503 related articles for article (PubMed ID: 12167569)
1. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
El-Sankary W; Bombail V; Gibson GG; Plant N
Drug Metab Dispos; 2002 Sep; 30(9):1029-34. PubMed ID: 12167569
[TBL] [Abstract][Full Text] [Related]
2. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Li T; Chiang JY
Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
[TBL] [Abstract][Full Text] [Related]
3. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
Pascussi JM; Drocourt L; Fabre JM; Maurel P; Vilarem MJ
Mol Pharmacol; 2000 Aug; 58(2):361-72. PubMed ID: 10908304
[TBL] [Abstract][Full Text] [Related]
4. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
Tirona RG; Lee W; Leake BF; Lan LB; Cline CB; Lamba V; Parviz F; Duncan SA; Inoue Y; Gonzalez FJ; Schuetz EG; Kim RB
Nat Med; 2003 Feb; 9(2):220-4. PubMed ID: 12514743
[TBL] [Abstract][Full Text] [Related]
5. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
[TBL] [Abstract][Full Text] [Related]
6. CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver.
Iwahori T; Matsuura T; Maehashi H; Sugo K; Saito M; Hosokawa M; Chiba K; Masaki T; Aizaki H; Ohkawa K; Suzuki T
Hepatology; 2003 Mar; 37(3):665-73. PubMed ID: 12601364
[TBL] [Abstract][Full Text] [Related]
7. The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
Song X; Xie M; Zhang H; Li Y; Sachdeva K; Yan B
Drug Metab Dispos; 2004 Jan; 32(1):35-42. PubMed ID: 14709618
[TBL] [Abstract][Full Text] [Related]
8. Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene.
Bombail V; Taylor K; Gibson GG; Plant N
Drug Metab Dispos; 2004 May; 32(5):525-35. PubMed ID: 15100175
[TBL] [Abstract][Full Text] [Related]
9. Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors.
Huss JM; Kasper CB
Mol Pharmacol; 2000 Jul; 58(1):48-57. PubMed ID: 10860926
[TBL] [Abstract][Full Text] [Related]
10. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.
Goodwin B; Hodgson E; Liddle C
Mol Pharmacol; 1999 Dec; 56(6):1329-39. PubMed ID: 10570062
[TBL] [Abstract][Full Text] [Related]
11. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S; Kurose K; Saito Y; Ozawa S; Hasegawa R; Komamura K; Ueno K; Kamakura S; Kitakaze M; Nakajima T; Matsumoto K; Akasawa A; Saito H; Sawada J
Drug Metab Dispos; 2004 Jan; 32(1):149-54. PubMed ID: 14709632
[TBL] [Abstract][Full Text] [Related]
12. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
Faucette SR; Sueyoshi T; Smith CM; Negishi M; Lecluyse EL; Wang H
J Pharmacol Exp Ther; 2006 Jun; 317(3):1200-9. PubMed ID: 16513849
[TBL] [Abstract][Full Text] [Related]
13. In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors.
Zhang W; Purchio A; Chen K; Burns SM; Contag CH; Contag PR
Biochem Pharmacol; 2003 Jun; 65(11):1889-96. PubMed ID: 12781341
[TBL] [Abstract][Full Text] [Related]
14. The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion.
Masuyama H; Suwaki N; Tateishi Y; Nakatsukasa H; Segawa T; Hiramatsu Y
Mol Endocrinol; 2005 May; 19(5):1170-80. PubMed ID: 15650019
[TBL] [Abstract][Full Text] [Related]
15. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
Chang HY; Chen CJ; Ma WC; Cheng WK; Lin YN; Lee YR; Chen JJ; Lim YP
Phytomedicine; 2017 Dec; 36():37-49. PubMed ID: 29157826
[TBL] [Abstract][Full Text] [Related]
16. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression.
Cooper BW; Cho TM; Thompson PM; Wallace AD
Toxicol Sci; 2008 Jun; 103(2):268-77. PubMed ID: 18332045
[TBL] [Abstract][Full Text] [Related]
17. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
Liu FJ; Song X; Yang D; Deng R; Yan B
Biochem J; 2008 Jan; 409(1):243-50. PubMed ID: 17764444
[TBL] [Abstract][Full Text] [Related]
18. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
Luo G; Cunningham M; Kim S; Burn T; Lin J; Sinz M; Hamilton G; Rizzo C; Jolley S; Gilbert D; Downey A; Mudra D; Graham R; Carroll K; Xie J; Madan A; Parkinson A; Christ D; Selling B; LeCluyse E; Gan LS
Drug Metab Dispos; 2002 Jul; 30(7):795-804. PubMed ID: 12065438
[TBL] [Abstract][Full Text] [Related]
19. Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
Lim YP; Huang JD
Pharmacogenet Genomics; 2007 May; 17(5):369-82. PubMed ID: 17429319
[TBL] [Abstract][Full Text] [Related]
20. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.
Pascussi JM; Drocourt L; Gerbal-Chaloin S; Fabre JM; Maurel P; Vilarem MJ
Eur J Biochem; 2001 Dec; 268(24):6346-58. PubMed ID: 11737189
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
