These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

250 related articles for article (PubMed ID: 12197664)

  • 1. Molecular docking studies of a group of hydroxamate inhibitors with gelatinase-A by molecular dynamics.
    Hou T; Zhang W; Xu X
    J Comput Aided Mol Des; 2002 Jan; 16(1):27-41. PubMed ID: 12197664
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Homology modeling of gelatinase catalytic domains and docking simulations of novel sulfonamide inhibitors.
    Kiyama R; Tamura Y; Watanabe F; Tsuzuki H; Ohtani M; Yodo M
    J Med Chem; 1999 May; 42(10):1723-38. PubMed ID: 10346925
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
    Yamamoto M; Tsujishita H; Hori N; Ohishi Y; Inoue S; Ikeda S; Okada Y
    J Med Chem; 1998 Apr; 41(8):1209-17. PubMed ID: 9548812
    [TBL] [Abstract][Full Text] [Related]  

  • 4. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
    Grams F; Reinemer P; Powers JC; Kleine T; Pieper M; Tschesche H; Huber R; Bode W
    Eur J Biochem; 1995 Mar; 228(3):830-41. PubMed ID: 7737183
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.
    Jacobson IC; Reddy PG; Wasserman ZR; Hardman KD; Covington MB; Arner EC; Copeland RA; Decicco CP; Magolda RL
    Bioorg Med Chem Lett; 1998 Apr; 8(7):837-42. PubMed ID: 9871551
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Matrix metalloproteinase inhibitors: a review on pharmacophore mapping and (Q)SARs results.
    Kontogiorgis CA; Papaioannou P; Hadjipavlou-Litina DJ
    Curr Med Chem; 2005; 12(3):339-55. PubMed ID: 15723623
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and evaluation of matrix metalloprotease inhibitors bearing cyclopropane-derived peptidomimetics as P1' and P2' replacements.
    Reichelt A; Gaul C; Frey RR; Kennedy A; Martin SF
    J Org Chem; 2002 Jun; 67(12):4062-75. PubMed ID: 12054939
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.
    Tochowicz A; Maskos K; Huber R; Oltenfreiter R; Dive V; Yiotakis A; Zanda M; Pourmotabbed T; Bode W; Goettig P
    J Mol Biol; 2007 Aug; 371(4):989-1006. PubMed ID: 17599356
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chemically modified tetracyclines as inhibitors of MMP-2 matrix metalloproteinase: a molecular and structural study.
    Marcial BL; Sousa SF; Barbosa IL; Dos Santos HF; Ramos MJ
    J Phys Chem B; 2012 Nov; 116(46):13644-54. PubMed ID: 23121406
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An integrated computational and experimental approach to gaining selectivity for MMP-2 within the gelatinase subfamily.
    Fabre B; Filipiak K; Díaz N; Zapico JM; Suárez D; Ramos A; de Pascual-Teresa B
    Chembiochem; 2014 Feb; 15(3):399-412. PubMed ID: 24449516
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Binding preferences of hydroxamate inhibitors of the matrix metalloproteinase human fibroblast collagenase.
    Toba S; Damodaran KV; Merz KM
    J Med Chem; 1999 Apr; 42(7):1225-34. PubMed ID: 10197966
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling.
    Park HI; Jin Y; Hurst DR; Monroe CA; Lee S; Schwartz MA; Sang QX
    J Biol Chem; 2003 Dec; 278(51):51646-53. PubMed ID: 14532275
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Three-dimensional quantitative structure-activity relationship (CoMFA and CoMSIA) studies on galardin derivatives as gelatinase A (matrix metalloproteinase 2) inhibitors.
    Zheng J; Wen R; Guillaume D
    J Enzyme Inhib Med Chem; 2008 Aug; 23(4):445-53. PubMed ID: 18665992
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Binding affinity of hydroxamate inhibitors of matrix metalloproteinase-2.
    Zhang W; Hou TJ; Qiao XB; Huai S; Xu XJ
    J Mol Model; 2004 Apr; 10(2):112-20. PubMed ID: 14986176
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds.
    Lenci E; Innocenti R; Di Francescantonio T; Menchi G; Bianchini F; Contini A; Trabocchi A
    Bioorg Med Chem; 2019 May; 27(9):1891-1902. PubMed ID: 30926311
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular dynamics simulations of metalloproteinases types 2 and 3 reveal differences in the dynamic behavior of the S1' binding pocket.
    de Oliveira CA; Zissen M; Mongon J; McCammon JA
    Curr Pharm Des; 2007; 13(34):3471-5. PubMed ID: 18220784
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors.
    Hurst DR; Schwartz MA; Jin Y; Ghaffari MA; Kozarekar P; Cao J; Sang QX
    Biochem J; 2005 Dec; 392(Pt 3):527-36. PubMed ID: 16026329
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality.
    Fray MJ; Burslem MF; Dickinson RP
    Bioorg Med Chem Lett; 2001 Feb; 11(4):567-70. PubMed ID: 11229773
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.
    Tsunemi M; Matsuura Y; Sakakibara S; Katsube Y
    Biochemistry; 1996 Sep; 35(36):11570-6. PubMed ID: 8794736
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
    Brandstetter H; Grams F; Glitz D; Lang A; Huber R; Bode W; Krell HW; Engh RA
    J Biol Chem; 2001 May; 276(20):17405-12. PubMed ID: 11278347
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.