902 related articles for article (PubMed ID: 12202038)
1. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Yang T; Espenshade PJ; Wright ME; Yabe D; Gong Y; Aebersold R; Goldstein JL; Brown MS
Cell; 2002 Aug; 110(4):489-500. PubMed ID: 12202038
[TBL] [Abstract][Full Text] [Related]
2. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.
Yang T; Goldstein JL; Brown MS
J Biol Chem; 2000 Sep; 275(38):29881-6. PubMed ID: 10896675
[TBL] [Abstract][Full Text] [Related]
3. Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
Lee PC; Sever N; Debose-Boyd RA
J Biol Chem; 2005 Jul; 280(26):25242-9. PubMed ID: 15866869
[TBL] [Abstract][Full Text] [Related]
4. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Yabe D; Brown MS; Goldstein JL
Proc Natl Acad Sci U S A; 2002 Oct; 99(20):12753-8. PubMed ID: 12242332
[TBL] [Abstract][Full Text] [Related]
5. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
Sun LP; Li L; Goldstein JL; Brown MS
J Biol Chem; 2005 Jul; 280(28):26483-90. PubMed ID: 15899885
[TBL] [Abstract][Full Text] [Related]
6. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.
Nohturfft A; DeBose-Boyd RA; Scheek S; Goldstein JL; Brown MS
Proc Natl Acad Sci U S A; 1999 Sep; 96(20):11235-40. PubMed ID: 10500160
[TBL] [Abstract][Full Text] [Related]
7. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
Yabe D; Xia ZP; Adams CM; Rawson RB
Proc Natl Acad Sci U S A; 2002 Dec; 99(26):16672-7. PubMed ID: 12482938
[TBL] [Abstract][Full Text] [Related]
8. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.
Dobrosotskaya IY; Goldstein JL; Brown MS; Rawson RB
J Biol Chem; 2003 Sep; 278(37):35837-43. PubMed ID: 12842885
[TBL] [Abstract][Full Text] [Related]
9. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.
Sever N; Yang T; Brown MS; Goldstein JL; DeBose-Boyd RA
Mol Cell; 2003 Jan; 11(1):25-33. PubMed ID: 12535518
[TBL] [Abstract][Full Text] [Related]
10. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
Gong Y; Lee JN; Lee PC; Goldstein JL; Brown MS; Ye J
Cell Metab; 2006 Jan; 3(1):15-24. PubMed ID: 16399501
[TBL] [Abstract][Full Text] [Related]
11. Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.
Nohturfft A; Brown MS; Goldstein JL
Proc Natl Acad Sci U S A; 1998 Oct; 95(22):12848-53. PubMed ID: 9789003
[TBL] [Abstract][Full Text] [Related]
12. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.
DeBose-Boyd RA; Brown MS; Li WP; Nohturfft A; Goldstein JL; Espenshade PJ
Cell; 1999 Dec; 99(7):703-12. PubMed ID: 10619424
[TBL] [Abstract][Full Text] [Related]
13. Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor.
Heemers H; Verrijdt G; Organe S; Claessens F; Heyns W; Verhoeven G; Swinnen JV
J Biol Chem; 2004 Jul; 279(29):30880-7. PubMed ID: 15133039
[TBL] [Abstract][Full Text] [Related]
14. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
Korn BS; Shimomura I; Bashmakov Y; Hammer RE; Horton JD; Goldstein JL; Brown MS
J Clin Invest; 1998 Dec; 102(12):2050-60. PubMed ID: 9854040
[TBL] [Abstract][Full Text] [Related]
15. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes.
Nohturfft A; Yabe D; Goldstein JL; Brown MS; Espenshade PJ
Cell; 2000 Aug; 102(3):315-23. PubMed ID: 10975522
[TBL] [Abstract][Full Text] [Related]
16. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites.
Su L; Zhou L; Chen FJ; Wang H; Qian H; Sheng Y; Zhu Y; Yu H; Gong X; Cai L; Yang X; Xu L; Zhao TJ; Li JZ; Chen XW; Li P
EMBO J; 2019 Apr; 38(8):. PubMed ID: 30858281
[TBL] [Abstract][Full Text] [Related]
17. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.
Sakai J; Nohturfft A; Goldstein JL; Brown MS
J Biol Chem; 1998 Mar; 273(10):5785-93. PubMed ID: 9488713
[TBL] [Abstract][Full Text] [Related]
18. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.
Sakai J; Nohturfft A; Cheng D; Ho YK; Brown MS; Goldstein JL
J Biol Chem; 1997 Aug; 272(32):20213-21. PubMed ID: 9242699
[TBL] [Abstract][Full Text] [Related]
19. Assaying Sterol-Regulated ER-to-Golgi Transport of SREBP Cleavage-Activating Protein Using Immunofluorescence Microscopy.
Ishida CT; Shao W; Espenshade PJ
Methods Mol Biol; 2023; 2557():755-764. PubMed ID: 36512249
[TBL] [Abstract][Full Text] [Related]
20. COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions.
Takashima K; Saitoh A; Funabashi T; Hirose S; Yagi C; Nozaki S; Sato R; Shin HW; Nakayama K
J Cell Sci; 2015 Aug; 128(15):2805-15. PubMed ID: 26092941
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]