110 related articles for article (PubMed ID: 12224634)
1. Recognition of a cysteine substrate by E. coli gamma-glutamylcysteine synthetase probed by sulfoximine-based transition-state analogue inhibitors.
Hiratake J; Irie T; Tokutake N; Oda J
Biosci Biotechnol Biochem; 2002 Jul; 66(7):1500-14. PubMed ID: 12224634
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis and evaluation of transition-state analogue inhibitors of Escherichia coli gamma-glutamylcysteine synthetase.
Tokutake N; Hiratake J; Katoh M; Irie T; Kato H; Oda J
Bioorg Med Chem; 1998 Oct; 6(10):1935-53. PubMed ID: 9839023
[TBL] [Abstract][Full Text] [Related]
3. Escherichia coli gamma-glutamylcysteine synthetase. Two active site metal ions affect substrate and inhibitor binding.
Kelly BS; Antholine WE; Griffith OW
J Biol Chem; 2002 Jan; 277(1):50-8. PubMed ID: 11675389
[TBL] [Abstract][Full Text] [Related]
4. Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.
Vázquez C; Mejia-Tlachi M; González-Chávez Z; Silva A; Rodríguez-Zavala JS; Moreno-Sánchez R; Saavedra E
FEBS Lett; 2017 Dec; 591(23):3881-3894. PubMed ID: 29127710
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and characterization of intermediate and transition-state analogue inhibitors of gamma-glutamyl peptide ligases.
Inoue M; Hiratake J; Sakata K
Biosci Biotechnol Biochem; 1999 Dec; 63(12):2248-51. PubMed ID: 10664863
[TBL] [Abstract][Full Text] [Related]
6. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
Griffith OW; Meister A
J Biol Chem; 1979 Aug; 254(16):7558-60. PubMed ID: 38242
[TBL] [Abstract][Full Text] [Related]
7. L-Buthionine-(S,R)-sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, augments LPS-mediated pro-inflammatory cytokine biosynthesis: evidence for the implication of an IkappaB-alpha/NF-kappaB insensitive pathway.
Haddad JJ
Eur Cytokine Netw; 2001; 12(4):614-24. PubMed ID: 11781188
[TBL] [Abstract][Full Text] [Related]
8. Purification and characterization of gamma-glutamylcysteine synthetase from Ascaris suum.
Hussein AS; Walter RD
Mol Biochem Parasitol; 1995 Jun; 72(1-2):57-64. PubMed ID: 8538700
[TBL] [Abstract][Full Text] [Related]
9. Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure.
Cuzzocrea S; Zingarelli B; O'Connor M; Salzman AL; Szabó C
Br J Pharmacol; 1998 Feb; 123(3):525-37. PubMed ID: 9504394
[TBL] [Abstract][Full Text] [Related]
10. gamma-Glutamylcysteine synthetase in lung cancer. Effect on cell viability.
Järvinen K; Soini Y; Kinnula VL
Methods Mol Med; 2003; 74():211-22. PubMed ID: 12415696
[No Abstract] [Full Text] [Related]
11. Glutathione: an overview of biosynthesis and modulation.
Anderson ME
Chem Biol Interact; 1998 Apr; 111-112():1-14. PubMed ID: 9679538
[TBL] [Abstract][Full Text] [Related]
12. On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.
Huang CS; Moore WR; Meister A
Proc Natl Acad Sci U S A; 1988 Apr; 85(8):2464-8. PubMed ID: 2895925
[TBL] [Abstract][Full Text] [Related]
13. Glutathione homeostasis in human hepatic cells: overexpression of gamma-glutamylcysteine synthetase gene in cell lines resistant to buthionine sulfoximine, an inhibitor of glutathione synthesis.
Tanaka T; Uchiumi T; Kohno K; Tomonari A; Nishio K; Saijo N; Kondo T; Kuwano M
Biochem Biophys Res Commun; 1998 May; 246(2):398-403. PubMed ID: 9610371
[TBL] [Abstract][Full Text] [Related]
14. Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes.
Kwon YH; Stipanuk MH
Am J Physiol Endocrinol Metab; 2001 May; 280(5):E804-15. PubMed ID: 11287364
[TBL] [Abstract][Full Text] [Related]
15. Molecular modulated cysteine-selective fluorescent probe.
Jung HS; Pradhan T; Han JH; Heo KJ; Lee JH; Kang C; Kim JS
Biomaterials; 2012 Nov; 33(33):8495-502. PubMed ID: 22906610
[TBL] [Abstract][Full Text] [Related]
16. Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation.
Brekken DL; Phillips MA
J Biol Chem; 1998 Oct; 273(41):26317-22. PubMed ID: 9756861
[TBL] [Abstract][Full Text] [Related]
17. Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis.
Hibi T; Nii H; Nakatsu T; Kimura A; Kato H; Hiratake J; Oda J
Proc Natl Acad Sci U S A; 2004 Oct; 101(42):15052-7. PubMed ID: 15477603
[TBL] [Abstract][Full Text] [Related]
18. Determination of glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) activity by high-performance liquid chromatography and electrochemical detection.
Gegg ME; Clark JB; Heales SJ
Anal Biochem; 2002 May; 304(1):26-32. PubMed ID: 11969185
[TBL] [Abstract][Full Text] [Related]
19. Glutathione synthesis in Streptococcus agalactiae. One protein accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities.
Janowiak BE; Griffith OW
J Biol Chem; 2005 Mar; 280(12):11829-39. PubMed ID: 15642737
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of glutathione synthesis as a chemotherapeutic strategy for leishmaniasis.
Kapoor P; Sachdev M; Madhubala R
Trop Med Int Health; 2000 Jun; 5(6):438-42. PubMed ID: 10929144
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]