182 related articles for article (PubMed ID: 12171933)
1. Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
Williams SJ; Mark BL; Vocadlo DJ; James MN; Withers SG
J Biol Chem; 2002 Oct; 277(42):40055-65. PubMed ID: 12171933
[TBL] [Abstract][Full Text] [Related]
2. Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
Mark BL; Vocadlo DJ; Knapp S; Triggs-Raine BL; Withers SG; James MN
J Biol Chem; 2001 Mar; 276(13):10330-7. PubMed ID: 11124970
[TBL] [Abstract][Full Text] [Related]
3. Structural and functional characterization of Streptomyces plicatus beta-N-acetylhexosaminidase by comparative molecular modeling and site-directed mutagenesis.
Mark BL; Wasney GA; Salo TJ; Khan AR; Cao Z; Robbins PW; James MN; Triggs-Raine BL
J Biol Chem; 1998 Jul; 273(31):19618-24. PubMed ID: 9677388
[TBL] [Abstract][Full Text] [Related]
4. Elucidating the nature of the Streptomyces plicatus beta-hexosaminidase-bound intermediate using ab initio molecular dynamics simulations.
Greig IR; Zahariev F; Withers SG
J Am Chem Soc; 2008 Dec; 130(51):17620-8. PubMed ID: 19053474
[TBL] [Abstract][Full Text] [Related]
5. Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.
Cetinbaş N; Macauley MS; Stubbs KA; Drapala R; Vocadlo DJ
Biochemistry; 2006 Mar; 45(11):3835-44. PubMed ID: 16533067
[TBL] [Abstract][Full Text] [Related]
6. Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a β-N-acetylhexosaminidase in Akkermansia muciniphila.
Chen X; Li M; Wang Y; Tang R; Zhang M
Biochem Biophys Res Commun; 2019 Sep; 517(1):29-35. PubMed ID: 31345574
[TBL] [Abstract][Full Text] [Related]
7. Role of active-site residues of dispersin B, a biofilm-releasing beta-hexosaminidase from a periodontal pathogen, in substrate hydrolysis.
Manuel SG; Ragunath C; Sait HB; Izano EA; Kaplan JB; Ramasubbu N
FEBS J; 2007 Nov; 274(22):5987-99. PubMed ID: 17949435
[TBL] [Abstract][Full Text] [Related]
8. Detailed comparative analysis of the catalytic mechanisms of beta-N-acetylglucosaminidases from families 3 and 20 of glycoside hydrolases.
Vocadlo DJ; Withers SG
Biochemistry; 2005 Sep; 44(38):12809-18. PubMed ID: 16171396
[TBL] [Abstract][Full Text] [Related]
9. Mechanism of the family 1 beta-glucosidase from Streptomyces sp: catalytic residues and kinetic studies.
Vallmitjana M; Ferrer-Navarro M; Planell R; Abel M; Ausín C; Querol E; Planas A; Pérez-Pons JA
Biochemistry; 2001 May; 40(20):5975-82. PubMed ID: 11352732
[TBL] [Abstract][Full Text] [Related]
10. Structural and kinetic analysis of Bacillus subtilis N-acetylglucosaminidase reveals a unique Asp-His dyad mechanism.
Litzinger S; Fischer S; Polzer P; Diederichs K; Welte W; Mayer C
J Biol Chem; 2010 Nov; 285(46):35675-84. PubMed ID: 20826810
[TBL] [Abstract][Full Text] [Related]
11. Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases.
Liu T; Zhang H; Liu F; Chen L; Shen X; Yang Q
Biochem J; 2011 Sep; 438(3):467-74. PubMed ID: 21692744
[TBL] [Abstract][Full Text] [Related]
12. Structure and activity of the Streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition.
Thi NN; Offen WA; Shareck F; Davies GJ; Doucet N
Biochemistry; 2014 Mar; 53(11):1789-800. PubMed ID: 24559145
[TBL] [Abstract][Full Text] [Related]
13. Structures of chitobiase mutants complexed with the substrate Di-N-acetyl-d-glucosamine: the catalytic role of the conserved acidic pair, aspartate 539 and glutamate 540.
Prag G; Papanikolau Y; Tavlas G; Vorgias CE; Petratos K; Oppenheim AB
J Mol Biol; 2000 Jul; 300(3):611-7. PubMed ID: 10884356
[TBL] [Abstract][Full Text] [Related]
14. The structure of an allosamidin complex with the Coccidioides immitis chitinase defines a role for a second acid residue in substrate-assisted mechanism.
Bortone K; Monzingo AF; Ernst S; Robertus JD
J Mol Biol; 2002 Jul; 320(2):293-302. PubMed ID: 12079386
[TBL] [Abstract][Full Text] [Related]
15. De novo design of a trans-β-N-acetylglucosaminidase activity from a GH1 β-glycosidase by mechanism engineering.
André-Miral C; Koné FM; Solleux C; Grandjean C; Dion M; Tran V; Tellier C
Glycobiology; 2015 Apr; 25(4):394-402. PubMed ID: 25378480
[TBL] [Abstract][Full Text] [Related]
16. High resolution structural analyses of mutant chitinase A complexes with substrates provide new insight into the mechanism of catalysis.
Papanikolau Y; Prag G; Tavlas G; Vorgias CE; Oppenheim AB; Petratos K
Biochemistry; 2001 Sep; 40(38):11338-43. PubMed ID: 11560481
[TBL] [Abstract][Full Text] [Related]
17. A case for reverse protonation: identification of Glu160 as an acid/base catalyst in Thermoanaerobacterium saccharolyticum beta-xylosidase and detailed kinetic analysis of a site-directed mutant.
Vocadlo DJ; Wicki J; Rupitz K; Withers SG
Biochemistry; 2002 Aug; 41(31):9736-46. PubMed ID: 12146939
[TBL] [Abstract][Full Text] [Related]
18. Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis.
Jedrzejas MJ; Stern R
Proteins; 2005 Nov; 61(2):227-38. PubMed ID: 16104017
[TBL] [Abstract][Full Text] [Related]
19. Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
Mark BL; Vocadlo DJ; Zhao D; Knapp S; Withers SG; James MN
J Biol Chem; 2001 Nov; 276(45):42131-7. PubMed ID: 11522797
[TBL] [Abstract][Full Text] [Related]
20. Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B.
Hou Y; Vocadlo DJ; Leung A; Withers SG; Mahuran D
Biochemistry; 2001 Feb; 40(7):2201-9. PubMed ID: 11329289
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
