198 related articles for article (PubMed ID: 12175242)
1. Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.
Biswas K; Lin H; Njardarson JT; Chappell MD; Chou TC; Guan Y; Tong WP; He L; Horwitz SB; Danishefsky SJ
J Am Chem Soc; 2002 Aug; 124(33):9825-32. PubMed ID: 12175242
[TBL] [Abstract][Full Text] [Related]
2. Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series.
Rivkin A; Njardarson JT; Biswas K; Chou TC; Danishefsky SJ
J Org Chem; 2002 Nov; 67(22):7737-40. PubMed ID: 12398497
[TBL] [Abstract][Full Text] [Related]
3. Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D.
White JD; Carter RG; Sundermann KF; Wartmann M
J Am Chem Soc; 2001 Jun; 123(23):5407-13. PubMed ID: 11389619
[TBL] [Abstract][Full Text] [Related]
4. Synthesis of epothilone analogues by antibody-catalyzed resolution of thiazole aldol synthons on a multigram scale. Biological consequences of C-13 alkylation of epothilones.
Sinha SC; Sun J; Wartmann M; Lerner RA
Chembiochem; 2001 Sep; 2(9):656-65. PubMed ID: 11828502
[TBL] [Abstract][Full Text] [Related]
5. On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones.
Stachel SJ; Lee CB; Spassova M; Chappell MD; Bornmann WG; Danishefsky SJ; Chou TC; Guan Y
J Org Chem; 2001 Jun; 66(12):4369-78. PubMed ID: 11397179
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of highly potent analogues of epothilones B and D.
Altmann KH; Bold G; Caravatti G; Flörsheimer A; Guagnano V; Wartmann M
Bioorg Med Chem Lett; 2000 Dec; 10(24):2765-8. PubMed ID: 11133086
[TBL] [Abstract][Full Text] [Related]
7. Total synthesis of 12,13-desoxyepothilone B (Epothilone D).
Broadrup RL; Sundar HM; Swindell CS
Bioorg Chem; 2005 Apr; 33(2):116-33. PubMed ID: 15788167
[TBL] [Abstract][Full Text] [Related]
8. Chemical synthesis and biological properties of pyridine epothilones.
Nicolaou KC; Scarpelli R; Bollbuck B; Werschkun B; Pereira MM; Wartmann M; Altmann KH; Zaharevitz D; Gussio R; Giannakakou P
Chem Biol; 2000 Aug; 7(8):593-9. PubMed ID: 11048950
[TBL] [Abstract][Full Text] [Related]
9. Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21.
Lee CB; Chou TC; Zhang XG; Wang ZG; Kuduk SD; Chappell MD; Stachel SJ; Danishefsky SJ
J Org Chem; 2000 Oct; 65(20):6525-33. PubMed ID: 11052097
[TBL] [Abstract][Full Text] [Related]
10. Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.
Nicolaou KC; Hepworth D; King NP; Finlay MR; Scarpelli R; Pereira MM; Bollbuck B; Bigot A; Werschkun B; Winssinger N
Chemistry; 2000 Aug; 6(15):2783-800. PubMed ID: 10985727
[TBL] [Abstract][Full Text] [Related]
11. Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.
Nicolaou KC; King NP; Finlay MR; He Y; Roschangar F; Vourloumis D; Vallberg H; Sarabia F; Ninkovic S; Hepworth D
Bioorg Med Chem; 1999 May; 7(5):665-97. PubMed ID: 10400321
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of epothilones A and B in solid and solution phase.
Nicolaou KC; Winssinger N; Pastor J; Ninkovic S; Sarabia F; He Y; Vourloumis D; Yang Z; Li T; Giannakakou P; Hamel E
Nature; 1997 May; 387(6630):268-72. PubMed ID: 9153390
[TBL] [Abstract][Full Text] [Related]
13. On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments.
Stachel SJ; Chappell MD; Lee CB; Danishefsky SJ; Chou TC; He L; Horwitz SB
Org Lett; 2000 Jun; 2(11):1637-9. PubMed ID: 10841498
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, structure proof, and biological activity of epothilone cyclopropanes.
Johnson J; Kim SH; Bifano M; DiMarco J; Fairchild C; Gougoutas J; Lee F; Long B; Tokarski J; Vite G
Org Lett; 2000 Jun; 2(11):1537-40. PubMed ID: 10841473
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and biological evaluation of artificial macrosphelides in the search for new apoptosis-inducing agents.
Matsuya Y; Kobayashi Y; Kawaguchi T; Hori A; Watanabe Y; Ishihara K; Ahmed K; Wei ZL; Yu DY; Zhao QL; Kondo T; Nemoto H
Chemistry; 2009 Jun; 15(23):5799-813. PubMed ID: 19370747
[TBL] [Abstract][Full Text] [Related]
16. Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity.
Kuzniewski CN; Gertsch J; Wartmann M; Altmann KH
Org Lett; 2008 Mar; 10(6):1183-6. PubMed ID: 18303900
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones.
Nicolaou KC; Finlay MR; Ninkovic S; King NP; He Y; Li T; Sarabia F; Vourloumis D
Chem Biol; 1998 Jul; 5(7):365-72. PubMed ID: 9662505
[TBL] [Abstract][Full Text] [Related]
18. Total synthesis of epothilone A.
Zhu B; Panek JS
Org Lett; 2000 Aug; 2(17):2575-8. PubMed ID: 10990400
[TBL] [Abstract][Full Text] [Related]
19. Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F.
Lee CB; Wu Z; Zhang F; Chappell MD; Stachel SJ; Chou TC; Guan Y; Danishefsky SJ
J Am Chem Soc; 2001 Jun; 123(22):5249-59. PubMed ID: 11457387
[TBL] [Abstract][Full Text] [Related]
20. Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.
Rivkin A; Yoshimura F; Gabarda AE; Chou TC; Dong H; Tong WP; Danishefsky SJ
J Am Chem Soc; 2003 Mar; 125(10):2899-901. PubMed ID: 12617656
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
