127 related articles for article (PubMed ID: 12270161)
21. Novel allocolchicinoids with an eight membered B-ring: design, synthesis and inhibition of tubulin assembly.
Brecht R; Seitz G; Guénard D; Thoret S
Bioorg Med Chem; 2000 Mar; 8(3):557-62. PubMed ID: 10732972
[TBL] [Abstract][Full Text] [Related]
22. Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors.
Guan J; Zhu XK; Tachibana Y; Bastow KF; Brossi A; Hamel E; Lee KH
Bioorg Med Chem; 1998 Nov; 6(11):2127-31. PubMed ID: 9881102
[TBL] [Abstract][Full Text] [Related]
23. Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.
Shi Q; Verdier-Pinard P; Brossi A; Hamel E; McPhail AT; Lee KH
J Med Chem; 1997 Mar; 40(6):961-6. PubMed ID: 9083485
[TBL] [Abstract][Full Text] [Related]
24. Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (speciocolchine).
Muzaffar A; Brossi A; Hamel E
J Nat Prod; 1990; 53(4):1021-4. PubMed ID: 2095370
[TBL] [Abstract][Full Text] [Related]
25. Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.
Sun L; Hamel E; Lin CM; Hastie SB; Pyluck A; Lee KH
J Med Chem; 1993 May; 36(10):1474-9. PubMed ID: 8496915
[TBL] [Abstract][Full Text] [Related]
26. Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives.
Marzo-Mas A; Falomir E; Murga J; Carda M; Marco JA
Eur J Med Chem; 2018 Apr; 150():591-600. PubMed ID: 29550732
[TBL] [Abstract][Full Text] [Related]
27. N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties.
Kang GJ; Getahun Z; Muzaffar A; Brossi A; Hamel E
J Biol Chem; 1990 Jun; 265(18):10255-9. PubMed ID: 2191947
[TBL] [Abstract][Full Text] [Related]
28. 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
Odlo K; Hentzen J; dit Chabert JF; Ducki S; Gani OA; Sylte I; Skrede M; Flørenes VA; Hansen TV
Bioorg Med Chem; 2008 May; 16(9):4829-38. PubMed ID: 18396050
[TBL] [Abstract][Full Text] [Related]
29. Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors.
Fu DJ; Li P; Wu BW; Cui XX; Zhao CB; Zhang SY
Eur J Med Chem; 2019 Mar; 165():309-322. PubMed ID: 30690300
[TBL] [Abstract][Full Text] [Related]
30. Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies.
Burja B; Cimbora-Zovko T; Tomić S; Jelusić T; Kocevar M; Polanc S; Osmak M
Bioorg Med Chem; 2010 Apr; 18(7):2375-87. PubMed ID: 20338766
[TBL] [Abstract][Full Text] [Related]
31. Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents.
Duan YT; Man RJ; Tang DJ; Yao YF; Tao XX; Yu C; Liang XY; Makawana JA; Zou MJ; Wang ZC; Zhu HL
Sci Rep; 2016 May; 6():25387. PubMed ID: 27138035
[TBL] [Abstract][Full Text] [Related]
32. N-deacetyl-N-aminoacylthiocolchicine derivatives: synthesis and biological evaluation on MDR-positive and MDR-negative human cancer cell lines.
Gelmi ML; Mottadelli S; Pocar D; Riva A; Bombardelli E; De Vincenzo R; Scambia G
J Med Chem; 1999 Dec; 42(25):5272-6. PubMed ID: 10602712
[TBL] [Abstract][Full Text] [Related]
33. Diels-Alder reaction-aromatization approach toward functionalized ring C allocolchicinoids. Enantioselective total synthesis of (-)-7S-allocolchicine.
Vorogushin AV; Predeus AV; Wulff WD; Hansen HJ
J Org Chem; 2003 Jul; 68(15):5826-31. PubMed ID: 12868914
[TBL] [Abstract][Full Text] [Related]
34. Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability.
Wang Z; Yang D; Mohanakrishnan AK; Fanwick PE; Nampoothiri P; Hamel E; Cushman M
J Med Chem; 2000 Jun; 43(12):2419-29. PubMed ID: 10882369
[TBL] [Abstract][Full Text] [Related]
35. Roles of colchicine rings B and C in the binding process to tubulin.
Medrano FJ; Andreu JM; Gorbunoff MJ; Timasheff SN
Biochemistry; 1989 Jun; 28(13):5589-99. PubMed ID: 2775723
[TBL] [Abstract][Full Text] [Related]
36. Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Zhang SX; Bastow KF; Tachibana Y; Kuo SC; Hamel E; Mauger A; Narayanan VL; Lee KH
J Med Chem; 1999 Oct; 42(20):4081-7. PubMed ID: 10514278
[TBL] [Abstract][Full Text] [Related]
37. Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.
Liou JP; Chang JY; Chang CW; Chang CY; Mahindroo N; Kuo FM; Hsieh HP
J Med Chem; 2004 May; 47(11):2897-905. PubMed ID: 15139768
[TBL] [Abstract][Full Text] [Related]
38. Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.
Kozaka T; Nakagawa-Goto K; Shi Q; Lai CY; Hamel E; Bastow KF; Brossi A; Lee KH
Bioorg Med Chem Lett; 2010 Jul; 20(14):4091-4. PubMed ID: 20542428
[TBL] [Abstract][Full Text] [Related]
39. Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
Romagnoli R; Baraldi PG; Pavani MG; Tabrizi MA; Preti D; Fruttarolo F; Piccagli L; Jung MK; Hamel E; Borgatti M; Gambari R
J Med Chem; 2006 Jun; 49(13):3906-15. PubMed ID: 16789746
[TBL] [Abstract][Full Text] [Related]
40. Total synthesis of indole-derived allocolchicine analogues exhibiting strong apoptosis-inducing activity.
Sitnikov N; Velder J; Abodo L; Cuvelier N; Neudörfl J; Prokop A; Krause G; Fedorov AY; Schmalz HG
Chemistry; 2012 Sep; 18(38):12096-102. PubMed ID: 22927359
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
