BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

255 related articles for article (PubMed ID: 12241545)

  • 1. Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.
    Laursen LS; Overgaard MT; Nielsen CG; Boldt HB; Hopmann KH; Conover CA; Sottrup-Jensen L; Giudice LC; Oxvig C
    Biochem J; 2002 Oct; 367(Pt 1):31-40. PubMed ID: 12241545
    [TBL] [Abstract][Full Text] [Related]  

  • 2. IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites.
    Gaidamauskas E; Gyrup C; Boldt HB; Schack VR; Overgaard MT; Laursen LS; Oxvig C
    Biochim Biophys Acta; 2013 Mar; 1830(3):2701-9. PubMed ID: 23671931
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity.
    Boldt HB; Kjaer-Sorensen K; Overgaard MT; Weyer K; Poulsen CB; Sottrup-Jensen L; Conover CA; Giudice LC; Oxvig C
    J Biol Chem; 2004 Sep; 279(37):38525-31. PubMed ID: 15262980
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A.
    Laursen LS; Overgaard MT; Søe R; Boldt HB; Sottrup-Jensen L; Giudice LC; Conover CA; Oxvig C
    FEBS Lett; 2001 Aug; 504(1-2):36-40. PubMed ID: 11522292
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A.
    Gyrup C; Oxvig C
    Biochemistry; 2007 Feb; 46(7):1972-80. PubMed ID: 17249697
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module.
    Weyer K; Overgaard MT; Laursen LS; Nielsen CG; Schmitz A; Christiansen M; Sottrup-Jensen L; Giudice LC; Oxvig C
    Eur J Biochem; 2004 Apr; 271(8):1525-35. PubMed ID: 15066178
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.
    Boldt HB; Overgaard MT; Laursen LS; Weyer K; Sottrup-Jensen L; Oxvig C
    Biochem J; 2001 Sep; 358(Pt 2):359-67. PubMed ID: 11513734
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules.
    Boldt HB; Glerup S; Overgaard MT; Sottrup-Jensen L; Oxvig C
    Protein Expr Purif; 2006 Aug; 48(2):261-73. PubMed ID: 16529943
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module.
    Weyer K; Boldt HB; Poulsen CB; Kjaer-Sorensen K; Gyrup C; Oxvig C
    J Biol Chem; 2007 Apr; 282(15):10988-99. PubMed ID: 17314100
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Selection of the dominant follicle and insulin-like growth factor (IGF)-binding proteins: evidence that pregnancy-associated plasma protein A contributes to proteolysis of IGF-binding protein 5 in bovine follicular fluid.
    Rivera GM; Fortune JE
    Endocrinology; 2003 Feb; 144(2):437-46. PubMed ID: 12538602
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase.
    Overgaard MT; Boldt HB; Laursen LS; Sottrup-Jensen L; Conover CA; Oxvig C
    J Biol Chem; 2001 Jun; 276(24):21849-53. PubMed ID: 11264294
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation.
    Monget P; Mazerbourg S; Delpuech T; Maurel MC; Manière S; Zapf J; Lalmanach G; Oxvig C; Overgaard MT
    Biol Reprod; 2003 Jan; 68(1):77-86. PubMed ID: 12493698
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation.
    Giudice LC; Conover CA; Bale L; Faessen GH; Ilg K; Sun I; Imani B; Suen LF; Irwin JC; Christiansen M; Overgaard MT; Oxvig C
    J Clin Endocrinol Metab; 2002 May; 87(5):2359-66. PubMed ID: 11994388
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester.
    Sivanandam AS; Mohan S; Kita H; Kapur S; Chen ST; Linkhart TA; Bagi G; Baylink DJ; Qin X
    Biochem J; 2004 Apr; 379(Pt 1):57-64. PubMed ID: 14705967
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity.
    Søe R; Overgaard MT; Thomsen AR; Laursen LS; Olsen IM; Sottrup-Jensen L; Haaning J; Giudice LC; Conover CA; Oxvig C
    Eur J Biochem; 2002 Apr; 269(8):2247-56. PubMed ID: 11985604
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length.
    DiPrisco B; Kumar A; Kalra B; Savjani GV; Michael Z; Farr O; Papathanasiou AE; Christou H; Mantzoros C
    Metabolism; 2019 Nov; 100():153959. PubMed ID: 31401027
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease.
    Qin X; Byun D; Lau KH; Baylink DJ; Mohan S
    Arch Biochem Biophys; 2000 Jul; 379(2):209-16. PubMed ID: 10898936
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation.
    Fowlkes JL; Thrailkill KM; George-Nascimento C; Rosenberg CK; Serra DM
    Endocrinology; 1997 Jun; 138(6):2280-5. PubMed ID: 9165012
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro.
    Byun D; Mohan S; Yoo M; Sexton C; Baylink DJ; Qin X
    J Clin Endocrinol Metab; 2001 Feb; 86(2):847-54. PubMed ID: 11158056
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment.
    Overgaard MT; Sorensen ES; Stachowiak D; Boldt HB; Kristensen L; Sottrup-Jensen L; Oxvig C
    J Biol Chem; 2003 Jan; 278(4):2106-17. PubMed ID: 12421832
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.