: 8672459
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2.
    Yu BZ; Poi MJ; Ramagopal UA; Jain R; Ramakumar S; Berg OG; Tsai MD; Sekar K; Jain MK
    Biochemistry; 2000 Oct; 39(40):12312-23. PubMed ID: 11015210
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme.
    Koduri RS; Baker SF; Snitko Y; Han SK; Cho W; Wilton DC; Gelb MH
    J Biol Chem; 1998 Nov; 273(48):32142-53. PubMed ID: 9822691
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mapping the interfacial binding surface of human secretory group IIa phospholipase A2.
    Snitko Y; Koduri RS; Han SK; Othman R; Baker SF; Molini BJ; Wilton DC; Gelb MH; Cho W
    Biochemistry; 1997 Nov; 36(47):14325-33. PubMed ID: 9398150
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2.
    Hixon MS; Ball A; Gelb MH
    Biochemistry; 1998 Jun; 37(23):8516-26. PubMed ID: 9622504
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2.
    Bayburt T; Yu BZ; Street I; Ghomashchi F; Laliberté F; Perrier H; Wang Z; Homan R; Jain MK; Gelb MH
    Anal Biochem; 1995 Nov; 232(1):7-23. PubMed ID: 8600835
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
    Pan YH; Epstein TM; Jain MK; Bahnson BJ
    Biochemistry; 2001 Jan; 40(3):609-17. PubMed ID: 11170377
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.
    Ghomashchi F; Lin Y; Hixon MS; Yu BZ; Annand R; Jain MK; Gelb MH
    Biochemistry; 1998 May; 37(19):6697-710. PubMed ID: 9578553
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism.
    Edwards SH; Thompson D; Baker SF; Wood SP; Wilton DC
    Biochemistry; 2002 Dec; 41(52):15468-76. PubMed ID: 12501175
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2.
    Gora S; Lambeau G; Bollinger JG; Gelb M; Ninio E; Karabina SA
    Biochim Biophys Acta; 2006 Sep; 1761(9):1093-9. PubMed ID: 16962371
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.