461 related articles for article (PubMed ID: 12223485)
1. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
Lammich S; Okochi M; Takeda M; Kaether C; Capell A; Zimmer AK; Edbauer D; Walter J; Steiner H; Haass C
J Biol Chem; 2002 Nov; 277(47):44754-9. PubMed ID: 12223485
[TBL] [Abstract][Full Text] [Related]
2. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
3. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
[TBL] [Abstract][Full Text] [Related]
4. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
Xia W
Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
[TBL] [Abstract][Full Text] [Related]
5. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
6. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.
Sastre M; Steiner H; Fuchs K; Capell A; Multhaup G; Condron MM; Teplow DB; Haass C
EMBO Rep; 2001 Sep; 2(9):835-41. PubMed ID: 11520861
[TBL] [Abstract][Full Text] [Related]
7. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
Okochi M; Steiner H; Fukumori A; Tanii H; Tomita T; Tanaka T; Iwatsubo T; Kudo T; Takeda M; Haass C
EMBO J; 2002 Oct; 21(20):5408-16. PubMed ID: 12374741
[TBL] [Abstract][Full Text] [Related]
8. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Martys-Zage JL; Kim SH; Berechid B; Bingham SJ; Chu S; Sklar J; Nye J; Sisodia SS
J Mol Neurosci; 2000 Dec; 15(3):189-204. PubMed ID: 11303783
[TBL] [Abstract][Full Text] [Related]
9. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
[TBL] [Abstract][Full Text] [Related]
10. Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
Pitsi D; Octave JN
J Biol Chem; 2004 Jun; 279(24):25333-8. PubMed ID: 15087467
[TBL] [Abstract][Full Text] [Related]
11. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.
Murakami D; Okamoto I; Nagano O; Kawano Y; Tomita T; Iwatsubo T; De Strooper B; Yumoto E; Saya H
Oncogene; 2003 Mar; 22(10):1511-6. PubMed ID: 12629514
[TBL] [Abstract][Full Text] [Related]
12. Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.
Kim DY; Ingano LA; Carey BW; Pettingell WH; Kovacs DM
J Biol Chem; 2005 Jun; 280(24):23251-61. PubMed ID: 15833746
[TBL] [Abstract][Full Text] [Related]
13. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
[TBL] [Abstract][Full Text] [Related]
14. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Li T; Ma G; Cai H; Price DL; Wong PC
J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
[TBL] [Abstract][Full Text] [Related]
15. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
Chen F; Gu Y; Hasegawa H; Ruan X; Arawaka S; Fraser P; Westaway D; Mount H; St George-Hyslop P
J Biol Chem; 2002 Sep; 277(39):36521-6. PubMed ID: 12119298
[TBL] [Abstract][Full Text] [Related]
16. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
Fluhrer R; Multhaup G; Schlicksupp A; Okochi M; Takeda M; Lammich S; Willem M; Westmeyer G; Bode W; Walter J; Haass C
J Biol Chem; 2003 Feb; 278(8):5531-8. PubMed ID: 12471021
[TBL] [Abstract][Full Text] [Related]
17. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
18. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.
Geling A; Steiner H; Willem M; Bally-Cuif L; Haass C
EMBO Rep; 2002 Jul; 3(7):688-94. PubMed ID: 12101103
[TBL] [Abstract][Full Text] [Related]
19. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
Qi-Takahara Y; Morishima-Kawashima M; Tanimura Y; Dolios G; Hirotani N; Horikoshi Y; Kametani F; Maeda M; Saido TC; Wang R; Ihara Y
J Neurosci; 2005 Jan; 25(2):436-45. PubMed ID: 15647487
[TBL] [Abstract][Full Text] [Related]
20. Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Ikeuchi T; Dolios G; Kim SH; Wang R; Sisodia SS
J Biol Chem; 2003 Feb; 278(9):7010-8. PubMed ID: 12493731
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
