BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 12188033)

  • 21. BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor.
    Wada Y; Yagihashi A; Terasawa K; Miyao N; Hirata K; Cicciarelli J; Iwaki Y
    Artif Organs; 1996 Aug; 20(8):849-52. PubMed ID: 8853794
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2'-deoxyguanosine in primates.
    Kilpatrick JM; Morris PE; Serota DG; Phillips D; Moore DR; Bennett JC; Babu YS
    Int Immunopharmacol; 2003 Apr; 3(4):541-8. PubMed ID: 12689658
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells.
    Elstein KH; Mole ML; Setzer RW; Zucker RM; Kavlock RJ; Rogers JM; Lau C
    Toxicol Appl Pharmacol; 1997 Sep; 146(1):29-39. PubMed ID: 9299594
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor.
    Gilbertsen RB; Dong MK; Wilburn DJ; Kossarek LM; Sircar JC; Kostlan CR; Conroy MC
    Adv Exp Med Biol; 1991; 309A():41-4. PubMed ID: 1789255
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Functional and mechanistic studies on the toxicity of deoxyguanosine for the in vitro proliferation and differentiation of human peripheral blood B lymphocytes.
    Scharenberg JG; Spaapen LJ; Rijkers GT; Duran M; Staal GE; Zegers BJ
    Eur J Immunol; 1986 Apr; 16(4):381-7. PubMed ID: 3084280
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of purine-nucleoside phosphorylase deficiency.
    Albert D; Bluestein HG; Willis RC; Nette K; Seegmiller JE
    Cell Immunol; 1984 Jul; 86(2):501-9. PubMed ID: 6428752
    [TBL] [Abstract][Full Text] [Related]  

  • 27. SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
    Davenne T; Klintman J; Sharma S; Rigby RE; Blest HTW; Cursi C; Bridgeman A; Dadonaite B; De Keersmaecker K; Hillmen P; Chabes A; Schuh A; Rehwinkel J
    Cell Rep; 2020 May; 31(6):107640. PubMed ID: 32402273
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Different pathways for deoxyguanosine toxicity in T-lymphocytes of various developmental stages.
    Scharenberg JG; Rijkers GT; Spaapen LJ; Toebes EA; Rijksen G; Duran M; Staal GE; Zegers BJ
    Int J Immunopharmacol; 1988; 10(6):675-86. PubMed ID: 2974022
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor.
    Gilbertsen RB; Scott ME; Dong MK; Kossarek LM; Bennett MK; Schrier DJ; Sircar JC
    Agents Actions; 1987 Aug; 21(3-4):272-4. PubMed ID: 3120507
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Synergistic inhibition of human leukemia cell growth by deoxyguanosine and 1-beta-D-arabinofuranosylcytosine.
    Akman SA; Ross DD; Joneckis CC; Fox BM; Bachur NR
    Biochem Pharmacol; 1984 Apr; 33(7):1059-63. PubMed ID: 6712715
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells.
    Posmantur R; Wang KK; Nath R; Gilbertsen RB
    Immunopharmacology; 1997 Oct; 37(2-3):231-44. PubMed ID: 9403342
    [TBL] [Abstract][Full Text] [Related]  

  • 32. The effect of deoxyguanosine on human lymphocyte function. II. Analysis of the interference with B lymphocyte differentiation in vitro.
    Spaapen LJ; Rijkers GT; Staal GE; Rijksen G; Duran M; Stoop JW; Zegers BJ
    J Immunol; 1984 May; 132(5):2318-23. PubMed ID: 6425400
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.
    Gilbertsen RB; Dong MK; Kossarek LM; Sircar JC; Kostlan CR; Conroy MC
    Biochem Biophys Res Commun; 1991 Aug; 178(3):1351-8. PubMed ID: 1908235
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Purine nucleoside phosphorylase inhibition as a novel therapeutic approach for B-cell lymphoid malignancies.
    Furman RR; Hoelzer D
    Semin Oncol; 2007 Dec; 34(6 Suppl 5):S29-34. PubMed ID: 18086344
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia.
    Balakrishnan K; Verma D; O'Brien S; Kilpatrick JM; Chen Y; Tyler BF; Bickel S; Bantia S; Keating MJ; Kantarjian H; Gandhi V; Ravandi F
    Blood; 2010 Aug; 116(6):886-92. PubMed ID: 20427701
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Deoxyribonucleoside triphosphate metabolism and the mammalian cell cycle. Effects of hydroxyurea on mutant and wild-type mouse S49 T-lymphoma cells.
    Eriksson S; Skog S; Tribukait B; Wallström B
    Exp Cell Res; 1987 Jan; 168(1):79-88. PubMed ID: 3096753
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts.
    Mann GJ; Fox RM
    J Clin Invest; 1986 Nov; 78(5):1261-9. PubMed ID: 3490493
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools.
    Darè E; Zhang LH; Jenssen D; Bianchi V
    J Mol Biol; 1995 Oct; 252(5):514-21. PubMed ID: 7563070
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Regulatory effects of deoxyribonucleosides on the activity of 5-methoxymethyl-2'-deoxycytidine: modulation of antiherpes activity by deoxyguanosine and tetrahydrodeoxyuridine.
    Aduma PJ; Gupta SV; Stuart AL; Tourigny G
    Antiviral Res; 1991 May; 15(4):301-13. PubMed ID: 1659312
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A model of human anti-T-cell monoclonal antibody therapy in SCID mice engrafted with human peripheral blood lymphocytes.
    Tsuchida M; Brown SA; Tutt LM; Tan J; Seehafer DL; Harris JP; Xun CQ; Thompson JS
    Clin Transplant; 1997 Oct; 11(5 Pt 2):522-8. PubMed ID: 9361954
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.