These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 12176984)

  • 1. Identification and characterization of the interaction between tuberin and 14-3-3zeta.
    Nellist M; Goedbloed MA; de Winter C; Verhaaf B; Jankie A; Reuser AJ; van den Ouweland AM; van der Sluijs P; Halley DJ
    J Biol Chem; 2002 Oct; 277(42):39417-24. PubMed ID: 12176984
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin.
    Hodges AK; Li S; Maynard J; Parry L; Braverman R; Cheadle JP; DeClue JE; Sampson JR
    Hum Mol Genet; 2001 Dec; 10(25):2899-905. PubMed ID: 11741833
    [TBL] [Abstract][Full Text] [Related]  

  • 3. TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex.
    Nellist M; Verhaaf B; Goedbloed MA; Reuser AJ; van den Ouweland AM; Halley DJ
    Hum Mol Genet; 2001 Dec; 10(25):2889-98. PubMed ID: 11741832
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.
    Aicher LD; Campbell JS; Yeung RS
    J Biol Chem; 2001 Jun; 276(24):21017-21. PubMed ID: 11290735
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.
    van Slegtenhorst M; Nellist M; Nagelkerken B; Cheadle J; Snell R; van den Ouweland A; Reuser A; Sampson J; Halley D; van der Sluijs P
    Hum Mol Genet; 1998 Jun; 7(6):1053-7. PubMed ID: 9580671
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin.
    Nellist M; van Slegtenhorst MA; Goedbloed M; van den Ouweland AM; Halley DJ; van der Sluijs P
    J Biol Chem; 1999 Dec; 274(50):35647-52. PubMed ID: 10585443
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
    Shumway SD; Li Y; Xiong Y
    J Biol Chem; 2003 Jan; 278(4):2089-92. PubMed ID: 12468542
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regulation of tuberous sclerosis complex (TSC) function by 14-3-3 proteins.
    Nellist M; Goedbloed MA; Halley DJ
    Biochem Soc Trans; 2003 Jun; 31(Pt 3):587-91. PubMed ID: 12773161
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
    Roux PP; Ballif BA; Anjum R; Gygi SP; Blenis J
    Proc Natl Acad Sci U S A; 2004 Sep; 101(37):13489-94. PubMed ID: 15342917
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin.
    Tee AR; Anjum R; Blenis J
    J Biol Chem; 2003 Sep; 278(39):37288-96. PubMed ID: 12867426
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.
    Murthy V; Han S; Beauchamp RL; Smith N; Haddad LA; Ito N; Ramesh V
    J Biol Chem; 2004 Jan; 279(2):1351-8. PubMed ID: 14559897
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.
    Astrinidis A; Senapedis W; Coleman TR; Henske EP
    J Biol Chem; 2003 Dec; 278(51):51372-9. PubMed ID: 14551205
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.
    Dan HC; Sun M; Yang L; Feldman RI; Sui XM; Ou CC; Nellist M; Yeung RS; Halley DJ; Nicosia SV; Pledger WJ; Cheng JQ
    J Biol Chem; 2002 Sep; 277(38):35364-70. PubMed ID: 12167664
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
    Li Y; Inoki K; Vacratsis P; Guan KL
    J Biol Chem; 2003 Apr; 278(16):13663-71. PubMed ID: 12582162
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential localization of hamartin and tuberin and increased S6 phosphorylation in a tuber.
    Jansen FE; Notenboom RG; Nellist M; Goedbloed MA; Halley DJ; de Graan PN; van Nieuwenhuizen O
    Neurology; 2004 Oct; 63(7):1293-5. PubMed ID: 15477556
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tumour suppressors hamartin and tuberin: intracellular signalling.
    Krymskaya VP
    Cell Signal; 2003 Aug; 15(8):729-39. PubMed ID: 12781866
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.
    Rosner M; Hengstschläger M
    J Biol Chem; 2004 Nov; 279(47):48707-15. PubMed ID: 15355997
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
    Karbowniczek M; Cash T; Cheung M; Robertson GP; Astrinidis A; Henske EP
    J Biol Chem; 2004 Jul; 279(29):29930-7. PubMed ID: 15150271
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The tuberin-hamartin complex negatively regulates beta-catenin signaling activity.
    Mak BC; Takemaru K; Kenerson HL; Moon RT; Yeung RS
    J Biol Chem; 2003 Feb; 278(8):5947-51. PubMed ID: 12511557
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination.
    Benvenuto G; Li S; Brown SJ; Braverman R; Vass WC; Cheadle JP; Halley DJ; Sampson JR; Wienecke R; DeClue JE
    Oncogene; 2000 Dec; 19(54):6306-16. PubMed ID: 11175345
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.