BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

424 related articles for article (PubMed ID: 12172555)

  • 1. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
    Gao X; Zhang Y; Arrazola P; Hino O; Kobayashi T; Yeung RS; Ru B; Pan D
    Nat Cell Biol; 2002 Sep; 4(9):699-704. PubMed ID: 12172555
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.
    Nobukini T; Thomas G
    Novartis Found Symp; 2004; 262():148-54; discussion 154-9, 265-8. PubMed ID: 15562827
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
    Stocker H; Radimerski T; Schindelholz B; Wittwer F; Belawat P; Daram P; Breuer S; Thomas G; Hafen E
    Nat Cell Biol; 2003 Jun; 5(6):559-65. PubMed ID: 12766775
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
    Zhang Y; Gao X; Saucedo LJ; Ru B; Edgar BA; Pan D
    Nat Cell Biol; 2003 Jun; 5(6):578-81. PubMed ID: 12771962
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.
    Jaeschke A; Hartkamp J; Saitoh M; Roworth W; Nobukuni T; Hodges A; Sampson J; Thomas G; Lamb R
    J Cell Biol; 2002 Oct; 159(2):217-24. PubMed ID: 12403809
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase.
    Avruch J; Hara K; Lin Y; Liu M; Long X; Ortiz-Vega S; Yonezawa K
    Oncogene; 2006 Oct; 25(48):6361-72. PubMed ID: 17041622
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Rheb promotes cell growth as a component of the insulin/TOR signalling network.
    Saucedo LJ; Gao X; Chiarelli DA; Li L; Pan D; Edgar BA
    Nat Cell Biol; 2003 Jun; 5(6):566-71. PubMed ID: 12766776
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.
    Schmidt A; Beck T; Koller A; Kunz J; Hall MN
    EMBO J; 1998 Dec; 17(23):6924-31. PubMed ID: 9843498
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.
    Sun P; Quan Z; Zhang B; Wu T; Xi R
    Development; 2010 Aug; 137(15):2461-9. PubMed ID: 20573703
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.
    Fingar DC; Blenis J
    Oncogene; 2004 Apr; 23(18):3151-71. PubMed ID: 15094765
    [TBL] [Abstract][Full Text] [Related]  

  • 11. L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport.
    Peyrollier K; Hajduch E; Blair AS; Hyde R; Hundal HS
    Biochem J; 2000 Sep; 350 Pt 2(Pt 2):361-8. PubMed ID: 10947949
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.
    Nellist M; Burgers PC; van den Ouweland AM; Halley DJ; Luider TM
    Biochem Biophys Res Commun; 2005 Aug; 333(3):818-26. PubMed ID: 15963462
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.
    Weisman R; Roitburg I; Schonbrun M; Harari R; Kupiec M
    Genetics; 2007 Mar; 175(3):1153-62. PubMed ID: 17179073
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models.
    Lee L; Sudentas P; Donohue B; Asrican K; Worku A; Walker V; Sun Y; Schmidt K; Albert MS; El-Hashemite N; Lader AS; Onda H; Zhang H; Kwiatkowski DJ; Dabora SL
    Genes Chromosomes Cancer; 2005 Mar; 42(3):213-27. PubMed ID: 15578690
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin.
    El-Hashemite N; Walker V; Zhang H; Kwiatkowski DJ
    Cancer Res; 2003 Sep; 63(17):5173-7. PubMed ID: 14500340
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
    Ma L; Chen Z; Erdjument-Bromage H; Tempst P; Pandolfi PP
    Cell; 2005 Apr; 121(2):179-93. PubMed ID: 15851026
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
    Uhlmann EJ; Apicelli AJ; Baldwin RL; Burke SP; Bajenaru ML; Onda H; Kwiatkowski D; Gutmann DH
    Oncogene; 2002 Jun; 21(25):4050-9. PubMed ID: 12037687
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Rheb activation of mTOR and S6K1 signaling.
    Hanrahan J; Blenis J
    Methods Enzymol; 2006; 407():542-55. PubMed ID: 16757352
    [TBL] [Abstract][Full Text] [Related]  

  • 19. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
    Inoki K; Li Y; Zhu T; Wu J; Guan KL
    Nat Cell Biol; 2002 Sep; 4(9):648-57. PubMed ID: 12172553
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.
    Chan JA; Zhang H; Roberts PS; Jozwiak S; Wieslawa G; Lewin-Kowalik J; Kotulska K; Kwiatkowski DJ
    J Neuropathol Exp Neurol; 2004 Dec; 63(12):1236-42. PubMed ID: 15624760
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.