These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 12221087)

  • 1. Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication.
    Angus SP; Wheeler LJ; Ranmal SA; Zhang X; Markey MP; Mathews CK; Knudsen ES
    J Biol Chem; 2002 Nov; 277(46):44376-84. PubMed ID: 12221087
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.
    Yin MB; Guo B; Panadero A; Frank C; Wrzosek C; Slocum HK; Rustum YM
    Exp Cell Res; 1999 Feb; 247(1):189-99. PubMed ID: 10047461
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.
    Sever-Chroneos Z; Angus SP; Fribourg AF; Wan H; Todorov I; Knudsen KE; Knudsen ES
    Mol Cell Biol; 2001 Jun; 21(12):4032-45. PubMed ID: 11359910
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2.
    Lan Z; Sever-Chroneos Z; Strobeck MW; Park CH; Baskaran R; Edelmann W; Leone G; Knudsen ES
    J Biol Chem; 2002 Mar; 277(10):8372-81. PubMed ID: 11726663
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest.
    Strobeck MW; Fribourg AF; Puga A; Knudsen ES
    Oncogene; 2000 Apr; 19(15):1857-67. PubMed ID: 10773875
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differential requirements for ras and the retinoblastoma tumor suppressor protein in the androgen dependence of prostatic adenocarcinoma cells.
    Fribourg AF; Knudsen KE; Strobeck MW; Lindhorst CM; Knudsen ES
    Cell Growth Differ; 2000 Jul; 11(7):361-72. PubMed ID: 10939590
    [TBL] [Abstract][Full Text] [Related]  

  • 7. S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation.
    Leng X; Connell-Crowley L; Goodrich D; Harper JW
    Curr Biol; 1997 Sep; 7(9):709-12. PubMed ID: 9285720
    [TBL] [Abstract][Full Text] [Related]  

  • 8. TGF-beta-mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21(WAF-1) expression.
    Rorke EA; Zhang D; Choo CK; Eckert RL; Jacobberger JW
    Exp Cell Res; 2000 Aug; 259(1):149-57. PubMed ID: 10942587
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein.
    Ryhänen S; Jääskeläinen T; Mahonen A; Mäenpää PH
    Biochem Pharmacol; 2003 Aug; 66(3):495-504. PubMed ID: 12907249
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.
    Zhang HS; Gavin M; Dahiya A; Postigo AA; Ma D; Luo RX; Harbour JW; Dean DC
    Cell; 2000 Mar; 101(1):79-89. PubMed ID: 10778858
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Helicobacter pylori releases a factor(s) inhibiting cell cycle progression of human gastric cell lines by affecting cyclin E/cdk2 kinase activity and Rb protein phosphorylation through enhanced p27(KIP1) protein expression.
    Sommi P; Savio M; Stivala LA; Scotti C; Mignosi P; Prosperi E; Vannini V; Solcia E
    Exp Cell Res; 2002 Nov; 281(1):128-39. PubMed ID: 12441136
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.
    Lents NH; Keenan SM; Bellone C; Baldassare JJ
    J Biol Chem; 2002 Dec; 277(49):47469-75. PubMed ID: 12359725
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein.
    Reshetnikova G; Barkan R; Popov B; Nikolsky N; Chang LS
    Exp Cell Res; 2000 Aug; 259(1):35-53. PubMed ID: 10942577
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest.
    Knudsen KE; Fribourg AF; Strobeck MW; Blanchard JM; Knudsen ES
    J Biol Chem; 1999 Sep; 274(39):27632-41. PubMed ID: 10488103
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip).
    Chen WJ; Chang CY; Lin JK
    Biochem Pharmacol; 2003 Jun; 65(11):1777-85. PubMed ID: 12781329
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thyroid hormone-induced cell proliferation in GC cells is mediated by changes in G1 cyclin/cyclin-dependent kinase levels and activity.
    Barrera-Hernandez G; Park KS; Dace A; Zhan Q; Cheng SY
    Endocrinology; 1999 Nov; 140(11):5267-74. PubMed ID: 10537157
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Androgen stimulated cellular proliferation in the human prostate cancer cell line LNCaP is associated with reduced retinoblastoma protein expression.
    Taneja SS; Ha S; Garabedian MJ
    J Cell Biochem; 2001; 84(1):188-99. PubMed ID: 11746527
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
    Srethapakdi M; Liu F; Tavorath R; Rosen N
    Cancer Res; 2000 Jul; 60(14):3940-6. PubMed ID: 10919672
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.
    Leone G; DeGregori J; Sears R; Jakoi L; Nevins JR
    Nature; 1997 May; 387(6631):422-6. PubMed ID: 9163430
    [TBL] [Abstract][Full Text] [Related]  

  • 20. p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells.
    Brugarolas J; Bronson RT; Jacks T
    J Cell Biol; 1998 Apr; 141(2):503-14. PubMed ID: 9548727
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.