136 related articles for article (PubMed ID: 12170777)
1. Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms.
Qiao L; Yacoub A; McKinstry R; Park JS; Caron R; Fisher PB; Hagan MP; Grant S; Dent P
Cancer Biol Ther; 2002; 1(2):168-76. PubMed ID: 12170777
[TBL] [Abstract][Full Text] [Related]
2. Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
McKinstry R; Qiao L; Yacoub A; Dai Y; Decker R; Holt S; Hagan MP; Grant S; Dent P
Cancer Biol Ther; 2002; 1(3):243-53. PubMed ID: 12432271
[TBL] [Abstract][Full Text] [Related]
3. Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.
Park JS; Carter S; Reardon DB; Schmidt-Ullrich R; Dent P; Fisher PB
Mol Biol Cell; 1999 Dec; 10(12):4231-46. PubMed ID: 10588655
[TBL] [Abstract][Full Text] [Related]
4. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
Yu C; Krystal G; Varticovksi L; McKinstry R; Rahmani M; Dent P; Grant S
Cancer Res; 2002 Jan; 62(1):188-99. PubMed ID: 11782377
[TBL] [Abstract][Full Text] [Related]
5. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.
Dent P; Reardon DB; Park JS; Bowers G; Logsdon C; Valerie K; Schmidt-Ullrich R
Mol Biol Cell; 1999 Aug; 10(8):2493-506. PubMed ID: 10436007
[TBL] [Abstract][Full Text] [Related]
6. MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
Yacoub A; Mitchell C; Hong Y; Gopalkrishnan RV; Su ZZ; Gupta P; Sauane M; Lebedeva IV; Curiel DT; Mahasreshti PJ; Rosenfeld MR; Broaddus WC; James CD; Grant S; Fisher PB; Dent P
Cancer Biol Ther; 2004 Aug; 3(8):739-51. PubMed ID: 15197348
[TBL] [Abstract][Full Text] [Related]
7. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
Brassard DL; English JM; Malkowski M; Kirschmeier P; Nagabhushan TL; Bishop WR
Exp Cell Res; 2002 Feb; 273(2):138-46. PubMed ID: 11822869
[TBL] [Abstract][Full Text] [Related]
8. MEK1/2 inhibitors promote Ara-C-induced apoptosis but not loss of Deltapsi(m) in HL-60 cells.
Yu C; Wang Z; Dent P; Grant S
Biochem Biophys Res Commun; 2001 Sep; 286(5):1011-8. PubMed ID: 11527401
[TBL] [Abstract][Full Text] [Related]
9. Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.
Dai Y; Landowski TH; Rosen ST; Dent P; Grant S
Blood; 2002 Nov; 100(9):3333-43. PubMed ID: 12384435
[TBL] [Abstract][Full Text] [Related]
10. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
Qiao L; Studer E; Leach K; McKinstry R; Gupta S; Decker R; Kukreja R; Valerie K; Nagarkatti P; El Deiry W; Molkentin J; Schmidt-Ullrich R; Fisher PB; Grant S; Hylemon PB; Dent P
Mol Biol Cell; 2001 Sep; 12(9):2629-45. PubMed ID: 11553704
[TBL] [Abstract][Full Text] [Related]
11. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.
Tyagi A; Agarwal R; Agarwal C
Oncogene; 2003 Mar; 22(9):1302-16. PubMed ID: 12618755
[TBL] [Abstract][Full Text] [Related]
12. Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
Dai Y; Yu C; Singh V; Tang L; Wang Z; McInistry R; Dent P; Grant S
Cancer Res; 2001 Jul; 61(13):5106-15. PubMed ID: 11431348
[TBL] [Abstract][Full Text] [Related]
13. Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest.
Hagan M; Wang L; Hanley JR; Park JS; Dent P
Radiat Res; 2000 Apr; 153(4):371-83. PubMed ID: 10760996
[TBL] [Abstract][Full Text] [Related]
14. Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.
Yu C; Wang S; Dent P; Grant S
Mol Pharmacol; 2001 Jul; 60(1):143-54. PubMed ID: 11408609
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
Carter S; Auer KL; Reardon DB; Birrer M; Fisher PB; Valerie K; Schmidt-Ullrich R; Mikkelsen R; Dent P
Oncogene; 1998 May; 16(21):2787-96. PubMed ID: 9652746
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway.
Cartee L; Vrana JA; Wang Z; Park JS; Birrer M; Fisher PB; Grant S; Dent P
Int J Oncol; 2000 Feb; 16(2):413-22. PubMed ID: 10639586
[TBL] [Abstract][Full Text] [Related]
17. Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways.
Kamiguti AS; Harris RJ; Slupsky JR; Baker PK; Cawley JC; Zuzel M
Oncogene; 2003 Apr; 22(15):2272-84. PubMed ID: 12700663
[TBL] [Abstract][Full Text] [Related]
18. MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.
Yacoub A; Gilfor D; Hawkins W; Park MA; Hanna D; Hagan MP; Curiel DT; Fisher PB; Grant S; Dent P
Cancer Biol Ther; 2006 Oct; 5(10):1332-9. PubMed ID: 16957420
[TBL] [Abstract][Full Text] [Related]
19. Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.
Pelletier JP; Fernandes JC; Jovanovic DV; Reboul P; Martel-Pelletier J
J Rheumatol; 2001 Nov; 28(11):2509-19. PubMed ID: 11708426
[TBL] [Abstract][Full Text] [Related]
20. Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.
Yu C; Dai Y; Dent P; Grant S
Cancer Biol Ther; 2002; 1(6):674-82. PubMed ID: 12642693
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
