BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 12235158)

  • 1. Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site.
    Prosise GL; Wu JZ; Luecke H
    J Biol Chem; 2002 Dec; 277(52):50654-9. PubMed ID: 12235158
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
    Prosise GL; Luecke H
    J Mol Biol; 2003 Feb; 326(2):517-27. PubMed ID: 12559919
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis.
    Gan L; Petsko GA; Hedstrom L
    Biochemistry; 2002 Nov; 41(44):13309-17. PubMed ID: 12403633
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tritrichomonas foetus: a strategy for structure-based inhibitor design of a protozoan inosine-5'-monophosphate dehydrogenase.
    Luecke H; Prosise GL; Whitby FG
    Exp Parasitol; 1997 Nov; 87(3):203-11. PubMed ID: 9371085
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.
    Whitby FG; Luecke H; Kuhn P; Somoza JR; Huete-Perez JA; Phillips JD; Hill CP; Fletterick RJ; Wang CC
    Biochemistry; 1997 Sep; 36(35):10666-74. PubMed ID: 9271497
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase.
    Digits JA; Hedstrom L
    Biochemistry; 1999 Feb; 38(8):2295-306. PubMed ID: 10029522
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Acid-base catalysis in the chemical mechanism of inosine monophosphate dehydrogenase.
    Markham GD; Bock CL; Schalk-Hihi C
    Biochemistry; 1999 Apr; 38(14):4433-40. PubMed ID: 10194364
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mycophenolic acid and thiazole adenine dinucleotide inhibition of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: implications on enzyme mechanism.
    Hedstrom L; Wang CC
    Biochemistry; 1990 Jan; 29(4):849-54. PubMed ID: 1971185
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid.
    Digits JA; Hedstrom L
    Biochemistry; 1999 Nov; 38(46):15388-97. PubMed ID: 10563825
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.
    McMillan FM; Cahoon M; White A; Hedstrom L; Petsko GA; Ringe D
    Biochemistry; 2000 Apr; 39(15):4533-42. PubMed ID: 10758003
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction.
    Guillén Schlippe YV; Riera TV; Seyedsayamdost MR; Hedstrom L
    Biochemistry; 2004 Apr; 43(15):4511-21. PubMed ID: 15078097
    [TBL] [Abstract][Full Text] [Related]  

  • 12. IMP dehydrogenase : structural aspects of inhibitor binding.
    Goldstein BM; Colby TD
    Curr Med Chem; 1999 Jul; 6(7):519-36. PubMed ID: 10390598
    [TBL] [Abstract][Full Text] [Related]  

  • 13. IMP dehydrogenase: mechanism of action and inhibition.
    Hedstrom L
    Curr Med Chem; 1999 Jul; 6(7):545-60. PubMed ID: 10390600
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
    Sintchak MD; Nimmesgern E
    Immunopharmacology; 2000 May; 47(2-3):163-84. PubMed ID: 10878288
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.
    Makowska-Grzyska M; Kim Y; Wu R; Wilton R; Gollapalli DR; Wang XK; Zhang R; Jedrzejczak R; Mack JC; Maltseva N; Mulligan R; Binkowski TA; Gornicki P; Kuhn ML; Anderson WF; Hedstrom L; Joachimiak A
    Biochemistry; 2012 Aug; 51(31):6148-63. PubMed ID: 22788966
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase.
    Gan L; Seyedsayamdost MR; Shuto S; Matsuda A; Petsko GA; Hedstrom L
    Biochemistry; 2003 Feb; 42(4):857-63. PubMed ID: 12549902
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Differential signatures of bacterial and mammalian IMP dehydrogenase enzymes.
    Zhang R; Evans G; Rotella F; Westbrook E; Huberman E; Joachimiak A; Collart FR
    Curr Med Chem; 1999 Jul; 6(7):537-43. PubMed ID: 10390599
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cloning, sequencing, and structural analysis of the DNA encoding inosine monophosphate dehydrogenase (EC 1.1.1.205) from Tritrichomonas foetus.
    Beck JT; Zhao S; Wang CC
    Exp Parasitol; 1994 Feb; 78(1):101-12. PubMed ID: 7905423
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
    Makowska-Grzyska M; Kim Y; Maltseva N; Osipiuk J; Gu M; Zhang M; Mandapati K; Gollapalli DR; Gorla SK; Hedstrom L; Joachimiak A
    J Biol Chem; 2015 Feb; 290(9):5893-911. PubMed ID: 25572472
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of the IMP binding site in the IMP dehydrogenase from Tritrichomonas foetus.
    Huete-Pérez JA; Wu JC; Whitby FG; Wang CC
    Biochemistry; 1995 Oct; 34(42):13889-94. PubMed ID: 7577983
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.