148 related articles for article (PubMed ID: 12238931)
1. Coupling of a competitive and an irreversible ligand generates mixed type inhibitors of Trypanosoma cruzi trypanothione reductase.
Inhoff O; Richards JM; Brîet JW; Lowe G; Krauth-Siegel RL
J Med Chem; 2002 Sep; 45(20):4524-30. PubMed ID: 12238931
[TBL] [Abstract][Full Text] [Related]
2. (2,2':6',2"-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase.
Bonse S; Richards JM; Ross SA; Lowe G; Krauth-Siegel RL
J Med Chem; 2000 Dec; 43(25):4812-21. PubMed ID: 11123991
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships.
Bonse S; Santelli-Rouvier C; Barbe J; Krauth-Siegel RL
J Med Chem; 1999 Dec; 42(26):5448-54. PubMed ID: 10639286
[TBL] [Abstract][Full Text] [Related]
4. Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
Li Z; Fennie MW; Ganem B; Hancock MT; Kobaslija M; Rattendi D; Bacchi CJ; O'Sullivan MC
Bioorg Med Chem Lett; 2001 Jan; 11(2):251-4. PubMed ID: 11206471
[TBL] [Abstract][Full Text] [Related]
5. Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds.
Jockers-Scherübl MC; Schirmer RH; Krauth-Siegel RL
Eur J Biochem; 1989 Mar; 180(2):267-72. PubMed ID: 2647489
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase.
Duyzend MH; Clark CT; Simmons SL; Johnson WB; Larson AM; Leconte AM; Wills AW; Ginder-Vogel M; Wilhelm AK; Czechowicz JA; Alberg DG
J Enzyme Inhib Med Chem; 2012 Dec; 27(6):784-94. PubMed ID: 22085139
[TBL] [Abstract][Full Text] [Related]
7. Inhibiting effects of spermidine derivatives on Trypanosoma cruzi trypanothione reductase.
O'Sullivan MC; Dalrymple DM; Zhou Q
J Enzyme Inhib; 1996 Oct; 11(2):97-114. PubMed ID: 9204399
[TBL] [Abstract][Full Text] [Related]
8. Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.
Girault S; Davioud-Charvet E; Salmon L; Berecibar A; Debreu MA; Sergheraert C
Bioorg Med Chem Lett; 1998 May; 8(10):1175-80. PubMed ID: 9871730
[TBL] [Abstract][Full Text] [Related]
9. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
Chan C; Yin H; Garforth J; McKie JH; Jaouhari R; Speers P; Douglas KT; Rock PJ; Yardley V; Croft SL; Fairlamb AH
J Med Chem; 1998 Jan; 41(2):148-56. PubMed ID: 9457238
[TBL] [Abstract][Full Text] [Related]
10. Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead.
Chan C; Yin H; McKie JH; Fairlamb AH; Douglas KT
Amino Acids; 2002 Jun; 22(4):297-308. PubMed ID: 12107758
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
Hartmann AP; de Carvalho MR; Bernardes LSC; Moraes MH; de Melo EB; Lopes CD; Steindel M; da Silva JS; Carvalho I
Eur J Med Chem; 2017 Nov; 140():187-199. PubMed ID: 28926763
[TBL] [Abstract][Full Text] [Related]
12. Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.
Khan MO; Austin SE; Chan C; Yin H; Marks D; Vaghjiani SN; Kendrick H; Yardley V; Croft SL; Douglas KT
J Med Chem; 2000 Aug; 43(16):3148-56. PubMed ID: 10956223
[TBL] [Abstract][Full Text] [Related]
13. Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease.
Beltran-Hortelano I; Perez-Silanes S; Galiano S
Curr Med Chem; 2017 May; 24(11):1066-1138. PubMed ID: 28025938
[TBL] [Abstract][Full Text] [Related]
14. The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.
Galarreta BC; Sifuentes R; Carrillo AK; Sanchez L; Amado Mdel R; Maruenda H
Bioorg Med Chem; 2008 Jul; 16(14):6689-95. PubMed ID: 18558492
[TBL] [Abstract][Full Text] [Related]
15. Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis.
Meiering S; Inhoff O; Mies J; Vincek A; Garcia G; Kramer B; Dormeyer M; Krauth-Siegel RL
J Med Chem; 2005 Jul; 48(15):4793-802. PubMed ID: 16033259
[TBL] [Abstract][Full Text] [Related]
16. 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
Salmon-Chemin L; Buisine E; Yardley V; Kohler S; Debreu MA; Landry V; Sergheraert C; Croft SL; Krauth-Siegel RL; Davioud-Charvet E
J Med Chem; 2001 Feb; 44(4):548-65. PubMed ID: 11170645
[TBL] [Abstract][Full Text] [Related]
17. Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.
Lee B; Bauer H; Melchers J; Ruppert T; Rattray L; Yardley V; Davioud-Charvet E; Krauth-Siegel RL
J Med Chem; 2005 Nov; 48(23):7400-10. PubMed ID: 16279799
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of trypanothione reductase by substrate analogues.
Garrard EA; Borman EC; Cook BN; Pike EJ; Alberg DG
Org Lett; 2000 Nov; 2(23):3639-42. PubMed ID: 11073664
[TBL] [Abstract][Full Text] [Related]
19. Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors.
Faerman CH; Savvides SN; Strickland C; Breidenbach MA; Ponasik JA; Ganem B; Ripoll D; Krauth-Siegel RL; Karplus PA
Bioorg Med Chem; 1996 Aug; 4(8):1247-53. PubMed ID: 8879546
[TBL] [Abstract][Full Text] [Related]
20. Identification of potential trypanothione reductase inhibitors among commercially available β-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.
Rodríguez-Becerra J; Cáceres-Jensen L; Hernández-Ramos J; Barrientos L
Mol Divers; 2017 Aug; 21(3):697-711. PubMed ID: 28656524
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]