283 related articles for article (PubMed ID: 12181740)
1. Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.
Brognard J; Dennis PA
Cell Death Differ; 2002 Sep; 9(9):893-904. PubMed ID: 12181740
[TBL] [Abstract][Full Text] [Related]
2. Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines.
Miranda MB; McGuire TF; Johnson DE
Leukemia; 2002 Apr; 16(4):683-92. PubMed ID: 11960350
[TBL] [Abstract][Full Text] [Related]
3. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Brognard J; Clark AS; Ni Y; Dennis PA
Cancer Res; 2001 May; 61(10):3986-97. PubMed ID: 11358816
[TBL] [Abstract][Full Text] [Related]
4. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
Yu C; Krystal G; Varticovksi L; McKinstry R; Rahmani M; Dent P; Grant S
Cancer Res; 2002 Jan; 62(1):188-99. PubMed ID: 11782377
[TBL] [Abstract][Full Text] [Related]
5. Interferon-alpha2b reduces phosphorylation and activity of MEK and ERK through a Ras/Raf-independent mechanism.
Romerio F; Riva A; Zella D
Br J Cancer; 2000 Aug; 83(4):532-8. PubMed ID: 10945503
[TBL] [Abstract][Full Text] [Related]
6. Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines.
Woessmann W; Chen X; Borkhardt A
Cancer Chemother Pharmacol; 2002 Nov; 50(5):397-404. PubMed ID: 12439598
[TBL] [Abstract][Full Text] [Related]
7. Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.
Yang R; Piperdi S; Gorlick R
Clin Cancer Res; 2008 Oct; 14(20):6396-404. PubMed ID: 18927278
[TBL] [Abstract][Full Text] [Related]
8. Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals.
von Gise A; Lorenz P; Wellbrock C; Hemmings B; Berberich-Siebelt F; Rapp UR; Troppmair J
Mol Cell Biol; 2001 Apr; 21(7):2324-36. PubMed ID: 11259582
[TBL] [Abstract][Full Text] [Related]
9. Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.
Yip-Schneider MT; Klein PJ; Wentz SC; Zeni A; Menze A; Schmidt CM
J Pharmacol Exp Ther; 2009 Jun; 329(3):1063-70. PubMed ID: 19258520
[TBL] [Abstract][Full Text] [Related]
10. Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways.
Kamiguti AS; Harris RJ; Slupsky JR; Baker PK; Cawley JC; Zuzel M
Oncogene; 2003 Apr; 22(15):2272-84. PubMed ID: 12700663
[TBL] [Abstract][Full Text] [Related]
11. Prolonged extracellular signal-regulated kinase 1/2 activation during fibroblast growth factor 1- or heregulin beta1-induced antiestrogen-resistant growth of breast cancer cells is resistant to mitogen-activated protein/extracellular regulated kinase kinase inhibitors.
Thottassery JV; Sun Y; Westbrook L; Rentz SS; Manuvakhova M; Qu Z; Samuel S; Upshaw R; Cunningham A; Kern FG
Cancer Res; 2004 Jul; 64(13):4637-47. PubMed ID: 15231676
[TBL] [Abstract][Full Text] [Related]
12. cAMP inhibits the proliferation of retinal pigmented epithelial cells through the inhibition of ERK1/2 in a PKA-independent manner.
Hecquet C; Lefevre G; Valtink M; Engelmann K; Mascarelli F
Oncogene; 2002 Sep; 21(39):6101-12. PubMed ID: 12203122
[TBL] [Abstract][Full Text] [Related]
13. Unbalanced activation of ERK1/2 and MEK1/2 in apigenin-induced HeLa cell death.
Llorens F; Miró FA; Casañas A; Roher N; Garcia L; Plana M; Gómez N; Itarte E
Exp Cell Res; 2004 Sep; 299(1):15-26. PubMed ID: 15302569
[TBL] [Abstract][Full Text] [Related]
14. Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma.
Wiesenauer CA; Yip-Schneider MT; Wang Y; Schmidt CM
J Am Coll Surg; 2004 Mar; 198(3):410-21. PubMed ID: 14992744
[TBL] [Abstract][Full Text] [Related]
15. Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.
Wen-Sheng W
Cancer Lett; 2006 Jul; 239(1):27-35. PubMed ID: 16169661
[TBL] [Abstract][Full Text] [Related]
16. Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.
MacKeigan JP; Taxman DJ; Hunter D; Earp HS; Graves LM; Ting JP
Clin Cancer Res; 2002 Jul; 8(7):2091-9. PubMed ID: 12114408
[TBL] [Abstract][Full Text] [Related]
17. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
Blalock WL; Navolanic PM; Steelman LS; Shelton JG; Moye PW; Lee JT; Franklin RA; Mirza A; McMahon M; White MK; McCubrey JA
Leukemia; 2003 Jun; 17(6):1058-67. PubMed ID: 12764369
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
Tsurutani J; West KA; Sayyah J; Gills JJ; Dennis PA
Cancer Res; 2005 Sep; 65(18):8423-32. PubMed ID: 16166321
[TBL] [Abstract][Full Text] [Related]
19. The kinase domain of MEKK1 induces apoptosis by dysregulation of MAP kinase pathways.
Boldt S; Weidle UH; Kolch W
Exp Cell Res; 2003 Feb; 283(1):80-90. PubMed ID: 12565821
[TBL] [Abstract][Full Text] [Related]
20. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium.
Chuang SM; Wang IC; Yang JL
Carcinogenesis; 2000 Jul; 21(7):1423-32. PubMed ID: 10874022
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
