These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease. Pollack SJ; Lewis H Curr Opin Investig Drugs; 2005 Jan; 6(1):35-47. PubMed ID: 15675602 [TBL] [Abstract][Full Text] [Related]
3. Secretase as a target for Alzheimer's disease. Wolfe MS Curr Top Med Chem; 2002 Apr; 2(4):371-83. PubMed ID: 11966461 [TBL] [Abstract][Full Text] [Related]
4. gamma-Secretase inhibitors as molecular probes of presenilin function. Wolfe MS J Mol Neurosci; 2001 Oct; 17(2):199-204. PubMed ID: 11816793 [TBL] [Abstract][Full Text] [Related]
5. Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease. Beher D; Graham SL Expert Opin Investig Drugs; 2005 Nov; 14(11):1385-409. PubMed ID: 16255678 [TBL] [Abstract][Full Text] [Related]
6. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity. Shearman MS; Beher D; Clarke EE; Lewis HD; Harrison T; Hunt P; Nadin A; Smith AL; Stevenson G; Castro JL Biochemistry; 2000 Aug; 39(30):8698-704. PubMed ID: 10913280 [TBL] [Abstract][Full Text] [Related]
7. The search for gamma-secretase and development of inhibitors. Tsai JY; Wolfe MS; Xia W Curr Med Chem; 2002 Jun; 9(11):1087-106. PubMed ID: 12052174 [TBL] [Abstract][Full Text] [Related]
9. Secretases as therapeutic targets for the treatment of Alzheimer's disease. Dominguez DI; De Strooper B; Annaert W Amyloid; 2001 Jun; 8(2):124-42. PubMed ID: 11409035 [TBL] [Abstract][Full Text] [Related]
11. Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors. Moore CL; Diehl TS; Selkoe DJ; Wolfe MS Ann N Y Acad Sci; 2000; 920():197-205. PubMed ID: 11193150 [TBL] [Abstract][Full Text] [Related]
12. Gamma-secretase: a catalyst of Alzheimer disease and signal transduction. Li YM Mol Interv; 2001 Oct; 1(4):198-207. PubMed ID: 14993342 [TBL] [Abstract][Full Text] [Related]
13. The presenilins in Alzheimer's disease--proteolysis holds the key. Haass C; De Strooper B Science; 1999 Oct; 286(5441):916-9. PubMed ID: 10542139 [TBL] [Abstract][Full Text] [Related]
15. Gamma-secretase inhibitors and Alzheimer's disease. Roberts SB Adv Drug Deliv Rev; 2002 Dec; 54(12):1579-88. PubMed ID: 12453675 [TBL] [Abstract][Full Text] [Related]
16. gamma-Secretase as a target for drug intervention in Alzheimer's disease. Harrison T; Churcher I; Beher D Curr Opin Drug Discov Devel; 2004 Sep; 7(5):709-19. PubMed ID: 15503873 [TBL] [Abstract][Full Text] [Related]
18. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Wolfe MS; De Los Angeles J; Miller DD; Xia W; Selkoe DJ Biochemistry; 1999 Aug; 38(35):11223-30. PubMed ID: 10471271 [TBL] [Abstract][Full Text] [Related]
19. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. Campbell WA; Reed ML; Strahle J; Wolfe MS; Xia W J Neurochem; 2003 Jun; 85(6):1563-74. PubMed ID: 12787075 [TBL] [Abstract][Full Text] [Related]
20. Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease. Churcher I; Beher D Curr Pharm Des; 2005; 11(26):3363-82. PubMed ID: 16250842 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]