150 related articles for article (PubMed ID: 12234866)
1. Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid.
Reinke R; Lee DJ; Robinson WE
Antimicrob Agents Chemother; 2002 Oct; 46(10):3301-3. PubMed ID: 12234866
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Pluymers W; Pais G; Van Maele B; Pannecouque C; Fikkert V; Burke TR; De Clercq E; Witvrouw M; Neamati N; Debyser Z
Antimicrob Agents Chemother; 2002 Oct; 46(10):3292-7. PubMed ID: 12234864
[TBL] [Abstract][Full Text] [Related]
3. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.
Hazuda DJ; Felock P; Witmer M; Wolfe A; Stillmock K; Grobler JA; Espeseth A; Gabryelski L; Schleif W; Blau C; Miller MD
Science; 2000 Jan; 287(5453):646-50. PubMed ID: 10649997
[TBL] [Abstract][Full Text] [Related]
4. Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Fikkert V; Van Maele B; Vercammen J; Hantson A; Van Remoortel B; Michiels M; Gurnari C; Pannecouque C; De Maeyer M; Engelborghs Y; De Clercq E; Debyser Z; Witvrouw M
J Virol; 2003 Nov; 77(21):11459-70. PubMed ID: 14557631
[TBL] [Abstract][Full Text] [Related]
5. Human immunodeficiency virus type-1 integrase containing a glycine to serine mutation at position 140 is attenuated for catalysis and resistant to integrase inhibitors.
King PJ; Lee DJ; Reinke RA; Victoria JG; Beale K; Robinson WE
Virology; 2003 Feb; 306(1):147-61. PubMed ID: 12620807
[TBL] [Abstract][Full Text] [Related]
6. Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase.
Vandegraaff N; Kumar R; Hocking H; Burke TR; Mills J; Rhodes D; Burrell CJ; Li P
Antimicrob Agents Chemother; 2001 Sep; 45(9):2510-6. PubMed ID: 11502522
[TBL] [Abstract][Full Text] [Related]
7. HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial.
Johnson AA; Marchand C; Pommier Y
Curr Top Med Chem; 2004; 4(10):1059-77. PubMed ID: 15193139
[TBL] [Abstract][Full Text] [Related]
8. Fully flexible low-mode docking: application to induced fit in HIV integrase.
Keserû GM; Kolossváry I
J Am Chem Soc; 2001 Dec; 123(50):12708-9. PubMed ID: 11741448
[No Abstract] [Full Text] [Related]
9. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.
Espeseth AS; Felock P; Wolfe A; Witmer M; Grobler J; Anthony N; Egbertson M; Melamed JY; Young S; Hamill T; Cole JL; Hazuda DJ
Proc Natl Acad Sci U S A; 2000 Oct; 97(21):11244-9. PubMed ID: 11016953
[TBL] [Abstract][Full Text] [Related]
10. Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.
Svarovskaia ES; Barr R; Zhang X; Pais GC; Marchand C; Pommier Y; Burke TR; Pathak VK
J Virol; 2004 Apr; 78(7):3210-22. PubMed ID: 15016842
[TBL] [Abstract][Full Text] [Related]
11. Human immunodeficiency virus type 1 (HIV-1) integrase: resistance to diketo acid integrase inhibitors impairs HIV-1 replication and integration and confers cross-resistance to L-chicoric acid.
Lee DJ; Robinson WE
J Virol; 2004 Jun; 78(11):5835-47. PubMed ID: 15140981
[TBL] [Abstract][Full Text] [Related]
12. L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro.
Reinke RA; Lee DJ; McDougall BR; King PJ; Victoria J; Mao Y; Lei X; Reinecke MG; Robinson WE
Virology; 2004 Sep; 326(2):203-19. PubMed ID: 15302207
[TBL] [Abstract][Full Text] [Related]
13. Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
Pais GC; Zhang X; Marchand C; Neamati N; Cowansage K; Svarovskaia ES; Pathak VK; Tang Y; Nicklaus M; Pommier Y; Burke TR
J Med Chem; 2002 Jul; 45(15):3184-94. PubMed ID: 12109903
[TBL] [Abstract][Full Text] [Related]
14. The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Garvey EP; Johns BA; Gartland MJ; Foster SA; Miller WH; Ferris RG; Hazen RJ; Underwood MR; Boros EE; Thompson JB; Weatherhead JG; Koble CS; Allen SH; Schaller LT; Sherrill RG; Yoshinaga T; Kobayashi M; Wakasa-Morimoto C; Miki S; Nakahara K; Noshi T; Sato A; Fujiwara T
Antimicrob Agents Chemother; 2008 Mar; 52(3):901-8. PubMed ID: 18160521
[TBL] [Abstract][Full Text] [Related]
15. Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.
Hombrouck A; Voet A; Van Remoortel B; Desadeleer C; De Maeyer M; Debyser Z; Witvrouw M
Antimicrob Agents Chemother; 2008 Jun; 52(6):2069-78. PubMed ID: 18378713
[TBL] [Abstract][Full Text] [Related]
16. New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H.
Corona A; di Leva FS; Rigogliuso G; Pescatori L; Madia VN; Subra F; Delelis O; Esposito F; Cadeddu M; Costi R; Cosconati S; Novellino E; di Santo R; Tramontano E
Antiviral Res; 2016 Oct; 134():236-243. PubMed ID: 27659398
[TBL] [Abstract][Full Text] [Related]
17. Diketoacid inhibitors of HIV-1 integrase: from L-708,906 to raltegravir and beyond.
Beare KD; Coster MJ; Rutledge PJ
Curr Med Chem; 2012; 19(8):1177-92. PubMed ID: 22214459
[TBL] [Abstract][Full Text] [Related]
18. Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture.
Reddy MV; Rao MR; Rhodes D; Hansen MS; Rubins K; Bushman FD; Venkateswarlu Y; Faulkner DJ
J Med Chem; 1999 Jun; 42(11):1901-7. PubMed ID: 10354398
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
Patil S; Kamath S; Sanchez T; Neamati N; Schinazi RF; Buolamwini JK
Bioorg Med Chem; 2007 Feb; 15(3):1212-28. PubMed ID: 17158051
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Langford HM; Williams PD; Homnick CF; Vacca JP; Felock PJ; Stillmock KA; Witmer MV; Hazuda DJ; Gabryelski LJ; Schleif WA
Bioorg Med Chem Lett; 2008 Jan; 18(2):721-5. PubMed ID: 18078751
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]